BR0317520A - Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase - Google Patents
Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutaseInfo
- Publication number
- BR0317520A BR0317520A BR0317520-0A BR0317520A BR0317520A BR 0317520 A BR0317520 A BR 0317520A BR 0317520 A BR0317520 A BR 0317520A BR 0317520 A BR0317520 A BR 0317520A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- hmg
- transfer protein
- compositions
- coa reductase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSIçõES DE INIBIDORES DE PROTEìNA DE TRANSFERêNCIA DE éSTERES DE COLESTERILO E INIBIDORES DE HMG-COA REDUTASE". A composição compreende (1) um adsorvato amorfo sólido compreendendo um inibidor de proteína de transferência de ésteres de colesterilo (CETP)e um substrato; e (2) um inibidor de HMG-CoA redutase. O adsorvato amorfo sólido proporciona concentração aumentada do inibidor de CETP em relação a uma composição de controle consistindo essencialmente no inibidor de CETP só não adsorvido, resultando em biodisponibilidade melhorada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43532802P | 2002-12-20 | 2002-12-20 | |
PCT/IB2003/006170 WO2004056395A1 (en) | 2002-12-20 | 2003-12-18 | Compositions of cholesteryl ester transfer protein inhibitors and hmg-coa reductase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0317520A true BR0317520A (pt) | 2005-11-16 |
Family
ID=32682218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0317520-0A BR0317520A (pt) | 2002-12-20 | 2003-12-18 | Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase |
Country Status (8)
Country | Link |
---|---|
US (1) | US20040132771A1 (pt) |
EP (1) | EP1578448A1 (pt) |
JP (1) | JP2006512361A (pt) |
AU (2) | AU2003285677A1 (pt) |
BR (1) | BR0317520A (pt) |
CA (1) | CA2510458A1 (pt) |
MX (1) | MXPA05006167A (pt) |
WO (2) | WO2004056395A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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TNSN03139A1 (fr) * | 2001-06-21 | 2005-12-23 | Pfizer Prod Inc | Formulations auto-emulsionnables d'inhibiteurs de la proteine de transfert d'ester de cholesteryle |
CA2509688A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
EA009646B1 (ru) | 2003-05-30 | 2008-02-28 | Рэнбакси Лабораториз Лтд. | Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa |
JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
US20080145427A1 (en) * | 2005-02-03 | 2008-06-19 | Alfred Berchielli | Dosage Forms Providing Controlled and Immediate Release of Cholesteryl Ester Transfer Protein Inhibitors and Immediate Release of Hmg-Coa Reductase Inhibitors |
WO2006085217A2 (en) * | 2005-02-08 | 2006-08-17 | Pfizer Products Inc. | Solid adsorbates of hydrophobic drugs |
US8828438B2 (en) | 2005-05-31 | 2014-09-09 | Bend Research, Inc. | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase |
AU2006313430B2 (en) * | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
TW200744583A (en) * | 2006-03-14 | 2007-12-16 | Ranbaxy Lab Ltd | Statin stabilizing dosage formulations |
WO2007134158A2 (en) * | 2006-05-12 | 2007-11-22 | Drugtech Corporation | Granules comprising calcium carbonate, a binder and a porosity increasing agent, processes of manufacturing, use in therapy |
US8099298B2 (en) * | 2007-02-14 | 2012-01-17 | Genelex, Inc | Genetic data analysis and database tools |
CN102089016A (zh) * | 2008-02-27 | 2011-06-08 | 托门医学股份公司 | 植入物及其制备方法 |
WO2009113522A1 (ja) * | 2008-03-11 | 2009-09-17 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
MX2010013834A (es) * | 2008-06-27 | 2011-02-21 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Composiciones farmaceuticas de calcio de rosuvastatina. |
WO2010092925A1 (ja) * | 2009-02-12 | 2010-08-19 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
WO2012170417A2 (en) | 2011-06-06 | 2012-12-13 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
EP2951741A2 (en) | 2013-02-03 | 2015-12-09 | Genelex Corporation | Systems and methods for quantification and presentation of medical risk arising from unknown factors |
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-
2003
- 2003-10-06 US US10/678,145 patent/US20040132771A1/en not_active Abandoned
- 2003-12-18 WO PCT/IB2003/006170 patent/WO2004056395A1/en active Application Filing
- 2003-12-18 MX MXPA05006167A patent/MXPA05006167A/es not_active Application Discontinuation
- 2003-12-18 EP EP03778668A patent/EP1578448A1/en not_active Withdrawn
- 2003-12-18 BR BR0317520-0A patent/BR0317520A/pt not_active IP Right Cessation
- 2003-12-18 AU AU2003285677A patent/AU2003285677A1/en not_active Abandoned
- 2003-12-18 JP JP2004561920A patent/JP2006512361A/ja active Pending
- 2003-12-18 AU AU2003285703A patent/AU2003285703A1/en not_active Abandoned
- 2003-12-18 WO PCT/IB2003/006240 patent/WO2004056396A1/en not_active Application Discontinuation
- 2003-12-18 CA CA002510458A patent/CA2510458A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004056395A1 (en) | 2004-07-08 |
US20040132771A1 (en) | 2004-07-08 |
MXPA05006167A (es) | 2005-08-26 |
EP1578448A1 (en) | 2005-09-28 |
AU2003285677A1 (en) | 2004-07-14 |
AU2003285703A1 (en) | 2004-07-14 |
CA2510458A1 (en) | 2004-07-08 |
WO2004056396A1 (en) | 2004-07-08 |
JP2006512361A (ja) | 2006-04-13 |
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