BR0309152A - composto ou sais, solvatos, hidratos ou pró-drogas deste farmaceuticamente aceitáveis, composição, métodos para tratar ou prevenir uma doença ou condição, uma doença cardiovascular, uma dislipidemia, a hipertensão, o cáncer, a inflamação, e a impotência em um paciente, forma de dosagem unitária, e, método para identificar um composto útil para tratar ou prevenir uma condição em um paciente - Google Patents
composto ou sais, solvatos, hidratos ou pró-drogas deste farmaceuticamente aceitáveis, composição, métodos para tratar ou prevenir uma doença ou condição, uma doença cardiovascular, uma dislipidemia, a hipertensão, o cáncer, a inflamação, e a impotência em um paciente, forma de dosagem unitária, e, método para identificar um composto útil para tratar ou prevenir uma condição em um pacienteInfo
- Publication number
- BR0309152A BR0309152A BRPI0309152-0A BR0309152A BR0309152A BR 0309152 A BR0309152 A BR 0309152A BR 0309152 A BR0309152 A BR 0309152A BR 0309152 A BR0309152 A BR 0309152A
- Authority
- BR
- Brazil
- Prior art keywords
- treating
- disease
- preventing
- patient
- condition
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 7
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 3
- 208000032928 Dyslipidaemia Diseases 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 title abstract 2
- 208000017170 Lipid metabolism disease Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 239000002552 dosage form Substances 0.000 title abstract 2
- 150000004677 hydrates Chemical class 0.000 title abstract 2
- 201000001881 impotence Diseases 0.000 title abstract 2
- 230000004054 inflammatory process Effects 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- 239000012453 solvate Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 1
- -1 Acyl coenzyme A Chemical compound 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005516 coenzyme A Substances 0.000 abstract 1
- 229940093530 coenzyme a Drugs 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
- 208000018914 glucose metabolism disease Diseases 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229940075461 other therapeutic product in atc Drugs 0.000 abstract 1
- 208000013223 septicemia Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
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- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
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- C07C215/12—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by hydroxy groups
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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Abstract
"COMPOSTO OU SAIS, SOLVATOS, HIDRATOS OU PRó-DROGAS DESTE FARMACEUTICAMENTE ACEITáVEIS, COMPOSIçãO, MéTODOS PARA TRATAR OU PREVENIR UMA DOENçA OU CONDIçãO, UMA DOENçA CARDIOVASCULAR, UMA DISLIPIDEMIA, A HIPERTENSãO, O CáNCER, A INFLAMAçãO, E A IMPOTêNCIA EM UM PACIENTE, FORMA DE DOSAGEM UNITáRIA, E, MéTODO PARA IDENTIFICAR UM COMPOSTO úTIL PARA TRATAR OU PREVENIR UMA CONDIçãO EM UM PACIENTE". A invenção diz respeito a novas imitações da Acil coenzima A, às composições que compreendem os compostos de cetona e aos métodos úteis para tratar e prevenir doenças cardiovasculares, dislipidemias, disproteinemias e distúrbios do metabolismo de glicose que compreendem administrar uma composição que compreende um composto de cetona. As imitações da Acil coenzima A, as composições e métodos da invenção também são úteis para tratar e prevenir o Mal de Alzheimer, a Síndrome X, os distúrbios relacionados com o receptor ativado do proliferador de peroxissoma, a septicemia, os distúrbios trombóticos, a obesidade, a pancreatite, a hipertensão, a doença renal, o câncer, a inflamação, a infecção bacteriana e a impotência. Em certas formas de realização, as imitações da Acil coenzima A, as composições e métodos da invenção são úteis na terapia de combinação com outros produtos terapêuticos, tais como agentes hipocolesterolêmicos e hipoglicêmicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37151102P | 2002-04-10 | 2002-04-10 | |
PCT/US2003/011467 WO2003087108A2 (en) | 2002-04-10 | 2003-04-10 | Mimics of acyl coenzyme-a, compositions thereof, and methods of cholesterol management and related uses |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0309152A true BR0309152A (pt) | 2007-01-30 |
Family
ID=29250692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0309152-0A BR0309152A (pt) | 2002-04-10 | 2003-04-10 | composto ou sais, solvatos, hidratos ou pró-drogas deste farmaceuticamente aceitáveis, composição, métodos para tratar ou prevenir uma doença ou condição, uma doença cardiovascular, uma dislipidemia, a hipertensão, o cáncer, a inflamação, e a impotência em um paciente, forma de dosagem unitária, e, método para identificar um composto útil para tratar ou prevenir uma condição em um paciente |
Country Status (8)
Country | Link |
---|---|
US (2) | US20030236212A1 (pt) |
EP (2) | EP1495034A2 (pt) |
JP (2) | JP2005522509A (pt) |
AU (2) | AU2003230918A1 (pt) |
BR (1) | BR0309152A (pt) |
CA (2) | CA2480410A1 (pt) |
MX (2) | MXPA04009831A (pt) |
WO (2) | WO2003087108A2 (pt) |
Families Citing this family (10)
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WO2005068420A1 (en) * | 2003-12-23 | 2005-07-28 | Esperion Therapeutics, Inc. | Urea and thiourea compounds and compositions for cholesterol management and related uses |
GB0425787D0 (en) * | 2004-11-24 | 2004-12-22 | Univ Nottingham | Modulation of blood clotting |
NZ561375A (en) | 2005-06-27 | 2011-06-30 | Biovail Lab Int Srl | Bupropion hydrobromide, and crystalline forms, compositions, and uses of this compound |
JP2010163425A (ja) * | 2008-12-18 | 2010-07-29 | Daiichi Sankyo Healthcare Co Ltd | ホスホジエステラーゼ5阻害剤とパンテチンを含有する医薬組成物 |
EP3215496B1 (en) | 2014-11-06 | 2019-01-02 | Radboud Universitair Medisch Centrum | Pantothenamide analogues |
CN108841785A (zh) * | 2018-06-15 | 2018-11-20 | 广州赛莱拉干细胞科技股份有限公司 | 脂肪组织消化液和快速获得基质血管成分细胞的方法 |
FR3094208B1 (fr) | 2019-04-01 | 2021-02-26 | Gelnesis | composition pharmaceutique contenant de l’éthanol et un antibiotique et apte à former une masse solide au contact avec une solution saline - produit et dispositif de concentration et relargage de proximité associés |
CN114126593B (zh) | 2019-07-26 | 2024-07-26 | 埃斯佩尔维塔治疗股份有限公司 | 可用于预防或治疗疾病的官能化的长链烃一元和二元羧酸 |
WO2022159808A2 (en) | 2021-01-25 | 2022-07-28 | Espervita Therapeutics, Inc. | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease |
TW202245804A (zh) | 2021-01-25 | 2022-12-01 | 美商艾斯佩維他治療學公司 | 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途 |
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US2411611A (en) * | 1941-05-20 | 1946-11-26 | Hoffmann La Roche | Manufacture of nu-(polyhydroxyalkyl)-arylamines |
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FR1844M (fr) * | 1962-05-07 | 1963-06-04 | Solucal | Pantothénate de bismuthyle. |
US3287419A (en) * | 1962-08-16 | 1966-11-22 | Eastman Kodak Co | 3, 3'-oxybis |
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FR1414974A (fr) * | 1963-10-09 | 1965-10-22 | Hoffmann La Roche | éther nouveau, notamment éther 3, 3'-bis-(alpha, gamma-dihydroxy-beta, beta-diméthyl-butyrylamino)-dipropylique |
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US3520932A (en) * | 1968-02-05 | 1970-07-21 | Eastman Kodak Co | Preparation of 5-amino-2,2-dialkylpentanols |
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JPS5639033A (en) * | 1979-09-04 | 1981-04-14 | Kao Corp | Alpha-mono(methyl-branched alkyl glyceryl ether and skin cosmetic containing the same |
IL64542A0 (en) * | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
EP0129031A3 (en) * | 1983-05-19 | 1985-10-09 | Suntory Limited | Antimutagenic agent |
IT1164254B (it) * | 1983-05-30 | 1987-04-08 | Luso Farmaco Inst | 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione |
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CA2425311C (en) * | 2000-10-11 | 2011-06-14 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
CN1479721A (zh) * | 2000-10-11 | 2004-03-03 | ͨ��ҽ�ƹ�˾ | 用于胆固醇治疗和相关应用的亚砜和双亚砜化合物和组合物 |
CN101426763A (zh) * | 2000-10-11 | 2009-05-06 | 埃斯佩里安医疗公司 | 用于胆固醇治疗和相关应用的硫化物和二硫化物化合物和组合物 |
-
2003
- 2003-04-10 US US10/410,262 patent/US20030236212A1/en not_active Abandoned
- 2003-04-10 JP JP2003584064A patent/JP2005522509A/ja active Pending
- 2003-04-10 WO PCT/US2003/011467 patent/WO2003087108A2/en not_active Application Discontinuation
- 2003-04-10 EP EP03718387A patent/EP1495034A2/en not_active Withdrawn
- 2003-04-10 AU AU2003230918A patent/AU2003230918A1/en not_active Abandoned
- 2003-04-10 MX MXPA04009831A patent/MXPA04009831A/es unknown
- 2003-04-10 CA CA002480410A patent/CA2480410A1/en not_active Abandoned
- 2003-04-10 JP JP2003583996A patent/JP2005522504A/ja active Pending
- 2003-04-10 CA CA002480415A patent/CA2480415A1/en not_active Abandoned
- 2003-04-10 US US10/410,444 patent/US20030236213A1/en not_active Abandoned
- 2003-04-10 BR BRPI0309152-0A patent/BR0309152A/pt unknown
- 2003-04-10 WO PCT/US2003/011468 patent/WO2003087040A2/en not_active Application Discontinuation
- 2003-04-10 EP EP03724025A patent/EP1497247A2/en not_active Withdrawn
- 2003-04-10 AU AU2003221926A patent/AU2003221926A1/en not_active Abandoned
- 2003-04-10 MX MXPA04009832A patent/MXPA04009832A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003230918A1 (en) | 2003-10-27 |
AU2003230918A8 (en) | 2003-10-27 |
JP2005522509A (ja) | 2005-07-28 |
WO2003087040A2 (en) | 2003-10-23 |
AU2003221926A1 (en) | 2003-10-27 |
CA2480410A1 (en) | 2003-10-23 |
WO2003087108A3 (en) | 2004-07-15 |
JP2005522504A (ja) | 2005-07-28 |
MXPA04009831A (es) | 2004-12-07 |
US20030236213A1 (en) | 2003-12-25 |
WO2003087040A3 (en) | 2004-07-15 |
AU2003221926A8 (en) | 2003-10-27 |
WO2003087108A2 (en) | 2003-10-23 |
CA2480415A1 (en) | 2003-10-23 |
US20030236212A1 (en) | 2003-12-25 |
EP1497247A2 (en) | 2005-01-19 |
EP1495034A2 (en) | 2005-01-12 |
MXPA04009832A (es) | 2004-12-07 |
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