BR0212366A - Método e composição para tratar distúrbios associados com o complexo imune - Google Patents
Método e composição para tratar distúrbios associados com o complexo imuneInfo
- Publication number
- BR0212366A BR0212366A BR0212366-5A BR0212366A BR0212366A BR 0212366 A BR0212366 A BR 0212366A BR 0212366 A BR0212366 A BR 0212366A BR 0212366 A BR0212366 A BR 0212366A
- Authority
- BR
- Brazil
- Prior art keywords
- tlr
- immune complex
- icad
- immune
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Rehabilitation Therapy (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
"MéTODO E COMPOSIçãO PARA TRATAR DISTúRBIOS ASSOCIADOS COM COMPLEXO IMUNE". A presente invenção fornece métodos e composições para tratar doenças associadas com complexo imune (ICAD), tal como SLE, artrite reumatóide, e doenças do complexo imune relacionadas com hepatite c (por exemplo, crioglobulinemia) em um indivíduo tendo um ICAD ou em risco de desenvolver ICAD. A invenção é com base na surpreendente descoberta de que os complexos imune contendo cromatina ativam as células B e auto-reativas e dendríticas por um processo de comprometimento do receptor dual que, em ambos tipos de células, envolve um receptor tipo Toll (TLR). Os métodos de tratamento de ICAD compreendem administrar um composto à um indivíduo em necessidade deste que ou 1) inibe a formação do complexo imune ou por prevenção da formação e/ou aglutinação ao TLR, ou 2) interfere com a aglutinação de um complexo imune contendo auto-antígeno (ou o componente antigênico deste) ao TLR, ou 3) inibe as vias de sinalização iniciadas pelo comprometimento dual de BCR e TLR (nas células B) ou FcR e TLR (nas células dendríticas) através de auto-antígenos não complexos ou complexos imunes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31809601P | 2001-09-07 | 2001-09-07 | |
US36757802P | 2002-03-26 | 2002-03-26 | |
PCT/US2002/028708 WO2003022296A1 (en) | 2001-09-07 | 2002-09-09 | Method and composition for treating immune complex associated disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212366A true BR0212366A (pt) | 2004-07-27 |
Family
ID=26981316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212366-5A BR0212366A (pt) | 2001-09-07 | 2002-09-09 | Método e composição para tratar distúrbios associados com o complexo imune |
Country Status (12)
Country | Link |
---|---|
US (2) | US7709451B2 (pt) |
EP (1) | EP1435987A4 (pt) |
JP (2) | JP2005501917A (pt) |
KR (1) | KR20040053122A (pt) |
CN (1) | CN1575184A (pt) |
AU (1) | AU2002324937B2 (pt) |
BR (1) | BR0212366A (pt) |
CA (1) | CA2459310A1 (pt) |
EA (1) | EA200400407A1 (pt) |
IL (1) | IL160561A0 (pt) |
NZ (1) | NZ531612A (pt) |
WO (1) | WO2003022296A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4280309B2 (ja) * | 1997-06-06 | 2009-06-17 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | Dna免疫刺激配列活性の阻害剤 |
US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
WO2006047954A1 (fr) * | 2004-11-04 | 2006-05-11 | Ziyi Cheng | Procédé d'obtention et d'application des matières pour la reconnaissance immunologique d'autoantigènes |
AR051836A1 (es) * | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
ES2348792T3 (es) * | 2004-12-10 | 2010-12-14 | Novimmune Sa | TERAPIAS COMBINADAS DIRIGIDAS A MÚLTIPLES RECEPTORES TIPO TOLL Y USO DE LAS MISMAS. |
CN100429233C (zh) * | 2005-02-03 | 2008-10-29 | 上海长海医院 | 一种重组融合蛋白及其制备方法及用途 |
JP5199878B2 (ja) * | 2005-10-27 | 2013-05-15 | セントカー・インコーポレーテツド | Toll様受容体3モジュレーター、方法および用途 |
JP2010509398A (ja) * | 2006-11-15 | 2010-03-25 | ザ テキサス エー アンド エム ユニバーシティ システム | Toll様受容体3に関連する組成物および方法 |
US8323656B2 (en) * | 2007-06-25 | 2012-12-04 | Yijun Xu | Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof |
JP2013506687A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー促進遺伝子産物の変調によりオートファジーを変調する方法 |
EP2492689B8 (en) | 2011-02-22 | 2013-12-25 | Bernhard-Nocht-Institut für Tropenmedizin | Detection of antibodies using an improved immune complex (IC) ELISA |
WO2013169382A1 (en) * | 2012-05-07 | 2013-11-14 | DePuy Synthes Products, LLC | Methods and devices for treating intervertebral disc disease |
EP2893041A4 (en) * | 2012-09-05 | 2016-07-06 | Bio Rad Laboratories | CHIMERIC ANTI-DSDNA / CHROMATIN ANTIBODY |
US10881720B2 (en) | 2014-01-30 | 2021-01-05 | The Board Of Regents Of The University Of Texas System | Nanoparticles for immune stimulation |
CN109712678B (zh) * | 2018-12-12 | 2020-03-06 | 中国人民解放军军事科学院军事医学研究院 | 关系预测方法、装置及电子设备 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0559046A (ja) * | 1991-06-26 | 1993-03-09 | Ajinomoto Co Inc | 免疫調節剤 |
ATE328890T1 (de) * | 1994-07-15 | 2006-06-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
JP3472048B2 (ja) * | 1995-10-09 | 2003-12-02 | 鐘淵化学工業株式会社 | 自己免疫疾患の診断薬 |
AU738513B2 (en) * | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
AU7690898A (en) * | 1997-05-20 | 1998-12-11 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
WO1999001154A1 (en) | 1997-07-03 | 1999-01-14 | University Of Iowa Research Foundation | Method for inhibiting immunostimulatory dna associated responses |
DE69935507T2 (de) * | 1998-04-03 | 2007-12-06 | University Of Iowa Research Foundation | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
EP1820514A3 (en) * | 1998-06-15 | 2007-10-17 | AltaRex Medical Corporation | Therapeutic compositions that produce an immune response by altering the antigen |
SK287400B6 (sk) | 1999-09-25 | 2010-08-09 | University Of Iowa Research Foundation | Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie |
DE10083095D2 (de) * | 1999-10-12 | 2002-01-31 | Fritz Schwarzmann | Gentransfervektoren zur Therapie von Autoimmunerkrankungen und Erkrankungen mit Immunpathogenese |
GB9927332D0 (en) * | 1999-11-18 | 2000-01-12 | Leiv Eiriksson Nyfotek As | Novel antibody and uses thereof |
US20040023870A1 (en) * | 2000-01-21 | 2004-02-05 | Douglas Dedera | Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins |
GB0001704D0 (en) * | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
JP5004261B2 (ja) * | 2000-05-19 | 2012-08-22 | コリクサ コーポレイション | 単糖類及び二糖類に基づく化合物を用いた感染症及び他の疾患の予防的並びに治療的な処置 |
EP1296714B1 (en) * | 2000-06-22 | 2009-08-26 | University Of Iowa Research Foundation | Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer. |
CA2432542A1 (en) | 2000-12-22 | 2002-07-04 | Synovis Limited | Methods of modulating toll-related receptor (trr) signaling |
EP1412390A2 (en) | 2001-07-26 | 2004-04-28 | Tanox, Inc. | Agents that activate or inhibit toll-like receptor 9 |
-
2002
- 2002-09-09 NZ NZ531612A patent/NZ531612A/en not_active IP Right Cessation
- 2002-09-09 CN CNA028175123A patent/CN1575184A/zh active Pending
- 2002-09-09 IL IL16056102A patent/IL160561A0/xx unknown
- 2002-09-09 US US10/487,885 patent/US7709451B2/en not_active Expired - Fee Related
- 2002-09-09 JP JP2003526424A patent/JP2005501917A/ja not_active Ceased
- 2002-09-09 EP EP02759611A patent/EP1435987A4/en not_active Ceased
- 2002-09-09 WO PCT/US2002/028708 patent/WO2003022296A1/en active IP Right Grant
- 2002-09-09 EA EA200400407A patent/EA200400407A1/ru unknown
- 2002-09-09 BR BR0212366-5A patent/BR0212366A/pt not_active Application Discontinuation
- 2002-09-09 AU AU2002324937A patent/AU2002324937B2/en not_active Ceased
- 2002-09-09 CA CA002459310A patent/CA2459310A1/en not_active Abandoned
- 2002-09-09 KR KR10-2004-7003342A patent/KR20040053122A/ko not_active Application Discontinuation
-
2009
- 2009-06-17 JP JP2009144762A patent/JP2009203245A/ja not_active Withdrawn
- 2009-11-25 US US12/625,815 patent/US20100203053A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1435987A4 (en) | 2005-11-23 |
EP1435987A1 (en) | 2004-07-14 |
CA2459310A1 (en) | 2003-03-20 |
EA200400407A1 (ru) | 2004-08-26 |
WO2003022296A1 (en) | 2003-03-20 |
US20100203053A1 (en) | 2010-08-12 |
KR20040053122A (ko) | 2004-06-23 |
IL160561A0 (en) | 2004-07-25 |
CN1575184A (zh) | 2005-02-02 |
US7709451B2 (en) | 2010-05-04 |
US20050106142A1 (en) | 2005-05-19 |
NZ531612A (en) | 2006-01-27 |
JP2009203245A (ja) | 2009-09-10 |
AU2002324937B2 (en) | 2008-11-13 |
JP2005501917A (ja) | 2005-01-20 |
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