BR0317520A - Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase - Google Patents

Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase

Info

Publication number
BR0317520A
BR0317520A BR0317520-0A BR0317520A BR0317520A BR 0317520 A BR0317520 A BR 0317520A BR 0317520 A BR0317520 A BR 0317520A BR 0317520 A BR0317520 A BR 0317520A
Authority
BR
Brazil
Prior art keywords
inhibitors
hmg
transfer protein
compositions
coa reductase
Prior art date
Application number
BR0317520-0A
Other languages
English (en)
Inventor
Walter Christian Babcock
Dwayne Thomas Friesen
Daniel Tod Smithey
Ravi Mysore Shanker
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0317520A publication Critical patent/BR0317520A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçõES DE INIBIDORES DE PROTEìNA DE TRANSFERêNCIA DE éSTERES DE COLESTERILO E INIBIDORES DE HMG-COA REDUTASE". A composição compreende (1) um adsorvato amorfo sólido compreendendo um inibidor de proteína de transferência de ésteres de colesterilo (CETP)e um substrato; e (2) um inibidor de HMG-CoA redutase. O adsorvato amorfo sólido proporciona concentração aumentada do inibidor de CETP em relação a uma composição de controle consistindo essencialmente no inibidor de CETP só não adsorvido, resultando em biodisponibilidade melhorada.
BR0317520-0A 2002-12-20 2003-12-18 Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase BR0317520A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43532802P 2002-12-20 2002-12-20
PCT/IB2003/006170 WO2004056395A1 (en) 2002-12-20 2003-12-18 Compositions of cholesteryl ester transfer protein inhibitors and hmg-coa reductase inhibitors

Publications (1)

Publication Number Publication Date
BR0317520A true BR0317520A (pt) 2005-11-16

Family

ID=32682218

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317520-0A BR0317520A (pt) 2002-12-20 2003-12-18 Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase

Country Status (8)

Country Link
US (1) US20040132771A1 (pt)
EP (1) EP1578448A1 (pt)
JP (1) JP2006512361A (pt)
AU (2) AU2003285677A1 (pt)
BR (1) BR0317520A (pt)
CA (1) CA2510458A1 (pt)
MX (1) MXPA05006167A (pt)
WO (2) WO2004056395A1 (pt)

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Also Published As

Publication number Publication date
WO2004056395A1 (en) 2004-07-08
US20040132771A1 (en) 2004-07-08
MXPA05006167A (es) 2005-08-26
EP1578448A1 (en) 2005-09-28
AU2003285677A1 (en) 2004-07-14
AU2003285703A1 (en) 2004-07-14
CA2510458A1 (en) 2004-07-08
WO2004056396A1 (en) 2004-07-08
JP2006512361A (ja) 2006-04-13

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