BR0309174A - Preparação terapêutica na forma de pó seco - Google Patents

Preparação terapêutica na forma de pó seco

Info

Publication number
BR0309174A
BR0309174A BR0309174-0A BR0309174A BR0309174A BR 0309174 A BR0309174 A BR 0309174A BR 0309174 A BR0309174 A BR 0309174A BR 0309174 A BR0309174 A BR 0309174A
Authority
BR
Brazil
Prior art keywords
nozzle
dose
powder
dry powder
air
Prior art date
Application number
BR0309174-0A
Other languages
English (en)
Inventor
Myrman Mattias
Nilsson Per-Gunnar
Original Assignee
Microdrug Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microdrug Ag filed Critical Microdrug Ag
Publication of BR0309174A publication Critical patent/BR0309174A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/005—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a cylindrical surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PREPARAçãO TERAPêUTICA NA FORMA DE Pó SECO". A presente invenção divulga uma preparação terapêutica na forma de pó seco e um método de administração de tal preparação, para efetivamente desagregar e dispersar no ar uma dose de pó de medicamento em uma administração de uma dose a um usuário. A presente preparação de pó seco e respectivo método não requerem outras fontes de energia, além da energia de um esforço de inalação realizado por um usuário para produzir um grau bastante alto de desagregação e eficiente dispersão no ar da dose de medicamento de pó seco. Utilizando um esforço de sucção de ar através de um bocal, as partículas da dose de pó terapêutico tornadas disponíveis para o bocal são gradualmente desagregadas e dispersas numa corrente de ar que entra no bocal. A gradual desagregação e dispersão e produzida por um efeito de arraste, devido a um movimento relativo introduzido entre o bocal e a dose de pó. O bocal é geralmente posicionado externamente à área de pó e não entra em contato com o pó até que a corrente de ar dentro do bocal, criada pela sucção, tenha passado uma velocidade de fluxo limite. Coincidentemente com a aplicação da sucção, o movimento relativo irá começar de modo que o bocal cruze a dose de pó gradualmente. Esforços de cisalhamento e inércia da corrente de ar aplicada são tão poderosos que partículas nos agregados de partículas da dose de pó adjacente à admissão do bocal em movimento são liberadas e desagregadas em alto grau, assim como dispersas e subseq³entemente arrastadas na corrente de ar criada, que se dirigia através do bocal para o usuário da inalação.
BR0309174-0A 2002-04-12 2003-04-04 Preparação terapêutica na forma de pó seco BR0309174A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201125A SE524990C2 (sv) 2002-04-12 2002-04-12 Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver
PCT/SE2003/000540 WO2003086516A1 (en) 2002-04-12 2003-04-04 Therapeutic dry powder preparation

Publications (1)

Publication Number Publication Date
BR0309174A true BR0309174A (pt) 2005-02-09

Family

ID=20287575

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309174-0A BR0309174A (pt) 2002-04-12 2003-04-04 Preparação terapêutica na forma de pó seco

Country Status (12)

Country Link
US (1) US6881398B2 (pt)
EP (1) EP1496967A1 (pt)
JP (1) JP2005522494A (pt)
KR (1) KR20040097351A (pt)
AU (1) AU2003222538B2 (pt)
BR (1) BR0309174A (pt)
CA (1) CA2482263A1 (pt)
MX (1) MXPA04010003A (pt)
RU (1) RU2333014C2 (pt)
SE (1) SE524990C2 (pt)
WO (1) WO2003086516A1 (pt)
ZA (1) ZA200408941B (pt)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
SE524957C2 (sv) * 2002-04-12 2004-11-02 Microdrug Ag Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
AU2004294889B2 (en) * 2003-12-03 2010-08-26 Boehringer Ingelheim International Gmbh Medical product containing tiotropium
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SE0303571D0 (sv) * 2003-12-03 2003-12-22 Microdrug Ag Medical product for moisture-sensitive medicaments
SE0303569L (sv) * 2003-12-03 2005-06-04 Microdrug Ag DPI för avlämning av fuktkänsliga medikament
BRPI0507884A (pt) * 2004-02-24 2007-08-07 Microdose Technologies Inc método e equipamento para administração de medicamento com base em jato sintético
SE528121C2 (sv) * 2004-03-29 2006-09-05 Mederio Ag Preparering av torrpulver för på förhand uppmätt DPI
SE530006C2 (sv) * 2004-06-18 2008-02-05 Mederio Ag Inhalator som använder balja
SE0402345L (sv) * 2004-09-24 2006-03-25 Mederio Ag Uppmätt läkemedelsdos
SE0402976L (sv) * 2004-12-03 2006-06-04 Mederio Ag Medicinsk produkt
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
US20070101991A1 (en) * 2005-11-08 2007-05-10 Mederio Ag Optimizing release of dry medicament powder
GB0616299D0 (en) * 2006-08-16 2006-09-27 Cambridge Consultants Drug Capsules for dry power inhalers
EP2668970B1 (en) * 2006-10-25 2016-07-06 Novartis AG Powder dispersion apparatus
US8196576B2 (en) * 2007-02-28 2012-06-12 Microdose Therapeutx, Inc. Inhaler
JP5813323B2 (ja) * 2007-10-24 2015-11-17 マンカインド コーポレイション 活性薬剤の送達方法
EP2230934B8 (en) 2007-12-14 2012-10-24 AeroDesigns, Inc Delivering aerosolizable food products
RU2457855C2 (ru) * 2008-08-05 2012-08-10 Виктор Владимирович Чалов Противовирусная и антимикробная композиция
WO2010135672A1 (en) * 2009-05-21 2010-11-25 Microdose Therapeutx, Inc. Rotary cassette system for dry powder inhaler
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
EP3431128A1 (en) 2010-01-05 2019-01-23 MicroDose Therapeutx, Inc. Inhalation device and method
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US11554229B2 (en) 2013-03-26 2023-01-17 OptiNose Inc. Nasal administration
ES2920802T3 (es) * 2013-03-26 2022-08-09 Optinose As Administración nasal
EP3607941A1 (en) 2013-04-30 2020-02-12 Otitopic Inc. Dry powder formulations and methods of use
PL3107548T3 (pl) 2014-02-20 2022-10-31 Otitopic Inc. Suche formulacje w proszku do inhalacji
US10307550B2 (en) 2014-06-09 2019-06-04 Dance Biopharm Inc. Liquid drug cartridges and associated dispenser
GB2535427A (en) 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
GB2542838B (en) * 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
WO2018071443A1 (en) 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof

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EP0470154B1 (en) 1989-04-28 1996-06-05 Riker Laboratories, Inc. Dry powder inhalation device
GB9024760D0 (en) 1990-11-14 1991-01-02 Riker Laboratories Inc Inhalation device and medicament carrier
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SE517806C2 (sv) * 1999-11-11 2002-07-16 Microdrug Ag Doseringsanordning för inhalator
SE0002822L (sv) 2000-08-04 2002-01-29 Microdrug Ag Elektropulver
SE516554C2 (sv) 2000-08-31 2002-01-29 Microdrug Ag Uppmätt elektrodos
SE524957C2 (sv) * 2002-04-12 2004-11-02 Microdrug Ag Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament

Also Published As

Publication number Publication date
SE0201125D0 (sv) 2002-04-12
AU2003222538B2 (en) 2007-05-03
SE524990C2 (sv) 2004-11-09
EP1496967A1 (en) 2005-01-19
ZA200408941B (en) 2007-12-27
RU2004132859A (ru) 2005-08-27
US6881398B2 (en) 2005-04-19
KR20040097351A (ko) 2004-11-17
JP2005522494A (ja) 2005-07-28
MXPA04010003A (es) 2005-07-01
RU2333014C2 (ru) 2008-09-10
US20030192540A1 (en) 2003-10-16
SE0201125L (sv) 2003-10-13
CA2482263A1 (en) 2003-10-23
AU2003222538A1 (en) 2003-10-27
WO2003086516A1 (en) 2003-10-23

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: MEDERIO AG (CH)

Free format text: TRANSFERIDO DE: MICRODRUG AG

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 7A, 8A E 9A ANUIDADES.