BR112012030902A2 - preparação de gadobutrol no processo de etapa única por meio de dmf-acetal e n-metilimidazol - Google Patents

preparação de gadobutrol no processo de etapa única por meio de dmf-acetal e n-metilimidazol

Info

Publication number
BR112012030902A2
BR112012030902A2 BR112012030902A BR112012030902A BR112012030902A2 BR 112012030902 A2 BR112012030902 A2 BR 112012030902A2 BR 112012030902 A BR112012030902 A BR 112012030902A BR 112012030902 A BR112012030902 A BR 112012030902A BR 112012030902 A2 BR112012030902 A2 BR 112012030902A2
Authority
BR
Brazil
Prior art keywords
gadobutrol
methylimidazole
acetal
dmf
preparation
Prior art date
Application number
BR112012030902A
Other languages
English (en)
Inventor
Johannes Platzek
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of BR112012030902A2 publication Critical patent/BR112012030902A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F17/00—Compounds of rare earth metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BR112012030902A 2010-06-04 2011-05-31 preparação de gadobutrol no processo de etapa única por meio de dmf-acetal e n-metilimidazol BR112012030902A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010023105A DE102010023105A1 (de) 2010-06-04 2010-06-04 Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
PCT/EP2011/058988 WO2011151347A1 (de) 2010-06-04 2011-05-31 Gadobutrolherstellung im eintopfverfahren mittels dmf-acetal und n-methylimidazol

Publications (1)

Publication Number Publication Date
BR112012030902A2 true BR112012030902A2 (pt) 2015-09-22

Family

ID=44202185

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012030902A BR112012030902A2 (pt) 2010-06-04 2011-05-31 preparação de gadobutrol no processo de etapa única por meio de dmf-acetal e n-metilimidazol

Country Status (13)

Country Link
US (1) US20130116429A1 (pt)
EP (1) EP2576521A1 (pt)
JP (1) JP2013527212A (pt)
KR (1) KR20130089229A (pt)
CN (1) CN102933562A (pt)
AU (1) AU2011260310A1 (pt)
BR (1) BR112012030902A2 (pt)
CA (1) CA2801255A1 (pt)
DE (1) DE102010023105A1 (pt)
MX (1) MX2012014161A (pt)
RU (1) RU2012157538A (pt)
WO (1) WO2011151347A1 (pt)
ZA (1) ZA201209037B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS60001B1 (sr) 2011-04-21 2020-04-30 Bayer Ip Gmbh Pripremanje gadobutrola visoke čistoće
KR101653064B1 (ko) 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
CN109293592A (zh) * 2017-07-24 2019-02-01 天津科伦药物研究有限公司 一种制备钆布醇的方法
CN109384737A (zh) * 2017-08-04 2019-02-26 天津科伦药物研究有限公司 一种四氮杂环钇络合物及其制备方法和应用
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR20190088793A (ko) * 2018-01-19 2019-07-29 주식회사 엔지켐생명과학 칼코부트롤의 제조방법
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
CN113105407A (zh) * 2020-01-13 2021-07-13 北京北陆药业股份有限公司 一种钆布醇新型晶型及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369099A (en) * 1981-01-08 1983-01-18 Bell Telephone Laboratories, Incorporated Photoelectrochemical etching of semiconductors
DE4009119A1 (de) 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4237943C2 (de) 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE19608307C1 (de) 1996-02-26 1997-08-28 Schering Ag Verfahren zur Herstellung von 1,4,7,10-Tetraazacyclododecan und dessen Derivaten
DE19724186C2 (de) 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe

Also Published As

Publication number Publication date
EP2576521A1 (de) 2013-04-10
US20130116429A1 (en) 2013-05-09
MX2012014161A (es) 2013-02-27
JP2013527212A (ja) 2013-06-27
CA2801255A1 (en) 2011-12-08
CN102933562A (zh) 2013-02-13
DE102010023105A1 (de) 2011-12-08
AU2011260310A1 (en) 2013-01-10
RU2012157538A (ru) 2014-07-20
KR20130089229A (ko) 2013-08-09
ZA201209037B (en) 2014-02-26
WO2011151347A1 (de) 2011-12-08

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.