BR112012006842A2 - derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina flúor substituídos e seus métodos de uso - Google Patents
derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina flúor substituídos e seus métodos de usoInfo
- Publication number
- BR112012006842A2 BR112012006842A2 BR112012006842A BR112012006842A BR112012006842A2 BR 112012006842 A2 BR112012006842 A2 BR 112012006842A2 BR 112012006842 A BR112012006842 A BR 112012006842A BR 112012006842 A BR112012006842 A BR 112012006842A BR 112012006842 A2 BR112012006842 A2 BR 112012006842A2
- Authority
- BR
- Brazil
- Prior art keywords
- indazol
- dicyano
- dimethyl
- methods
- dihydropyridine derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 fluorine 3,5-dicyano-4- (1h-indazol-5-yl) -2,6-dimethyl-1,4-dihydropyridine derivatives Chemical class 0.000 title 1
- BZMMZEUTUBQCMP-UHFFFAOYSA-N 4-(1h-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile Chemical class N#CC1=C(C)NC(C)=C(C#N)C1C1=CC=C(NN=C2)C2=C1 BZMMZEUTUBQCMP-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172304 | 2009-10-06 | ||
| PCT/EP2010/064648 WO2011042368A1 (en) | 2009-10-06 | 2010-10-01 | Fluoro-substituted 3,5-dicyano-4-(1h-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012006842A2 true BR112012006842A2 (pt) | 2016-06-07 |
Family
ID=43357944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012006842A BR112012006842A2 (pt) | 2009-10-06 | 2010-10-01 | derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina flúor substituídos e seus métodos de uso |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9422263B2 (https=) |
| EP (1) | EP2485726B1 (https=) |
| JP (1) | JP5753175B2 (https=) |
| KR (1) | KR20120091005A (https=) |
| CN (1) | CN102573838B (https=) |
| AR (1) | AR078486A1 (https=) |
| AU (1) | AU2010305550A1 (https=) |
| BR (1) | BR112012006842A2 (https=) |
| CA (1) | CA2773676C (https=) |
| CL (1) | CL2012000753A1 (https=) |
| CR (1) | CR20120150A (https=) |
| CU (1) | CU20120051A7 (https=) |
| DO (1) | DOP2012000085A (https=) |
| EC (1) | ECSP12011748A (https=) |
| ES (1) | ES2458117T3 (https=) |
| IL (1) | IL218415A0 (https=) |
| IN (1) | IN2012DN02675A (https=) |
| MX (1) | MX2012003603A (https=) |
| NZ (1) | NZ599006A (https=) |
| PE (1) | PE20121392A1 (https=) |
| PH (1) | PH12012500640A1 (https=) |
| RU (1) | RU2012111695A (https=) |
| SG (1) | SG178990A1 (https=) |
| TW (1) | TW201124396A (https=) |
| UY (1) | UY32922A (https=) |
| WO (1) | WO2011042368A1 (https=) |
| ZA (1) | ZA201201524B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0650179Y2 (ja) | 1989-06-01 | 1994-12-21 | 株式会社プラコー | ブロー成形機用のダイヘッド |
| JPH0756186Y2 (ja) | 1989-07-24 | 1995-12-25 | 株式会社日本製鋼所 | パリソンの押出成形装置 |
| JP2781376B2 (ja) | 1996-06-17 | 1998-07-30 | エクセル株式会社 | 中空成形品 |
| DE102009056886A1 (de) * | 2009-12-03 | 2011-06-09 | Bayer Schering Pharma Aktiengesellschaft | cMet-Inhibitoren zur Behandlung der Endometriose |
| SG11202108636SA (en) | 2019-02-11 | 2021-09-29 | Merck Patent Gmbh | Indazolyl-isoxazole derivatives for the treatment of diseases such as cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635977A (en) | 1969-11-03 | 1972-01-18 | American Cyanamid Co | Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil |
| DE59009485D1 (de) | 1989-01-26 | 1995-09-14 | Bayer Ag | Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung. |
| DE19546136A1 (de) | 1995-12-11 | 1997-06-12 | Bayer Ag | Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren |
| US7429609B2 (en) | 2002-05-31 | 2008-09-30 | Eisai R & D Management Co., Ltd. | Pyrazole compound and medicinal composition containing the same |
| JP2007526324A (ja) | 2004-03-02 | 2007-09-13 | スミスクライン・ビーチャム・コーポレイション | Ａｋｔ活性のある阻害剤 |
| EP1722792A1 (de) | 2004-03-03 | 2006-11-22 | Boehringer Ingelheim International GmbH | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| KR20070087602A (ko) | 2004-12-13 | 2007-08-28 | 아이알엠 엘엘씨 | 화합물 및 스테로이드성 수용체 및 칼슘 채널 활성의조절제로서의 조성물 |
| EP1858325A4 (en) | 2005-01-07 | 2010-06-30 | Roskamp Res Llc | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS FOR IDENTIFYING THESE COMPOUNDS |
| US7632839B2 (en) * | 2005-01-19 | 2009-12-15 | Merck & Co. Inc. | Mitotic kinesin inhibitors |
| EA200900779A1 (ru) * | 2006-12-14 | 2010-02-26 | Байер Шеринг Фарма Акциенгезельшафт | Производные дигидропиридина, полезные как ингибиторы протеинкиназы |
-
2010
- 2010-09-30 UY UY0001032922A patent/UY32922A/es not_active Application Discontinuation
- 2010-10-01 RU RU2012111695/04A patent/RU2012111695A/ru not_active Application Discontinuation
- 2010-10-01 ES ES10760348.2T patent/ES2458117T3/es active Active
- 2010-10-01 KR KR1020127007824A patent/KR20120091005A/ko not_active Withdrawn
- 2010-10-01 CN CN201080043306.5A patent/CN102573838B/zh not_active Expired - Fee Related
- 2010-10-01 JP JP2012532550A patent/JP5753175B2/ja not_active Expired - Fee Related
- 2010-10-01 IN IN2675DEN2012 patent/IN2012DN02675A/en unknown
- 2010-10-01 CA CA2773676A patent/CA2773676C/en not_active Expired - Fee Related
- 2010-10-01 PE PE2012000384A patent/PE20121392A1/es not_active Application Discontinuation
- 2010-10-01 AU AU2010305550A patent/AU2010305550A1/en not_active Abandoned
- 2010-10-01 BR BR112012006842A patent/BR112012006842A2/pt not_active Application Discontinuation
- 2010-10-01 US US13/496,722 patent/US9422263B2/en not_active Expired - Fee Related
- 2010-10-01 AR ARP100103574A patent/AR078486A1/es unknown
- 2010-10-01 NZ NZ599006A patent/NZ599006A/xx not_active IP Right Cessation
- 2010-10-01 SG SG2012015400A patent/SG178990A1/en unknown
- 2010-10-01 PH PH1/2012/500640A patent/PH12012500640A1/en unknown
- 2010-10-01 WO PCT/EP2010/064648 patent/WO2011042368A1/en not_active Ceased
- 2010-10-01 EP EP10760348.2A patent/EP2485726B1/en not_active Not-in-force
- 2010-10-01 MX MX2012003603A patent/MX2012003603A/es not_active Application Discontinuation
- 2010-10-05 TW TW099133784A patent/TW201124396A/zh unknown
-
2012
- 2012-02-29 ZA ZA2012/01524A patent/ZA201201524B/en unknown
- 2012-03-01 IL IL218415A patent/IL218415A0/en unknown
- 2012-03-26 CU CU20120051A patent/CU20120051A7/es unknown
- 2012-03-26 CL CL2012000753A patent/CL2012000753A1/es unknown
- 2012-03-27 DO DO2012000085A patent/DOP2012000085A/es unknown
- 2012-03-27 CR CR20120150A patent/CR20120150A/es unknown
- 2012-03-27 EC ECSP12011748 patent/ECSP12011748A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120264785A1 (en) | 2012-10-18 |
| AU2010305550A1 (en) | 2012-03-29 |
| EP2485726A1 (en) | 2012-08-15 |
| PH12012500640A1 (en) | 2012-11-12 |
| IL218415A0 (en) | 2012-04-30 |
| MX2012003603A (es) | 2012-04-20 |
| CN102573838B (zh) | 2014-09-24 |
| PE20121392A1 (es) | 2012-10-14 |
| EP2485726B1 (en) | 2014-03-12 |
| CU20120051A7 (es) | 2012-06-29 |
| KR20120091005A (ko) | 2012-08-17 |
| HK1172835A1 (en) | 2013-05-03 |
| ECSP12011748A (es) | 2012-05-30 |
| SG178990A1 (en) | 2012-04-27 |
| JP5753175B2 (ja) | 2015-07-22 |
| RU2012111695A (ru) | 2013-10-10 |
| UY32922A (es) | 2011-04-29 |
| CA2773676C (en) | 2017-07-04 |
| DOP2012000085A (es) | 2012-07-15 |
| TW201124396A (en) | 2011-07-16 |
| ES2458117T3 (es) | 2014-04-30 |
| CL2012000753A1 (es) | 2012-09-14 |
| WO2011042368A1 (en) | 2011-04-14 |
| IN2012DN02675A (https=) | 2015-09-04 |
| CA2773676A1 (en) | 2011-04-14 |
| CN102573838A (zh) | 2012-07-11 |
| ZA201201524B (en) | 2013-05-29 |
| AR078486A1 (es) | 2011-11-09 |
| CR20120150A (es) | 2012-08-03 |
| US9422263B2 (en) | 2016-08-23 |
| NZ599006A (en) | 2013-11-29 |
| JP2013506699A (ja) | 2013-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |