BR0315764A - Cristais de análogos da insulina e processo para a sua preparação - Google Patents
Cristais de análogos da insulina e processo para a sua preparaçãoInfo
- Publication number
- BR0315764A BR0315764A BR0315764-4A BR0315764A BR0315764A BR 0315764 A BR0315764 A BR 0315764A BR 0315764 A BR0315764 A BR 0315764A BR 0315764 A BR0315764 A BR 0315764A
- Authority
- BR
- Brazil
- Prior art keywords
- crystals
- angstrom
- chain
- amino acid
- acid residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"CRISTAIS DE ANáLOGOS DA INSULINA E PROCESSO PARA A SUA PREPARAçãO". A presente invenção refere-se a cristais de um análogo da insulina, no qual a asparagina (Asn) na posição B3 da cadeia B é trocada por um radical de aminoácido básico natural e pelo menos um radical de aminoácido das posições B27, B28 ou B29 da cadeia B é trocado por um outro radical de aminoácido neutro ou ácido natural, em que facultativamente a fenilalanina (Phe) na posição B1 da cadeia B pode estar ausente, sendo que os cristais no grupo espacial R3 (n<0> 146) se apresentam com os eixos celulares A=81,5 <143> <sym> 1 <143> e C= 33,3 <143> <sym> 1 <143>, sua preparação e aplicação bem como uma concentração farmacêutica contendo estes cristais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10250297A DE10250297A1 (de) | 2002-10-29 | 2002-10-29 | Kristalle von Insulinanaloga und Verfahren zu ihrer Herstellung |
| PCT/EP2003/011470 WO2004039838A1 (de) | 2002-10-29 | 2003-10-16 | Kristalle von insulinanaloga und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0315764A true BR0315764A (pt) | 2005-09-06 |
Family
ID=32114902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0315764-4A BR0315764A (pt) | 2002-10-29 | 2003-10-16 | Cristais de análogos da insulina e processo para a sua preparação |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1558641B1 (pt) |
| JP (1) | JP4460454B2 (pt) |
| AT (1) | ATE458755T1 (pt) |
| AU (1) | AU2003274018B2 (pt) |
| BR (1) | BR0315764A (pt) |
| CA (1) | CA2503670A1 (pt) |
| CY (1) | CY1112016T1 (pt) |
| DE (2) | DE10250297A1 (pt) |
| DK (1) | DK1558641T3 (pt) |
| ES (1) | ES2340157T3 (pt) |
| IL (1) | IL168141A (pt) |
| MX (1) | MXPA05004440A (pt) |
| PT (1) | PT1558641E (pt) |
| SI (1) | SI1558641T1 (pt) |
| WO (1) | WO2004039838A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2626368B1 (en) * | 2004-07-19 | 2016-12-21 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
| JP2015507916A (ja) * | 2012-01-20 | 2015-03-16 | ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ | グルタミン酸安定化インスリン類似体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
| DE69834028T2 (de) * | 1997-03-20 | 2006-12-07 | Novo Nordisk A/S | Zinkfreie insulinkristalle für die verwendung in medikamenten, die über die lunge verabreicht werden. |
| DE19726167B4 (de) * | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
-
2002
- 2002-10-29 DE DE10250297A patent/DE10250297A1/de not_active Withdrawn
-
2003
- 2003-10-16 DE DE50312454T patent/DE50312454D1/de not_active Expired - Lifetime
- 2003-10-16 JP JP2004547518A patent/JP4460454B2/ja not_active Expired - Fee Related
- 2003-10-16 ES ES03757992T patent/ES2340157T3/es not_active Expired - Lifetime
- 2003-10-16 DK DK03757992.7T patent/DK1558641T3/da active
- 2003-10-16 CA CA002503670A patent/CA2503670A1/en not_active Abandoned
- 2003-10-16 SI SI200331778T patent/SI1558641T1/sl unknown
- 2003-10-16 AT AT03757992T patent/ATE458755T1/de active
- 2003-10-16 EP EP03757992A patent/EP1558641B1/de not_active Expired - Lifetime
- 2003-10-16 BR BR0315764-4A patent/BR0315764A/pt active Search and Examination
- 2003-10-16 MX MXPA05004440A patent/MXPA05004440A/es active IP Right Grant
- 2003-10-16 AU AU2003274018A patent/AU2003274018B2/en not_active Ceased
- 2003-10-16 WO PCT/EP2003/011470 patent/WO2004039838A1/de active Application Filing
- 2003-10-16 PT PT03757992T patent/PT1558641E/pt unknown
-
2005
- 2005-04-19 IL IL168141A patent/IL168141A/en not_active IP Right Cessation
-
2010
- 2010-05-13 CY CY20101100414T patent/CY1112016T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2503670A1 (en) | 2004-05-13 |
| SI1558641T1 (sl) | 2010-04-30 |
| AU2003274018A1 (en) | 2004-05-25 |
| DE10250297A1 (de) | 2004-05-19 |
| EP1558641A1 (de) | 2005-08-03 |
| JP4460454B2 (ja) | 2010-05-12 |
| ATE458755T1 (de) | 2010-03-15 |
| AU2003274018B2 (en) | 2009-08-20 |
| DE50312454D1 (de) | 2010-04-08 |
| ES2340157T3 (es) | 2010-05-31 |
| MXPA05004440A (es) | 2005-07-26 |
| CY1112016T1 (el) | 2015-11-04 |
| EP1558641B1 (de) | 2010-02-24 |
| WO2004039838A1 (de) | 2004-05-13 |
| DK1558641T3 (da) | 2010-06-07 |
| JP2006516536A (ja) | 2006-07-06 |
| PT1558641E (pt) | 2010-04-19 |
| IL168141A (en) | 2012-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2328 DE 18-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |