BR112012002677A2 - Moléculas de heteroaril-n-aril carbamatos, e composição pesticida - Google Patents
Moléculas de heteroaril-n-aril carbamatos, e composição pesticida Download PDFInfo
- Publication number
- BR112012002677A2 BR112012002677A2 BR112012002677-1A BR112012002677A BR112012002677A2 BR 112012002677 A2 BR112012002677 A2 BR 112012002677A2 BR 112012002677 A BR112012002677 A BR 112012002677A BR 112012002677 A2 BR112012002677 A2 BR 112012002677A2
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- BR
- Brazil
- Prior art keywords
- alkyl
- haloalkyl
- phenyl
- molecule
- solution
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 7
- 239000000575 pesticide Substances 0.000 title description 9
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 230000000895 acaricidal effect Effects 0.000 claims abstract 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 125000005347 halocycloalkyl group Chemical group 0.000 claims 1
- 230000002363 herbicidal effect Effects 0.000 claims 1
- 230000000749 insecticidal effect Effects 0.000 claims 1
- 230000001069 nematicidal effect Effects 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 7
- 241000607479 Yersinia pestis Species 0.000 abstract description 5
- 241000238631 Hexapoda Species 0.000 abstract description 3
- 230000000361 pesticidal effect Effects 0.000 abstract 2
- 239000000642 acaricide Substances 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000007787 solid Substances 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 8
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 238000005160 1H NMR spectroscopy Methods 0.000 description 4
- -1 4-pentafluoroethylsulfanylphenyl Chemical group 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 4
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- KCPBLTLBYXRDIG-UHFFFAOYSA-N 4-(1h-1,2,4-triazol-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1=NNC=N1 KCPBLTLBYXRDIG-UHFFFAOYSA-N 0.000 description 2
- JYJYCCSREXLSRM-UHFFFAOYSA-N 4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]benzaldehyde Chemical compound C1=CC(OC(F)(F)C(F)(F)F)=CC=C1N1N=C(C=2C=CC(C=O)=CC=2)N=C1 JYJYCCSREXLSRM-UHFFFAOYSA-N 0.000 description 2
- FFLVNBBFOPBMBS-UHFFFAOYSA-N 4-[1-[4-(1,1,2,2,2-pentafluoroethylsulfanyl)phenyl]-1,2,4-triazol-3-yl]benzonitrile Chemical compound C1=CC(SC(F)(F)C(F)(F)F)=CC=C1N1N=C(C=2C=CC(=CC=2)C#N)N=C1 FFLVNBBFOPBMBS-UHFFFAOYSA-N 0.000 description 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000256602 Isoptera Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 150000001540 azides Chemical class 0.000 description 2
- 229910000024 caesium carbonate Inorganic materials 0.000 description 2
- XMPZTFVPEKAKFH-UHFFFAOYSA-P ceric ammonium nitrate Chemical compound [NH4+].[NH4+].[Ce+4].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O XMPZTFVPEKAKFH-UHFFFAOYSA-P 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 150000007857 hydrazones Chemical class 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 229960003540 oxyquinoline Drugs 0.000 description 2
- UXPOJVLZTPGWFX-UHFFFAOYSA-N pentafluoroethyl iodide Chemical compound FC(F)(F)C(F)(F)I UXPOJVLZTPGWFX-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 2
- 150000003852 triazoles Chemical class 0.000 description 2
- ABFQGKLGHIQREF-UHFFFAOYSA-N (4-butylphenyl)hydrazine Chemical compound CCCCC1=CC=C(NN)C=C1 ABFQGKLGHIQREF-UHFFFAOYSA-N 0.000 description 1
- XYKZEZPREAUXDQ-UHFFFAOYSA-N 1,1,2,2,2-pentafluoroethylbenzene Chemical compound FC(F)(F)C(F)(F)C1=CC=CC=C1 XYKZEZPREAUXDQ-UHFFFAOYSA-N 0.000 description 1
- BQDSGIJLCHMRMT-UHFFFAOYSA-N 1,3-diphenyl-2h-triazole Chemical compound N1N(C=2C=CC=CC=2)C=CN1C1=CC=CC=C1 BQDSGIJLCHMRMT-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- BGNSROFPLXZBJD-UHFFFAOYSA-N 1-bromo-4-(1,1,2,2,2-pentafluoroethoxy)benzene Chemical compound FC(F)(F)C(F)(F)OC1=CC=C(Br)C=C1 BGNSROFPLXZBJD-UHFFFAOYSA-N 0.000 description 1
- PVBVOTISXJPMFC-UHFFFAOYSA-N 1-bromo-4-(1,1,2,2,2-pentafluoroethyl)benzene Chemical compound FC(F)(F)C(F)(F)C1=CC=C(Br)C=C1 PVBVOTISXJPMFC-UHFFFAOYSA-N 0.000 description 1
- LZYKKNNAZGJMGW-UHFFFAOYSA-N 1-bromo-4-(1,1,2,2,2-pentafluoroethylsulfanyl)benzene Chemical compound FC(F)(F)C(F)(F)SC1=CC=C(Br)C=C1 LZYKKNNAZGJMGW-UHFFFAOYSA-N 0.000 description 1
- UCCUXODGPMAHRL-UHFFFAOYSA-N 1-bromo-4-iodobenzene Chemical compound BrC1=CC=C(I)C=C1 UCCUXODGPMAHRL-UHFFFAOYSA-N 0.000 description 1
- RTUDBROGOZBBIC-UHFFFAOYSA-N 1-iodo-4-(trifluoromethoxy)benzene Chemical compound FC(F)(F)OC1=CC=C(I)C=C1 RTUDBROGOZBBIC-UHFFFAOYSA-N 0.000 description 1
- FQXWOBTWXNNOBR-UHFFFAOYSA-N 3-(4-methylphenyl)-1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1C1=NN(C=2C=CC(OC(F)(F)C(F)(F)F)=CC=2)C=N1 FQXWOBTWXNNOBR-UHFFFAOYSA-N 0.000 description 1
- YRLPTXZGVYPJIF-UHFFFAOYSA-N 3-(4-methylphenyl)-1-[4-(1,1,2,2,2-pentafluoroethyl)phenyl]-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1C1=NN(C=2C=CC(=CC=2)C(F)(F)C(F)(F)F)C=N1 YRLPTXZGVYPJIF-UHFFFAOYSA-N 0.000 description 1
- CNGBDMZNBSGAQD-UHFFFAOYSA-N 4-[1-[4-(1,1,2,2,2-pentafluoroethyl)phenyl]-1,2,4-triazol-3-yl]benzaldehyde Chemical compound C1=CC(C(F)(F)C(F)(F)F)=CC=C1N1N=C(C=2C=CC(C=O)=CC=2)N=C1 CNGBDMZNBSGAQD-UHFFFAOYSA-N 0.000 description 1
- FTBCOQFMQSTCQQ-UHFFFAOYSA-N 4-bromobenzenethiol Chemical compound SC1=CC=C(Br)C=C1 FTBCOQFMQSTCQQ-UHFFFAOYSA-N 0.000 description 1
- WZWIQYMTQZCSKI-UHFFFAOYSA-N 4-cyanobenzaldehyde Chemical compound O=CC1=CC=C(C#N)C=C1 WZWIQYMTQZCSKI-UHFFFAOYSA-N 0.000 description 1
- 125000004863 4-trifluoromethoxyphenyl group Chemical group [H]C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1* 0.000 description 1
- ZASQHVAGPKBSHH-UHFFFAOYSA-N 5-(4-methylphenyl)-1h-1,2,4-triazole Chemical compound C1=CC(C)=CC=C1C1=NNC=N1 ZASQHVAGPKBSHH-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- HTZCNXWZYVXIMZ-UHFFFAOYSA-M benzyl(triethyl)azanium;chloride Chemical compound [Cl-].CC[N+](CC)(CC)CC1=CC=CC=C1 HTZCNXWZYVXIMZ-UHFFFAOYSA-M 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000013058 crude material Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- ZUTQMSKSJGJJJU-UHFFFAOYSA-N n-diazonio-4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1,2,4-triazol-3-yl]benzenecarboximidate Chemical compound C1=CC(OC(F)(F)C(F)(F)F)=CC=C1N1N=C(C=2C=CC(=CC=2)C(=O)N=[N+]=[N-])N=C1 ZUTQMSKSJGJJJU-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- XUXNAKZDHHEHPC-UHFFFAOYSA-M sodium bromate Chemical compound [Na+].[O-]Br(=O)=O XUXNAKZDHHEHPC-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/20—N-Aryl derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
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|---|---|---|---|
| US23214209P | 2009-08-07 | 2009-08-07 | |
| PCT/US2010/044538 WO2011017513A1 (en) | 2009-08-07 | 2010-08-05 | Pesticidal compositions |
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| BR112012002677A2 true BR112012002677A2 (pt) | 2021-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| BR112012002677-1A BR112012002677A2 (pt) | 2009-08-07 | 2010-08-05 | Moléculas de heteroaril-n-aril carbamatos, e composição pesticida |
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| AR (1) | AR077817A1 (https=) |
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| BR (1) | BR112012002677A2 (https=) |
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| CL (1) | CL2012000315A1 (https=) |
| CO (1) | CO6491072A2 (https=) |
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| MX (1) | MX2012001621A (https=) |
| NZ (1) | NZ597597A (https=) |
| PL (1) | PL2461688T3 (https=) |
| RU (1) | RU2532470C2 (https=) |
| UA (1) | UA108208C2 (https=) |
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| ZA (1) | ZA201200817B (https=) |
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| NZ587143A (en) | 2008-02-12 | 2011-07-29 | Dow Agrosciences Llc | Pesticidal compositions |
| ES2921576T3 (es) | 2008-12-19 | 2022-08-29 | Vertex Pharma | Compuestos útiles como inhibidores de la quinasa ATR |
| KR101798248B1 (ko) | 2009-08-07 | 2017-11-15 | 다우 아그로사이언시즈 엘엘씨 | 살충 조성물 |
| US9334244B2 (en) | 2010-05-12 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| NZ603477A (en) | 2010-05-12 | 2014-09-26 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
| JP4957859B2 (ja) * | 2010-08-31 | 2012-06-20 | Jfeスチール株式会社 | 種子被覆用鉄粉及び種子 |
| JP5071577B2 (ja) * | 2010-11-12 | 2012-11-14 | Jfeスチール株式会社 | 種子被覆剤及び該種子被覆剤で被覆した種子 |
| AR087119A1 (es) | 2011-07-12 | 2014-02-12 | Dow Agrosciences Llc | Composiciones plaguicidas y procesos relacionados |
| CN106496173A (zh) | 2011-09-30 | 2017-03-15 | 沃泰克斯药物股份有限公司 | 用于制备可用作atr激酶抑制剂的化合物的方法 |
| CN108685922A (zh) | 2011-09-30 | 2018-10-23 | 沃泰克斯药物股份有限公司 | 用atr抑制剂治疗胰腺癌和非小细胞肺癌 |
| US8916183B2 (en) * | 2012-02-02 | 2014-12-23 | Dow Agrosciences, Llc. | Pesticidal compositions and processes related thereto |
| CA2861353A1 (en) * | 2012-02-02 | 2013-08-08 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| CN108478577A (zh) | 2012-04-05 | 2018-09-04 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物及其组合疗法 |
| CN104602524A (zh) * | 2012-07-09 | 2015-05-06 | 美国陶氏益农公司 | 杀虫组合物和与其相关的方法 |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| UA118254C2 (uk) | 2012-12-04 | 2018-12-26 | Монсанто Текнолоджи Ллс | Нематоцидні водні композиції концентрату суспензії |
| WO2014163934A1 (en) * | 2013-03-13 | 2014-10-09 | Dow Agrosciences Llc | Preparation of 1,3-(substituted-diaryl)-1,2,4-triazoles |
| US20140275564A1 (en) * | 2013-03-13 | 2014-09-18 | Dow Agrosciences Llc | Process for the preparation of certain triaryl rhamnose carbamates |
| WO2014158649A1 (en) * | 2013-03-13 | 2014-10-02 | Dow Agrosciences Llc | Preparation of 1,3-(substituted-diaryl)-1,2,4-triazoles |
| US20140275563A1 (en) * | 2013-03-13 | 2014-09-18 | Dow Agrosciences Llc | Preparation of 1,3-(substituted-diaryl)-1,2,4-triazoles and intermediates therefrom |
| US9249133B2 (en) * | 2013-03-14 | 2016-02-02 | Dow Agrosciences Llc | Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto |
| ES2651367T3 (es) * | 2013-07-15 | 2018-01-25 | Basf Se | Compuestos plaguicidas |
| CN105828608A (zh) * | 2013-10-22 | 2016-08-03 | 美国陶氏益农公司 | 杀虫组合物和与其相关的方法 |
| KR101658613B1 (ko) * | 2014-04-18 | 2016-09-21 | 에이치설퍼 주식회사 | 친환경 식물병충해 방제용 유황 수화 조성물 및 그 제조방법 |
| TW201603707A (zh) * | 2014-06-24 | 2016-02-01 | 陶氏農業科學公司 | 具有特定殺蟲效用之分子及與其相關之中間物、組成物和製程 |
| TWI653227B (zh) * | 2014-07-11 | 2019-03-11 | Dow Agrosciences Llc | 用於製備4-(1-(4-(全氟乙氧基)苯基)-1h-1,2,4-三唑-3-基)苯甲醯疊氮化物之改良方法 |
| TW201625564A (zh) * | 2014-07-23 | 2016-07-16 | 陶氏農業科學公司 | 具有某些殺蟲效用之分子及與其相關之中間物、組成物及方法(二) |
| TW201625563A (zh) * | 2014-07-28 | 2016-07-16 | 陶氏農業科學公司 | 具有某些殺蟲效用之分子及與其相關之中間物、組成物及方法(一) |
| TWI670012B (zh) * | 2014-07-28 | 2019-09-01 | 美商陶氏農業科學公司 | 具有某些殺蟲效用之分子及與其相關之中間物、組成物及方法 |
| CR20170077A (es) | 2014-08-04 | 2017-06-26 | Nuevolution As | Derivados de heterociclilo opcionalmente condensados de pirimidina útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias |
| US10076117B2 (en) * | 2014-08-28 | 2018-09-18 | Rotam Agrochem International Company Limited | Pesticide formulation comprising a water soluble active ingredient and a penetration enhancer and use of the same |
| RU2565667C1 (ru) * | 2014-10-28 | 2015-10-20 | Михаил Владимирович Дорогов | 2-арилзамещенные n-арилимидазолины селективные ингибиторы циклооксигеназы-2, способы их получения и применения |
| MX2017006136A (es) | 2014-12-15 | 2017-07-19 | Dow Agrosciences Llc | Moleculas que tienen utilidad plaguicida e intermediarios, composiciones y procedimientos relacionados con las mismas. |
| WO2016113261A1 (en) * | 2015-01-13 | 2016-07-21 | Basf Se | Fused tricyclic compounds, compositions comprising these compounds and their use for con-trolling invertebrate pests |
| BR112018003514A2 (pt) * | 2015-09-04 | 2018-09-18 | Dow Agrosciences Llc | moléculas com utilidade pesticida, e intermediários, composições e processos relativos às mesmas |
| WO2017040742A1 (en) * | 2015-09-04 | 2017-03-09 | Dow Agrosciences Llc | Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto |
| AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
| EP3555050A1 (en) | 2016-12-16 | 2019-10-23 | Basf Se | Pesticidal compounds |
| US11191269B2 (en) * | 2017-05-02 | 2021-12-07 | Dow Agrosciences Llc | Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses |
| WO2019005517A1 (en) | 2017-06-28 | 2019-01-03 | Dow Agrosciences Llc | MOLECULES HAVING PESTICIDAL UTILITY AND INTERMEDIATES, COMPOSITIONS AND RELATED METHODS |
| MX2020009830A (es) * | 2018-03-23 | 2020-10-14 | Monsanto Technology Llc | Composiciones nematicidas acuosas que contienen dispersantes para inhibir el crecimiento de cristales. |
| JP6718568B1 (ja) * | 2018-12-14 | 2020-07-08 | 大日本除蟲菊株式会社 | 害虫、ダニ防除方法、及び害虫、ダニ防除用エアゾール |
| TWI901593B (zh) * | 2019-07-17 | 2025-10-21 | 美商科迪華農業科技有限責任公司 | 具有一定殺有害生物效用之分子以及與其相關中間體、組成物及方法 |
| TW202128650A (zh) | 2019-10-11 | 2021-08-01 | 德商拜耳動物保健有限公司 | 作為殺蟲劑之新穎的雜芳基取代之吡𠯤衍生物 |
| UY38994A (es) | 2019-12-20 | 2021-07-30 | Nuevolution As | Compuestos activos frente a receptores nucleares |
| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| WO2021198956A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
| AU2021245397A1 (en) | 2020-03-31 | 2022-10-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CN111990009B (zh) * | 2020-09-11 | 2021-10-29 | 中国科学院成都生物研究所 | 一种促进四川黄栌种子萌芽的方法 |
| CA3220746A1 (en) * | 2021-07-16 | 2023-01-19 | Min Xie | Flea and tick collar |
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| PT1123287E (pt) * | 1998-10-23 | 2003-12-31 | Dow Agrosciences Llc | 1-(piridil substituido)-1,2,4-triazoles insecticidas |
| US6864219B2 (en) * | 2000-01-17 | 2005-03-08 | Bayer Aktiengesellschaft | Substituted aryl ketones |
| US6417187B2 (en) | 2000-04-14 | 2002-07-09 | Dow Agrosciences Llc | 1,2,4-triazole based compounds that can be used as insecticides or acaricides and processes |
| AU2005219788B2 (en) * | 2004-03-05 | 2010-06-03 | Nissan Chemical Corporation | Isoxazoline-substituted benzamide compound and noxious organism control agent |
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| WO2008124092A2 (en) * | 2007-04-03 | 2008-10-16 | E. I. Du Pont De Nemours And Company | Substituted benzene fungicides |
| US20080262057A1 (en) * | 2007-04-20 | 2008-10-23 | Dow Agrosciences Llc | Diarylisoxazolines |
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| UA107671C2 (en) | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| UA108619C2 (xx) | 2009-08-07 | 2015-05-25 | Пестицидні композиції | |
| AU2011293393B2 (en) | 2010-08-26 | 2014-03-06 | Dow Agrosciences Llc | Pesticidal compositions |
| CA2826146A1 (en) | 2011-02-07 | 2012-08-16 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| BR102012002852B1 (pt) | 2011-02-09 | 2018-05-29 | Dow Agrosciences Llc | Composições pesticidas e processos relacionados das mesmas |
| AR087119A1 (es) | 2011-07-12 | 2014-02-12 | Dow Agrosciences Llc | Composiciones plaguicidas y procesos relacionados |
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