BR112012029248B1 - Análogo de glp-1 de fórmula i ou a sua composição, análogo de glp-1 de fórmula viii ou um sal farmaceuticamente aceitável ou a composição do mesmo, composição farmacêutica e uso de um composto - Google Patents
Análogo de glp-1 de fórmula i ou a sua composição, análogo de glp-1 de fórmula viii ou um sal farmaceuticamente aceitável ou a composição do mesmo, composição farmacêutica e uso de um composto Download PDFInfo
- Publication number
- BR112012029248B1 BR112012029248B1 BR112012029248-0A BR112012029248A BR112012029248B1 BR 112012029248 B1 BR112012029248 B1 BR 112012029248B1 BR 112012029248 A BR112012029248 A BR 112012029248A BR 112012029248 B1 BR112012029248 B1 BR 112012029248B1
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- Prior art keywords
- glp
- acid
- histidine
- hydrogen
- analog
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- 230000000930 thermomechanical effect Effects 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- GHCZAUBVMUEKKP-UHFFFAOYSA-N ursodeoxycholic acid glycine-conjugate Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)CC2 GHCZAUBVMUEKKP-UHFFFAOYSA-N 0.000 description 1
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- 238000003828 vacuum filtration Methods 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
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- 239000003643 water by type Substances 0.000 description 1
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- 235000010447 xylitol Nutrition 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2010/000692 WO2011143788A1 (en) | 2010-05-17 | 2010-05-17 | Novel glucagon like peptide analogs, composition, and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012029248A2 BR112012029248A2 (pt) | 2020-06-02 |
| BR112012029248B1 true BR112012029248B1 (pt) | 2021-09-28 |
Family
ID=44991143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012029248-0A BR112012029248B1 (pt) | 2010-05-17 | 2010-05-17 | Análogo de glp-1 de fórmula i ou a sua composição, análogo de glp-1 de fórmula viii ou um sal farmaceuticamente aceitável ou a composição do mesmo, composição farmacêutica e uso de um composto |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9487570B2 (enExample) |
| EP (1) | EP2571897B1 (enExample) |
| JP (1) | JP5819946B2 (enExample) |
| KR (1) | KR101609302B1 (enExample) |
| CN (1) | CN103124739B (enExample) |
| AU (1) | AU2010353685B2 (enExample) |
| BR (1) | BR112012029248B1 (enExample) |
| CA (1) | CA2802931C (enExample) |
| ES (1) | ES2528496T3 (enExample) |
| RU (1) | RU2557301C2 (enExample) |
| SG (1) | SG185604A1 (enExample) |
| WO (1) | WO2011143788A1 (enExample) |
| ZA (1) | ZA201209566B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2531590C2 (ru) * | 2010-04-27 | 2014-10-20 | Бета Фармасьютикалс,Ко,Лтд. | Аналоги глюкагоноподобного пептида-1 и их применение |
| CA2861541C (en) * | 2012-01-24 | 2021-11-30 | University Of Massachusetts | Soluble manf in pancreatic beta-cell disorders |
| WO2019082138A1 (en) * | 2017-10-27 | 2019-05-02 | Lorven Biologics Private Limited | PROCESS FOR THE PREPARATION OF LIRAGLUTIDE USING RECOMBINANT SACCHAROMYCES CEREVISIAE |
| WO2020118843A1 (zh) * | 2018-12-12 | 2020-06-18 | 四川利通科创生物医药科技有限公司 | 一种glp-1突变体及其制备方法和用途 |
| CN110845601B (zh) * | 2019-10-12 | 2021-01-19 | 广东药科大学 | 不同构型的glp-1类似肽修饰二聚体及其制备方法在治疗ii型糖尿病中的应用 |
| CN110862448A (zh) * | 2019-11-21 | 2020-03-06 | 浙江大学 | 两性离子多肽修饰的glp-1衍生物及其制备方法和应用 |
| CN111253475B (zh) * | 2020-02-18 | 2021-03-09 | 江苏诺泰澳赛诺生物制药股份有限公司 | Glp-1激动多肽化合物及其盐与合成方法及用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| DE69129226T2 (de) | 1990-01-24 | 1998-07-30 | Douglas I. Woodside Calif. Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| AU6479101A (en) * | 2000-06-16 | 2002-01-02 | Lilly Co Eli | Glucagon-like peptide-1 analogs |
| HUP0700151A2 (en) * | 2001-10-18 | 2007-05-29 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| WO2003033672A2 (en) * | 2001-10-19 | 2003-04-24 | Riken | Nr3b nmda receptor subunit compositions and related methods |
| JP2005535569A (ja) * | 2002-04-04 | 2005-11-24 | ノボ・ノルデイスク・エー／エス | Ｇｌｐ−１アゴニスト及び心臓血管合併症 |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EA009366B1 (ru) * | 2003-03-19 | 2007-12-28 | Эли Лилли Энд Компани | Связанные с полиэтиленгликолем соединения гпп-1 |
| BRPI0410972C1 (pt) * | 2003-06-03 | 2021-05-25 | Novo Nordisk As | método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia |
| BRPI0506694A (pt) * | 2004-01-08 | 2007-05-02 | Theratechnologies Inc | análogos de peptìdeo-1 semelhante ao glucagon com longa duração de ação |
| CN100503637C (zh) * | 2004-04-14 | 2009-06-24 | 浙江贝达药业有限公司 | 胰高血糖素样肽类似物、其组合物及其使用方法 |
| CN100535006C (zh) * | 2004-09-06 | 2009-09-02 | 上海华谊生物技术有限公司 | Glp-1类似物 |
| BRPI0519393A2 (pt) * | 2004-12-22 | 2009-01-20 | Lilly Co Eli | formulaÇço em soluÇço estÁvel |
| TWI372629B (en) * | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| KR101011081B1 (ko) * | 2005-05-13 | 2011-01-25 | 일라이 릴리 앤드 캄파니 | Ｐｅｇ화된 ｇｌｐ-1 화합물 |
| EP1940438A4 (en) * | 2005-09-08 | 2009-10-21 | Tufts College | STABILIZED GLP-1 ANALOGUES |
| DE102005063375A1 (de) * | 2005-09-15 | 2007-04-19 | Schülke & Mayr GmbH | Antimikrobielle Zubereitungen mit einem Gehalt an Octenidindihydrochlorid verkapselt in Liposomen |
| MX2008013304A (es) * | 2006-04-20 | 2008-10-27 | Amgen Inc | Compuestos de peptido 1 tipo glucagon. |
| WO2008082656A1 (en) * | 2006-12-29 | 2008-07-10 | Ipsen Pharma S.A.S. | Glp-1 pharmaceutical compositions |
| GB0717399D0 (en) * | 2007-09-07 | 2007-10-17 | Uutech Ltd | Use of GLP-1 analogues for the treatment of disorders associated with dysfunctional synaptic transmission |
| ES2369731T3 (es) * | 2007-09-07 | 2011-12-05 | Janssen Pharmaceutica Nv | Combinaciones de pirimetanil y compuestos de plata. |
| US20100317057A1 (en) * | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
-
2010
- 2010-05-17 WO PCT/CN2010/000692 patent/WO2011143788A1/en not_active Ceased
- 2010-05-17 CN CN201080066828.7A patent/CN103124739B/zh active Active
- 2010-05-17 JP JP2013510465A patent/JP5819946B2/ja not_active Expired - Fee Related
- 2010-05-17 EP EP10851547.9A patent/EP2571897B1/en not_active Not-in-force
- 2010-05-17 RU RU2012154322/10A patent/RU2557301C2/ru active
- 2010-05-17 US US13/698,819 patent/US9487570B2/en not_active Expired - Fee Related
- 2010-05-17 SG SG2012084323A patent/SG185604A1/en unknown
- 2010-05-17 CA CA2802931A patent/CA2802931C/en active Active
- 2010-05-17 BR BR112012029248-0A patent/BR112012029248B1/pt not_active IP Right Cessation
- 2010-05-17 ES ES10851547.9T patent/ES2528496T3/es active Active
- 2010-05-17 KR KR1020127033002A patent/KR101609302B1/ko not_active Expired - Fee Related
- 2010-05-17 AU AU2010353685A patent/AU2010353685B2/en not_active Ceased
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2012
- 2012-12-14 ZA ZA2012/09566A patent/ZA201209566B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012029248A2 (pt) | 2020-06-02 |
| AU2010353685A1 (en) | 2013-01-10 |
| US20130203672A1 (en) | 2013-08-08 |
| JP2013527178A (ja) | 2013-06-27 |
| EP2571897B1 (en) | 2014-11-05 |
| JP5819946B2 (ja) | 2015-11-24 |
| WO2011143788A1 (en) | 2011-11-24 |
| ES2528496T3 (es) | 2015-02-10 |
| AU2010353685B2 (en) | 2014-09-25 |
| RU2557301C2 (ru) | 2015-07-20 |
| CA2802931C (en) | 2016-10-04 |
| CN103124739A (zh) | 2013-05-29 |
| EP2571897A4 (en) | 2013-11-06 |
| AU2010353685A8 (en) | 2013-05-09 |
| US9487570B2 (en) | 2016-11-08 |
| CN103124739B (zh) | 2015-11-25 |
| EP2571897A1 (en) | 2013-03-27 |
| CA2802931A1 (en) | 2011-11-24 |
| KR101609302B1 (ko) | 2016-04-06 |
| RU2012154322A (ru) | 2014-06-27 |
| ZA201209566B (en) | 2013-08-28 |
| KR20130039740A (ko) | 2013-04-22 |
| SG185604A1 (en) | 2012-12-28 |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: SHAOJING HU (CN) ; BETTA PHARMACEUTICALS CO., LTD (CN) |
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| B25A | Requested transfer of rights approved |
Owner name: BETTA PHARMACEUTICALS CO., LTD (CN) |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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