BR0314811A - Composto, uso do mesmo, e, intermediário de sìntese - Google Patents

Composto, uso do mesmo, e, intermediário de sìntese

Info

Publication number
BR0314811A
BR0314811A BR0314811-4A BR0314811A BR0314811A BR 0314811 A BR0314811 A BR 0314811A BR 0314811 A BR0314811 A BR 0314811A BR 0314811 A BR0314811 A BR 0314811A
Authority
BR
Brazil
Prior art keywords
compound
compounds
synthesis intermediate
synthesis
therapy
Prior art date
Application number
BR0314811-4A
Other languages
English (en)
Inventor
Yves Lamberty
Christophe Genicot
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of BR0314811A publication Critical patent/BR0314811A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"COMPOSTO USO DO MESMO E, INTERMEDIáRIO DE SìNTESE". A presente invenção refere-se a derivados de 4-aminopiperidina, a processos para a preparação dos mesmos e ao uso dos mesmos em terapia e a composições farmacêuticas que contêm os mesmos. Mais particularmente estes compostos são úteis para o tratamento de distúrbios do sistema nervoso central e/ou periférico. De particular interesse é a potente atividade antidepressiva apresentada por estes compostos.
BR0314811-4A 2002-10-04 2003-09-30 Composto, uso do mesmo, e, intermediário de sìntese BR0314811A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02022191 2002-10-04
PCT/EP2003/010824 WO2004030668A1 (en) 2002-10-04 2003-09-30 4-aminopiperidine derivatives, processes for their preparation and their use as medicaments

Publications (1)

Publication Number Publication Date
BR0314811A true BR0314811A (pt) 2005-08-02

Family

ID=32049973

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314811-4A BR0314811A (pt) 2002-10-04 2003-09-30 Composto, uso do mesmo, e, intermediário de sìntese

Country Status (21)

Country Link
US (1) US7488741B2 (pt)
EP (2) EP1556045B1 (pt)
JP (1) JP2006513151A (pt)
KR (1) KR20050055748A (pt)
CN (1) CN1688307A (pt)
AT (1) ATE334680T1 (pt)
AU (1) AU2003270291A1 (pt)
BR (1) BR0314811A (pt)
CA (1) CA2500664A1 (pt)
DE (1) DE60307308T2 (pt)
DK (1) DK1556045T3 (pt)
ES (1) ES2268406T3 (pt)
MX (1) MXPA05003290A (pt)
NO (1) NO20052172L (pt)
NZ (1) NZ539015A (pt)
PL (1) PL376368A1 (pt)
PT (1) PT1556045E (pt)
RU (1) RU2005110409A (pt)
SI (1) SI1556045T1 (pt)
WO (1) WO2004030668A1 (pt)
ZA (1) ZA200502330B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079554A1 (en) * 2002-12-06 2006-04-13 Barry Peter C Inhibitors of monomine uptake
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake
WO2005053663A2 (en) * 2003-11-24 2005-06-16 Eli Lilly And Company Norepinephrine reuptake inhibitors useful for treatment of cognitive failure
EP1756050A1 (en) * 2004-06-01 2007-02-28 Eli Lilly And Company Aminomethyl-azacycle derivatives as inhibitors of monoamine uptake
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
WO2014152229A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
CA3102077A1 (en) 2018-05-31 2019-12-05 Sanjeev AHUJA Method of reducing pulmonary exacerbations in respiratory disease patients
CN111233751B (zh) * 2020-03-25 2021-02-02 丽水绿氟科技有限公司 一种3,3-二氟-4-氨基哌啶类化合物及其衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG12406A (en) * 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
JPH05148234A (ja) * 1991-10-02 1993-06-15 Hokuriku Seiyaku Co Ltd アルカン酸誘導体
DE4404183A1 (de) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-Amino-1-piperidylbenzoylguanidine
GB0108876D0 (en) * 2001-04-09 2001-05-30 Novartis Ag Organic Compounds

Also Published As

Publication number Publication date
AU2003270291A1 (en) 2004-04-23
NO20052172L (no) 2005-06-30
DE60307308D1 (de) 2006-09-14
US7488741B2 (en) 2009-02-10
ZA200502330B (en) 2006-05-31
NZ539015A (en) 2006-02-24
DK1556045T3 (da) 2006-11-27
ATE334680T1 (de) 2006-08-15
WO2004030668A1 (en) 2004-04-15
ES2268406T3 (es) 2007-03-16
EP1693061A1 (en) 2006-08-23
EP1556045A1 (en) 2005-07-27
NO20052172D0 (no) 2005-05-03
CN1688307A (zh) 2005-10-26
US20060128753A1 (en) 2006-06-15
MXPA05003290A (es) 2005-07-05
SI1556045T1 (sl) 2007-02-28
JP2006513151A (ja) 2006-04-20
KR20050055748A (ko) 2005-06-13
PT1556045E (pt) 2006-12-29
DE60307308T2 (de) 2006-12-28
CA2500664A1 (en) 2004-04-15
PL376368A1 (en) 2005-12-27
RU2005110409A (ru) 2005-09-10
EP1556045B1 (en) 2006-08-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2069 DE 31/08/2010.