BR0209974A - Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm - Google Patents

Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm

Info

Publication number
BR0209974A
BR0209974A BR0209974-8A BR0209974A BR0209974A BR 0209974 A BR0209974 A BR 0209974A BR 0209974 A BR0209974 A BR 0209974A BR 0209974 A BR0209974 A BR 0209974A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
preparation process
compositions containing
quinoline derivatives
tricyclic
Prior art date
Application number
BR0209974-8A
Other languages
English (en)
Inventor
Henri-Philippe Husson
Sylviane Giorgi-Renault
Stephanie Desbene
John Hickman
Alain Pierre
Laurence Kraus-Berthier
Bruno Pfeiffer
Pierre Renard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0209974A publication Critical patent/BR0209974A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"DERIVADOS TRICìCLICOS DE DIHIDRO-QUINOLEìNAS, O RESPECTIVO PROCESSO DE PREPARAçãO E AS COMPOSIçõES FARMACêUTICAS QUE OS CONTêM". A invenção refere-se a um composto de fórmula (I), na qual: (a) representa uma ligação simples ou dupla; -(b) representa um ciclo escolhido dentre (I), (II), (III), (IV), (V), (VI) e (VII). Os compostos da invenção, além do fato de serem novos, apresentam propriedades antitumorais muito interessantes.
BR0209974-8A 2001-05-23 2002-05-22 Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm BR0209974A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0106792A FR2825091B1 (fr) 2001-05-23 2001-05-23 Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2002/001715 WO2002094835A1 (fr) 2001-05-23 2002-05-22 Nouveaux derives tricycliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0209974A true BR0209974A (pt) 2004-04-06

Family

ID=8863589

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209974-8A BR0209974A (pt) 2001-05-23 2002-05-22 Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm

Country Status (18)

Country Link
US (1) US20040198981A1 (pt)
EP (1) EP1389210A1 (pt)
JP (1) JP2004535405A (pt)
KR (1) KR20030097898A (pt)
CN (1) CN1511158A (pt)
AR (1) AR033915A1 (pt)
BR (1) BR0209974A (pt)
CA (1) CA2448191A1 (pt)
CZ (1) CZ20033495A3 (pt)
EA (1) EA200301171A1 (pt)
FR (1) FR2825091B1 (pt)
HU (1) HUP0400436A2 (pt)
MX (1) MXPA03010599A (pt)
NO (1) NO20035215L (pt)
PL (1) PL364082A1 (pt)
SK (1) SK16022003A3 (pt)
WO (1) WO2002094835A1 (pt)
ZA (1) ZA200308629B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE455115T1 (de) * 2005-07-20 2010-01-15 Aventis Pharma Sa 1,4-dihydropyridine-kondensierte heterocyclen verfahren zu deren herstellung sowie verwendung und zusammensetzungen dergleichen
WO2012076942A1 (en) * 2010-12-06 2012-06-14 Council Of Scientific & Industrial Research 4-aza-2, 3-didehydropodophyllotoxin compounds and process for the preparation thereof
AU2015205995A1 (en) 2014-01-15 2016-07-28 Centre National De La Recherche Scientifique (Cnrs) Water soluble 4-azapodophyllotoxin analogs
WO2017151947A1 (en) * 2016-03-02 2017-09-08 George Robert Pettit 4-azapodophylotoxins compounds
CN111494374B (zh) * 2020-06-12 2021-08-03 广东省微生物研究所（广东省微生物分析检测中心） 香草木宁碱在制备破骨细胞分化抑制剂中的应用
CN114989180B (zh) * 2022-05-26 2024-06-04 广东海洋大学 杨叶肖槿内生真菌来源的化合物及其制备方法与应用
WO2024015793A2 (en) * 2022-07-12 2024-01-18 Oregon Health & Science University Enantiomer of azopodophyllotoxin derivative su056
US11731980B1 (en) 2023-03-22 2023-08-22 King Faisal University Furo[3,4-b]quinolone compounds as antibacterial agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801310B1 (fr) * 1999-11-24 2004-04-16 Adir NOUVEAUX DERIVES DE DIHYDROFURO-[3,4-b]QUINOLEIN-1-ONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT

Also Published As

Publication number Publication date
WO2002094835A1 (fr) 2002-11-28
SK16022003A3 (sk) 2004-05-04
CN1511158A (zh) 2004-07-07
US20040198981A1 (en) 2004-10-07
ZA200308629B (en) 2004-11-05
MXPA03010599A (es) 2004-03-09
NO20035215D0 (no) 2003-11-24
JP2004535405A (ja) 2004-11-25
FR2825091B1 (fr) 2003-07-04
KR20030097898A (ko) 2003-12-31
EP1389210A1 (fr) 2004-02-18
FR2825091A1 (fr) 2002-11-29
AR033915A1 (es) 2004-01-07
EA200301171A1 (ru) 2004-04-29
HUP0400436A2 (hu) 2004-09-28
CZ20033495A3 (en) 2004-05-12
NO20035215L (no) 2003-11-24
CA2448191A1 (fr) 2002-11-28
PL364082A1 (en) 2004-12-13

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]