BR0209943A - Desenvolvimento de mutações úteis para atenuar vìrus da dengue e vìrus da dengue quiméricos - Google Patents

Desenvolvimento de mutações úteis para atenuar vìrus da dengue e vìrus da dengue quiméricos

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Publication number
BR0209943A
BR0209943A BR0209943-8A BRPI0209943A BR0209943A BR 0209943 A BR0209943 A BR 0209943A BR PI0209943 A BRPI0209943 A BR PI0209943A BR 0209943 A BR0209943 A BR 0209943A
Authority
BR
Brazil
Prior art keywords
dengue virus
development
attenuate
chimeric
useful mutations
Prior art date
Application number
BR0209943-8A
Other languages
English (en)
Inventor
Stephen S Whitehead
Brian R Murphy
Kathryn A Hanley
Original Assignee
Us Health
Joseph E Blaney Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Joseph E Blaney Jr filed Critical Us Health
Priority to BR122019026154A priority Critical patent/BR122019026154B8/pt
Publication of BR0209943A publication Critical patent/BR0209943A/pt
Publication of BRPI0209943B1 publication Critical patent/BRPI0209943B1/pt
Publication of BRPI0209943B8 publication Critical patent/BRPI0209943B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
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    • A61K2039/70—Multivalent vaccine
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    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/24011—Flaviviridae
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C12N2770/24163—Methods of inactivation or attenuation by chemical treatment
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24171—Demonstrated in vivo effect
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

"DESENVOLVIMENTO DE MUTAçõES úTEIS PARA ATENUAR VìRUS DA DENGUE E VìRUS DA DENGUE QUIMéRICOS". A presente invenção refere-se ao desenvolvimento de um menu de mutações que é útil na afinação da atenuação de características de crescimento das vacinas de vírus da dengue.
BRPI0209943-8 2001-05-22 2002-05-22 desenvolvimento de mutações úteis para atenuar vírus da dengue e vírus da dengue quiméricos BRPI0209943B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122019026154A BR122019026154B8 (pt) 2001-05-22 2002-05-22 vírus da dengue atenuado, composições farmacêuticas compreendendo dito vírus, kit, vacinas tetravalente, atenuada viva e inativada contra o vírus da dengue, e métodos para preparar um vírus da dengue e uma composição farmacêutica

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29304901P 2001-05-22 2001-05-22
US60/293,049 2001-05-22
PCT/US2002/016308 WO2002095075A1 (en) 2001-05-22 2002-05-22 Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

Publications (3)

Publication Number Publication Date
BR0209943A true BR0209943A (pt) 2004-03-30
BRPI0209943B1 BRPI0209943B1 (pt) 2020-10-13
BRPI0209943B8 BRPI0209943B8 (pt) 2021-05-25

Family

ID=23127420

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0209943-8 BRPI0209943B8 (pt) 2001-05-22 2002-05-22 desenvolvimento de mutações úteis para atenuar vírus da dengue e vírus da dengue quiméricos
BR122019026154A BR122019026154B8 (pt) 2001-05-22 2002-05-22 vírus da dengue atenuado, composições farmacêuticas compreendendo dito vírus, kit, vacinas tetravalente, atenuada viva e inativada contra o vírus da dengue, e métodos para preparar um vírus da dengue e uma composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122019026154A BR122019026154B8 (pt) 2001-05-22 2002-05-22 vírus da dengue atenuado, composições farmacêuticas compreendendo dito vírus, kit, vacinas tetravalente, atenuada viva e inativada contra o vírus da dengue, e métodos para preparar um vírus da dengue e uma composição farmacêutica

Country Status (8)

Country Link
US (10) US7226602B2 (pt)
EP (5) EP2940154B1 (pt)
AU (2) AU2002312011B2 (pt)
BR (2) BRPI0209943B8 (pt)
CA (5) CA3060687C (pt)
DK (4) DK1402075T3 (pt)
ES (4) ES2523168T3 (pt)
WO (1) WO2002095075A1 (pt)

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BR112018071176A2 (pt) 2016-04-14 2019-02-12 National University Of Singapore método rápido de produção de vacinas vivas atenuadas
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US20050010043A1 (en) 2005-01-13
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