BR0312426A - Composição farmacêutica, métodos para tratar, prevenir ou controlar um colesterol, dislipidemia ou distúrbio relacionado, para reduzir ou evitar um efeito adverso associado com monoterapia de pantetina e para reduzir ou evitar um efeito adverso associado com monoterapia de segundo agente ativo, e, kit - Google Patents
Composição farmacêutica, métodos para tratar, prevenir ou controlar um colesterol, dislipidemia ou distúrbio relacionado, para reduzir ou evitar um efeito adverso associado com monoterapia de pantetina e para reduzir ou evitar um efeito adverso associado com monoterapia de segundo agente ativo, e, kitInfo
- Publication number
- BR0312426A BR0312426A BR0312426-6A BR0312426A BR0312426A BR 0312426 A BR0312426 A BR 0312426A BR 0312426 A BR0312426 A BR 0312426A BR 0312426 A BR0312426 A BR 0312426A
- Authority
- BR
- Brazil
- Prior art keywords
- prevent
- reduce
- adverse effect
- effect associated
- monotherapy
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 6
- 208000032928 Dyslipidaemia Diseases 0.000 title abstract 3
- 208000017170 Lipid metabolism disease Diseases 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 title abstract 3
- 230000002411 adverse Effects 0.000 title abstract 3
- 235000012000 cholesterol Nutrition 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 title abstract 2
- 229960000903 pantethine Drugs 0.000 title abstract 2
- 235000008975 pantethine Nutrition 0.000 title abstract 2
- 239000011581 pantethine Substances 0.000 title abstract 2
- 238000009097 single-agent therapy Methods 0.000 title 2
- 238000012544 monitoring process Methods 0.000 abstract 2
- 229940123208 Biguanide Drugs 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 229940100389 Sulfonylurea Drugs 0.000 abstract 1
- 150000004283 biguanides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract
"COMPOSIçãO FARMACêUTICA, MéTODOS PARA TRATAR, PREVENIR OU CONTROLAR UM COLESTEROL, DISLIPIDEMIA OU DISTúRBIO RELACIONADO, PARA REDUZIR OU EVITAR UM EFEITO ADVERSO ASSOCIADO COM MONOTERAPIA DE PANTETINA E PARA REDUZIR OU EVITAR UM EFEITO ADVERSO ASSOCIADO COM MONOTERAPIA DE SEGUNDO AGENTE ATIVO, E, KIT". A invenção refere-se, em parte, às composições farmacêuticas que compreendem uma combinação de pantetina, ou um seu derivado, e um segundo agente ativo. Exemplos de segundos agentes ativos incluem, mas não se limitam a, estatinas, fibratos, glitazonas, biguanidas, sulfonil-uréias, compostos de controle de dislipidemia, peptídeos pequenos da invenção, e suas combinações. A invenção também se refere aos métodos para tratar, prevenir, ou controlar colesterol, dislipidemia, e distúrbios relacionados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39318402P | 2002-07-03 | 2002-07-03 | |
PCT/US2003/020780 WO2004004774A2 (en) | 2002-07-03 | 2003-07-02 | Compositions comprising panthetine for the treatment of dyslipidemia |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312426A true BR0312426A (pt) | 2005-12-06 |
Family
ID=30115554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0312426-6A BR0312426A (pt) | 2002-07-03 | 2003-07-02 | Composição farmacêutica, métodos para tratar, prevenir ou controlar um colesterol, dislipidemia ou distúrbio relacionado, para reduzir ou evitar um efeito adverso associado com monoterapia de pantetina e para reduzir ou evitar um efeito adverso associado com monoterapia de segundo agente ativo, e, kit |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050101565A1 (pt) |
EP (1) | EP1519751A2 (pt) |
JP (1) | JP2006509722A (pt) |
AU (1) | AU2003248786A1 (pt) |
BR (1) | BR0312426A (pt) |
CA (1) | CA2491382A1 (pt) |
MX (1) | MXPA05000050A (pt) |
WO (1) | WO2004004774A2 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI284529B (en) * | 2000-12-18 | 2007-08-01 | Sankyo Co | A composition for lowering triglyceride |
CN1938012A (zh) * | 2004-03-31 | 2007-03-28 | 兴和株式会社 | 外用剂 |
JP2008509154A (ja) | 2004-08-06 | 2008-03-27 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 新規なスタチン薬剤組成物および関連治療方法 |
US7906499B2 (en) * | 2005-01-29 | 2011-03-15 | Children's Hospital & Research Center At Oakland | Polycarboxylated porphyrins and use thereof in treatment of metal toxicities |
CN1332657C (zh) * | 2005-01-31 | 2007-08-22 | 杭州鑫富药业有限公司 | 一种含洛伐他汀的组合物及其用途 |
US20070014866A1 (en) * | 2005-07-15 | 2007-01-18 | Curt Hendrix | Composition for improving the efficacy and reducing the side effects of omega 3 fatty acids, fish oils and cardiovascular and diabetic treatments |
BRPI0613670A2 (pt) * | 2005-07-22 | 2011-01-25 | Procter & Gamble | composições para redução da incidência de arritmia induzida por fármacos |
US20070105793A1 (en) * | 2005-11-04 | 2007-05-10 | Curt Hendrix | Compositions and methods using nicotinic acid for treatment of hypercholesterolemia, hyperlipidemia nd cardiovascular disease |
EP1976496A1 (fr) * | 2006-01-23 | 2008-10-08 | Cerebel SA | Approche therapeutique globale dans le traitement des maladies neurodegeneratives |
ES2376396T3 (es) * | 2006-06-26 | 2012-03-13 | Amgen Inc. | Método para tratar aterosclerosis. |
EA021275B9 (ru) | 2009-09-03 | 2015-08-31 | Байоэнердженикс | Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение для лечения pask-опосредованного заболевания |
JP5947041B2 (ja) * | 2011-01-07 | 2016-07-06 | 第一三共ヘルスケア株式会社 | 安全なil−17産生抑制剤 |
US10149855B2 (en) * | 2014-02-05 | 2018-12-11 | The Trustees Of Columbia University In The City Of New York | Gamma-secretase inhibition reduce APOC3 levels and plasma triglycerides |
WO2015183794A1 (en) * | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
CN104231013B (zh) * | 2014-08-26 | 2016-06-29 | 上海现代哈森(商丘)药业有限公司 | 一种天麻素阿魏酸酯类化合物及其制备方法与应用 |
US10017529B2 (en) | 2014-09-16 | 2018-07-10 | BioPharma Works LLC | Metformin derivatives |
SI24899A (sl) | 2014-12-23 | 2016-06-30 | Acies Bio D.O.O. | Fosfopanteteinske spojine,same ali v kombinaciji z inhibitorji HMG-COA reduktaze za zniževanje serumskega holesterola in serumskih trigliceridov |
PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
CN109310653A (zh) | 2016-03-17 | 2019-02-05 | 硫创治疗公司 | 用于控制释放半胱胺和系统治疗半胱胺敏感性病症的组合物 |
CA3076392A1 (en) | 2017-09-20 | 2019-03-28 | Thiogenesis Therapeutics, Inc. | Methods for the treatment of cysteamine sensitive disorders |
WO2021150958A1 (en) * | 2020-01-24 | 2021-07-29 | Schelling D Christopher | Treatment methods using a combination of pantethine and a vanin agonist |
CN113861021B (zh) * | 2021-10-28 | 2024-01-30 | 海南师范大学 | 一种不饱和脂肪酸类化合物及其分离方法和应用 |
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JP2999579B2 (ja) * | 1990-07-18 | 2000-01-17 | 武田薬品工業株式会社 | Dnaおよびその用途 |
US6004925A (en) * | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6083497A (en) * | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
ATE384035T1 (de) * | 1999-04-01 | 2008-02-15 | Esperion Therapeutics Inc | Ether-verbindungen, zusammensetzungen und ihre verwendung |
WO2001051088A1 (en) * | 2000-01-07 | 2001-07-19 | Anthony Cincotta | Composition for reducing plasma triglycerides, platelet aggregation, and oxidative capacity |
CA2428204A1 (en) * | 2000-11-07 | 2002-05-16 | Sankyo Company, Limited | Lipid peroxide-lowering compositions |
CN1287787C (zh) * | 2000-12-14 | 2006-12-06 | 三共株式会社 | 血液脂质改善剂组合物 |
AU2002221131A1 (en) * | 2000-12-14 | 2002-06-24 | Sankyo Company Limited | Blood lipid ameliorant composition |
TWI284529B (en) * | 2000-12-18 | 2007-08-01 | Sankyo Co | A composition for lowering triglyceride |
-
2003
- 2003-07-02 JP JP2004519749A patent/JP2006509722A/ja not_active Ceased
- 2003-07-02 CA CA002491382A patent/CA2491382A1/en not_active Abandoned
- 2003-07-02 WO PCT/US2003/020780 patent/WO2004004774A2/en not_active Application Discontinuation
- 2003-07-02 MX MXPA05000050A patent/MXPA05000050A/es unknown
- 2003-07-02 EP EP03763098A patent/EP1519751A2/en not_active Withdrawn
- 2003-07-02 BR BR0312426-6A patent/BR0312426A/pt not_active Application Discontinuation
- 2003-07-02 US US10/610,682 patent/US20050101565A1/en not_active Abandoned
- 2003-07-02 AU AU2003248786A patent/AU2003248786A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2491382A1 (en) | 2004-01-15 |
EP1519751A2 (en) | 2005-04-06 |
US20050101565A1 (en) | 2005-05-12 |
WO2004004774A3 (en) | 2004-04-15 |
AU2003248786A8 (en) | 2004-01-23 |
WO2004004774A2 (en) | 2004-01-15 |
AU2003248786A1 (en) | 2004-01-23 |
JP2006509722A (ja) | 2006-03-23 |
MXPA05000050A (es) | 2005-04-08 |
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