BR0315241A - Método para melhorar especifica e seletivamente a expressão de gene de mrna de colágeno do tipo ii em tecido de cartilagem, dispositivo e métodos de tratamento de pelo menos uma de osteoartrite, artrite reumatóide, lesão e imperfeições de cartilagem - Google Patents
Método para melhorar especifica e seletivamente a expressão de gene de mrna de colágeno do tipo ii em tecido de cartilagem, dispositivo e métodos de tratamento de pelo menos uma de osteoartrite, artrite reumatóide, lesão e imperfeições de cartilagemInfo
- Publication number
- BR0315241A BR0315241A BR0315241-3A BR0315241A BR0315241A BR 0315241 A BR0315241 A BR 0315241A BR 0315241 A BR0315241 A BR 0315241A BR 0315241 A BR0315241 A BR 0315241A
- Authority
- BR
- Brazil
- Prior art keywords
- cartilage
- gene expression
- specific
- methods
- selective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/267,708 US6919205B2 (en) | 2000-02-23 | 2002-10-09 | Regulation of type II collagen gene expression using specific and selective electrical and electromagnetic signals |
PCT/US2003/031793 WO2004033644A2 (en) | 2002-10-09 | 2003-10-07 | Regulation of type ii collagen gene expression using specific and selective electrical and electromagnetic signals |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0315241A true BR0315241A (pt) | 2005-08-23 |
Family
ID=32068429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0315241-3A BR0315241A (pt) | 2002-10-09 | 2003-10-07 | Método para melhorar especifica e seletivamente a expressão de gene de mrna de colágeno do tipo ii em tecido de cartilagem, dispositivo e métodos de tratamento de pelo menos uma de osteoartrite, artrite reumatóide, lesão e imperfeições de cartilagem |
Country Status (16)
Country | Link |
---|---|
US (1) | US6919205B2 (de) |
EP (1) | EP1575475B1 (de) |
JP (1) | JP2006501853A (de) |
KR (1) | KR20050056233A (de) |
CN (1) | CN1703184A (de) |
AU (1) | AU2003279184A1 (de) |
BR (1) | BR0315241A (de) |
CA (1) | CA2501554C (de) |
CR (1) | CR7789A (de) |
EG (1) | EG23918A (de) |
ES (1) | ES2593307T3 (de) |
MX (1) | MXPA05003785A (de) |
NO (1) | NO20052254L (de) |
NZ (1) | NZ539833A (de) |
WO (1) | WO2004033644A2 (de) |
ZA (1) | ZA200503422B (de) |
Families Citing this family (54)
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US7167748B2 (en) | 1996-01-08 | 2007-01-23 | Impulse Dynamics Nv | Electrical muscle controller |
US8825152B2 (en) | 1996-01-08 | 2014-09-02 | Impulse Dynamics, N.V. | Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue |
US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
US8321013B2 (en) | 1996-01-08 | 2012-11-27 | Impulse Dynamics, N.V. | Electrical muscle controller and pacing with hemodynamic enhancement |
JP4175662B2 (ja) | 1996-01-08 | 2008-11-05 | インパルス ダイナミクス エヌ.ヴイ. | 電気的筋肉制御装置 |
US9713723B2 (en) | 1996-01-11 | 2017-07-25 | Impulse Dynamics Nv | Signal delivery through the right ventricular septum |
US8666495B2 (en) | 1999-03-05 | 2014-03-04 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
US8700161B2 (en) | 1999-03-05 | 2014-04-15 | Metacure Limited | Blood glucose level control |
US7374916B2 (en) | 2000-02-23 | 2008-05-20 | The Trustees Of The University Of Pennsylvania | Regulation of aggrecan gene expression using specific and selective electrical and electromagnetic signals |
US7429471B2 (en) * | 2000-02-23 | 2008-09-30 | The Trustees Of The University Of Pennsylvania | Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals |
US8313908B2 (en) | 2000-02-23 | 2012-11-20 | The Trustees Of The University Of Pennsylvania | Regulation of stem cell gene production with specific and selective electric and electromagnetic fields |
US7465566B2 (en) * | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
US7465546B2 (en) * | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields |
US7981611B2 (en) * | 2000-02-23 | 2011-07-19 | The Trustees Of The University Of Pennsylvania | Regulation of fibroblastic growth factor-2 (FGF-2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields |
US7022506B2 (en) * | 2000-02-23 | 2006-04-04 | The Trustees Of The University Of Pennsylvania | Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee |
US9931503B2 (en) | 2003-03-10 | 2018-04-03 | Impulse Dynamics Nv | Protein activity modification |
US7840262B2 (en) | 2003-03-10 | 2010-11-23 | Impulse Dynamics Nv | Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue |
US11439815B2 (en) | 2003-03-10 | 2022-09-13 | Impulse Dynamics Nv | Protein activity modification |
GB2400316A (en) * | 2003-04-10 | 2004-10-13 | Richard Markoll | Electromagnetic stimulation in patients with osteoporosis |
US8792985B2 (en) | 2003-07-21 | 2014-07-29 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
US10350428B2 (en) | 2014-11-04 | 2019-07-16 | Endonovo Therapetics, Inc. | Method and apparatus for electromagnetic treatment of living systems |
US20130218235A9 (en) * | 2005-03-07 | 2013-08-22 | Arthur A. Pilla | Excessive fibrous capsule formation and capsular contracture apparatus and method for using same |
US9433797B2 (en) | 2003-12-05 | 2016-09-06 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurodegenerative conditions |
US9656096B2 (en) | 2003-12-05 | 2017-05-23 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans |
US7744524B2 (en) * | 2003-12-05 | 2010-06-29 | Ivivi Health Sciences, Llc | Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules |
US9440089B2 (en) | 2003-12-05 | 2016-09-13 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke |
US9415233B2 (en) | 2003-12-05 | 2016-08-16 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological pain |
US20110112352A1 (en) * | 2003-12-05 | 2011-05-12 | Pilla Arthur A | Apparatus and method for electromagnetic treatment |
US8961385B2 (en) | 2003-12-05 | 2015-02-24 | Ivivi Health Sciences, Llc | Devices and method for treatment of degenerative joint diseases with electromagnetic fields |
US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US11779768B2 (en) | 2004-03-10 | 2023-10-10 | Impulse Dynamics Nv | Protein activity modification |
US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
WO2006119467A2 (en) | 2005-05-04 | 2006-11-09 | Impulse Dynamics Nv | Protein activity modification |
NZ551316A (en) * | 2004-04-19 | 2008-03-28 | Ivivi Technologies Inc | Electromagnetic treatment apparatus and method |
US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
US7981065B2 (en) * | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
US7279110B2 (en) * | 2004-12-27 | 2007-10-09 | Asml Holding N.V. | Method and apparatus for creating a phase step in mirrors used in spatial light modulator arrays |
WO2006097934A2 (en) | 2005-03-18 | 2006-09-21 | Metacure Limited | Pancreas lead |
US7840272B2 (en) * | 2005-06-03 | 2010-11-23 | Medrelief Inc. | Methods for modulating osteochondral development using bioelectrical stimulation |
US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
US20070190028A1 (en) * | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
US20090018613A1 (en) * | 2006-08-02 | 2009-01-15 | Genestim, Llc | Regulation of vascular endothelial growth factor (vegf) gene expression in tissue via the application of electric and/or electromagnetic fields |
US8934975B2 (en) | 2010-02-01 | 2015-01-13 | Metacure Limited | Gastrointestinal electrical therapy |
CN101891803B (zh) * | 2010-07-15 | 2012-09-05 | 北京大学第三医院 | 一种软骨亲和多肽序列、其筛选方法及应用 |
WO2012045079A2 (en) | 2010-10-01 | 2012-04-05 | Ivivi Health Sciences, Llc | Method and apparatus for electromagnetic treatment of head cerebral and neural injury in animals and humans |
US8795147B1 (en) | 2010-10-07 | 2014-08-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Modifying the genetic regulation of bone and cartilage cells and associated tissue by EMF stimulation fields and uses thereof |
US9896681B2 (en) | 2010-10-07 | 2018-02-20 | The United States Of America As Represented By The National Aeronautics And Space Administration | Genetic regulation of bone and cells by electromagnetic stimulation fields and uses thereof |
US8343027B1 (en) | 2012-01-30 | 2013-01-01 | Ivivi Health Sciences, Llc | Methods and devices for providing electromagnetic treatment in the presence of a metal-containing implant |
US9320913B2 (en) | 2014-04-16 | 2016-04-26 | Rio Grande Neurosciences, Inc. | Two-part pulsed electromagnetic field applicator for application of therapeutic energy |
EP3481495A4 (de) * | 2016-07-07 | 2020-04-29 | Venus Concept Ltd | Zur erhöhung der hautverjüngung nützliche, ästhetische vorrichtung und verfahren dafür |
WO2018089795A1 (en) | 2016-11-10 | 2018-05-17 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
CN110604098B (zh) * | 2019-09-23 | 2021-09-07 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 一种类风湿关节炎合并间质性肺病动物模型的构建方法 |
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US4509520A (en) * | 1982-02-22 | 1985-04-09 | Biolectron, Inc. | Electrical stimulating apparatus |
US5269746A (en) * | 1982-12-20 | 1993-12-14 | Jacobson Jerry I | Therapeutic treatment of mammals for epilepsy and Parkinson's disease |
US4535775A (en) * | 1983-02-10 | 1985-08-20 | Biolectron, Inc. | Method for treatment of non-union bone fractures by non-invasive electrical stimulation |
IT1159024B (it) * | 1983-06-02 | 1987-02-25 | Ruggero Cadossi | Metodo e dispositivo per il trattamento di tessuti e cellule viventi mediante campi elettromagnetici pulsanti |
US4600010A (en) * | 1984-10-04 | 1986-07-15 | Biolectron, Inc. | Electric stimulator and test instrument therefor |
US5014699A (en) * | 1986-05-23 | 1991-05-14 | Trustees Of The University Of Pennsylvania | Electromagnetic method and apparatus for healing living tissue |
US5038797A (en) * | 1990-02-20 | 1991-08-13 | Romaine, Incorporated | Electrical stimulation treatment device and method of use |
US5273033A (en) * | 1991-09-19 | 1993-12-28 | Murray Electronics Associates Limited Partnership | Electrical stimulation for treatment of osteoarthritis |
US5338286A (en) * | 1992-12-08 | 1994-08-16 | Electro-Biology, Inc. | Electromagnetic bioresponse by selective spectral suppression in pulsed field stimulation |
US5374283A (en) * | 1993-12-01 | 1994-12-20 | Flick; A. Bart | Electrical therapeutic apparatus |
US5743844A (en) * | 1996-11-01 | 1998-04-28 | Amei Technologies, Inc. | High efficiency pulsed electromagnetic field (PEMF) stimulation therapy method and system |
US6132362A (en) * | 1996-11-01 | 2000-10-17 | Amei Technologies, Inc. | Pulsed electromagnetic field (PEMF) stimulation therapy system with bi-phasic coil |
US6261221B1 (en) * | 1996-11-01 | 2001-07-17 | Amei Technologies Inc. | Flexible coil pulsed electromagnetic field (PEMF) stimulation therapy system |
US5968527A (en) * | 1997-02-27 | 1999-10-19 | Catholic University Of America, The | Protection of living systems from the adverse effects of stress |
US6083149A (en) * | 1997-10-22 | 2000-07-04 | Emf Therapeutics, Inc. | Magnetic field device and method for inhibiting angiogenesis and retarding growth rates of tumors in mammals |
US6186940B1 (en) * | 1998-05-18 | 2001-02-13 | Robert N. Kirschbaum | Energized trace elements |
US7465566B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
US6485963B1 (en) * | 2000-06-02 | 2002-11-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof |
-
2002
- 2002-10-09 US US10/267,708 patent/US6919205B2/en not_active Ceased
-
2003
- 2003-10-07 JP JP2004543486A patent/JP2006501853A/ja not_active Withdrawn
- 2003-10-07 WO PCT/US2003/031793 patent/WO2004033644A2/en active Application Filing
- 2003-10-07 CN CNA2003801012218A patent/CN1703184A/zh active Pending
- 2003-10-07 KR KR1020057006097A patent/KR20050056233A/ko not_active Application Discontinuation
- 2003-10-07 EP EP03770683.5A patent/EP1575475B1/de not_active Expired - Lifetime
- 2003-10-07 BR BR0315241-3A patent/BR0315241A/pt not_active IP Right Cessation
- 2003-10-07 ES ES03770683.5T patent/ES2593307T3/es not_active Expired - Lifetime
- 2003-10-07 CA CA2501554A patent/CA2501554C/en not_active Expired - Fee Related
- 2003-10-07 MX MXPA05003785A patent/MXPA05003785A/es not_active Application Discontinuation
- 2003-10-07 NZ NZ539833A patent/NZ539833A/en not_active IP Right Cessation
- 2003-10-07 AU AU2003279184A patent/AU2003279184A1/en not_active Abandoned
-
2005
- 2005-04-08 CR CR7789A patent/CR7789A/es not_active Application Discontinuation
- 2005-04-09 EG EGNA2005000119 patent/EG23918A/xx active
- 2005-04-28 ZA ZA200503422A patent/ZA200503422B/en unknown
- 2005-05-06 NO NO20052254A patent/NO20052254L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20052254D0 (no) | 2005-05-06 |
US20040073260A1 (en) | 2004-04-15 |
JP2006501853A (ja) | 2006-01-19 |
EP1575475B1 (de) | 2016-06-29 |
ES2593307T3 (es) | 2016-12-07 |
US6919205B2 (en) | 2005-07-19 |
MXPA05003785A (es) | 2005-09-20 |
CN1703184A (zh) | 2005-11-30 |
CA2501554A1 (en) | 2004-04-22 |
CR7789A (es) | 2005-10-05 |
ZA200503422B (en) | 2006-12-27 |
EP1575475A2 (de) | 2005-09-21 |
KR20050056233A (ko) | 2005-06-14 |
WO2004033644A3 (en) | 2004-09-23 |
WO2004033644A2 (en) | 2004-04-22 |
NZ539833A (en) | 2008-08-29 |
AU2003279184A1 (en) | 2004-05-04 |
EP1575475A4 (de) | 2007-10-10 |
EG23918A (en) | 2007-12-30 |
NO20052254L (no) | 2005-07-04 |
CA2501554C (en) | 2014-08-05 |
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