BR112012030689A2 - cristal de derivado de tienopirimidina - Google Patents
cristal de derivado de tienopirimidinaInfo
- Publication number
- BR112012030689A2 BR112012030689A2 BR112012030689A BR112012030689A BR112012030689A2 BR 112012030689 A2 BR112012030689 A2 BR 112012030689A2 BR 112012030689 A BR112012030689 A BR 112012030689A BR 112012030689 A BR112012030689 A BR 112012030689A BR 112012030689 A2 BR112012030689 A2 BR 112012030689A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivative crystal
- thienopyrimidine derivative
- crystals
- thienopyrimidine
- heating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
cristal de derivado de tienopirimidina. cristais são obtidos através de aquecimento de uma suspensão aquosa de ácido 2-(3,4-diclorobenzil)-5-metil-4-oxo-3,4-di-hidrotieno[2,3-d]pirimidino-6-carboxílico.novos cristais são obtidos através do ajuste da temperatura e/ou duração de aquecimento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010-125362 | 2010-05-31 | ||
JP2010125362 | 2010-05-31 | ||
PCT/JP2011/062513 WO2011152411A1 (ja) | 2010-05-31 | 2011-05-31 | チエノピリミジン誘導体の結晶 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012030689A2 true BR112012030689A2 (pt) | 2016-09-13 |
BR112012030689B1 BR112012030689B1 (pt) | 2021-11-09 |
Family
ID=45066774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012030689-8A BR112012030689B1 (pt) | 2010-05-31 | 2011-05-31 | Cristal de derivado de tienopirimidina, medicamento, composição farmacêutica e método de produção e uso do cristal |
Country Status (15)
Country | Link |
---|---|
US (2) | US8748437B2 (pt) |
EP (1) | EP2594570B1 (pt) |
JP (1) | JP5744017B2 (pt) |
KR (1) | KR101721288B1 (pt) |
CN (1) | CN103038238B (pt) |
AU (1) | AU2011260861B2 (pt) |
BR (1) | BR112012030689B1 (pt) |
CA (1) | CA2801030C (pt) |
EA (1) | EA021987B1 (pt) |
ES (1) | ES2532110T3 (pt) |
IL (1) | IL223267A (pt) |
MX (1) | MX2012013924A (pt) |
UA (1) | UA111589C2 (pt) |
WO (1) | WO2011152411A1 (pt) |
ZA (1) | ZA201209488B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8748437B2 (en) * | 2010-05-31 | 2014-06-10 | Aska Pharmaceutical Co., Ltd. | Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid |
WO2018009899A1 (en) | 2016-07-07 | 2018-01-11 | Cardurion Pharmaceuticals, Llc | Methods for treatment of heart failure |
SG11202010161UA (en) * | 2018-04-17 | 2020-11-27 | Cardurion Pharmaceuticals Llc | Meglumine salts of thienopyrimidines |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4488867B2 (ja) | 2004-11-05 | 2010-06-23 | 株式会社東芝 | パターン形成方法 |
AU2006258461B2 (en) * | 2005-06-14 | 2011-08-25 | Aska Pharmaceutical Co., Ltd. | Thienopyrimidine derivative |
JPWO2008072778A1 (ja) | 2006-12-13 | 2010-04-02 | あすか製薬株式会社 | 尿路系疾患の処置剤 |
JP5047136B2 (ja) | 2008-11-26 | 2012-10-10 | サンデン株式会社 | 飲料用容器分別機 |
US8748437B2 (en) * | 2010-05-31 | 2014-06-10 | Aska Pharmaceutical Co., Ltd. | Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid |
-
2011
- 2011-05-31 US US13/700,935 patent/US8748437B2/en active Active
- 2011-05-31 MX MX2012013924A patent/MX2012013924A/es active IP Right Grant
- 2011-05-31 JP JP2012518407A patent/JP5744017B2/ja active Active
- 2011-05-31 KR KR1020127034316A patent/KR101721288B1/ko active IP Right Grant
- 2011-05-31 CA CA2801030A patent/CA2801030C/en active Active
- 2011-05-31 WO PCT/JP2011/062513 patent/WO2011152411A1/ja active Application Filing
- 2011-05-31 EA EA201291289A patent/EA021987B1/ru not_active IP Right Cessation
- 2011-05-31 CN CN201180037709.3A patent/CN103038238B/zh active Active
- 2011-05-31 AU AU2011260861A patent/AU2011260861B2/en active Active
- 2011-05-31 EP EP11789814.8A patent/EP2594570B1/en active Active
- 2011-05-31 ES ES11789814.8T patent/ES2532110T3/es active Active
- 2011-05-31 BR BR112012030689-8A patent/BR112012030689B1/pt active IP Right Grant
- 2011-05-31 UA UAA201214994A patent/UA111589C2/uk unknown
-
2012
- 2012-11-26 IL IL223267A patent/IL223267A/en active IP Right Grant
- 2012-12-13 ZA ZA2012/09488A patent/ZA201209488B/en unknown
-
2014
- 2014-03-26 US US14/226,505 patent/US9006253B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN103038238B (zh) | 2016-05-04 |
KR20130112734A (ko) | 2013-10-14 |
BR112012030689B1 (pt) | 2021-11-09 |
IL223267A0 (en) | 2013-02-03 |
JP5744017B2 (ja) | 2015-07-01 |
US20140235655A1 (en) | 2014-08-21 |
WO2011152411A1 (ja) | 2011-12-08 |
EP2594570B1 (en) | 2015-02-25 |
JPWO2011152411A1 (ja) | 2013-08-01 |
UA111589C2 (uk) | 2016-05-25 |
EP2594570A1 (en) | 2013-05-22 |
ZA201209488B (en) | 2014-02-26 |
US20130123279A1 (en) | 2013-05-16 |
MX2012013924A (es) | 2013-05-01 |
CA2801030A1 (en) | 2011-12-08 |
ES2532110T3 (es) | 2015-03-24 |
AU2011260861A1 (en) | 2013-01-10 |
CA2801030C (en) | 2018-11-27 |
KR101721288B1 (ko) | 2017-03-29 |
IL223267A (en) | 2016-10-31 |
EA201291289A1 (ru) | 2013-05-30 |
CN103038238A (zh) | 2013-04-10 |
US9006253B2 (en) | 2015-04-14 |
EP2594570A4 (en) | 2013-11-27 |
US8748437B2 (en) | 2014-06-10 |
EA021987B1 (ru) | 2015-10-30 |
AU2011260861B2 (en) | 2014-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/05/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |