BR0117087A - Oligopeptìdeos de desenvolvimento osteogênico como estimulantes de hematopoese - Google Patents

Oligopeptìdeos de desenvolvimento osteogênico como estimulantes de hematopoese

Info

Publication number
BR0117087A
BR0117087A BR0117087-2A BR0117087A BR0117087A BR 0117087 A BR0117087 A BR 0117087A BR 0117087 A BR0117087 A BR 0117087A BR 0117087 A BR0117087 A BR 0117087A
Authority
BR
Brazil
Prior art keywords
gly
oligopeptides
phe
tyr
bone marrow
Prior art date
Application number
BR0117087-2A
Other languages
English (en)
Inventor
Itai Bab
Michael Chorev
Arye SHTEYER
Andras Muhlrad
Nura Mansur
Olga Gurevitch
Zvi Greenberg
Sergio Rosini
Silvia Trasciatti
Mario PETRINI
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Publication of BR0117087A publication Critical patent/BR0117087A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Abstract

"OLIGOPEPTìDEOS DE DESENVOLVIMENTO OSTEOGêNICO COMO ESTIMULANTES DE HEMATOPOESE". A presente invenção refere-se a uma composição farmacêutica compreendendo como um ingrediente eficaz um oligopeptídeo idêntico ou análogo à porção de C-terminal de OGP, tendo atividade enxaguadora na produção de células hematopóeticas. Oligopeptídeos preferidos que são usados são Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly e Met-Tyr-Gly-Phe-Gly-Gly. Mais especificamente, estes oligopeptídeos realçam o enxerto de transplantes de medula óssea, reconstrução hemopoiética, repopulação da medula óssea e mobilização de célula tronco periférica, preferivelmente depois da quimioterapia ou irradiação. A invenção também fornece métodos de tratamento e para usar estes oligopeptídeos na preparação de composições farmacêuticas.
BR0117087-2A 2001-07-29 2001-07-29 Oligopeptìdeos de desenvolvimento osteogênico como estimulantes de hematopoese BR0117087A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2001/000700 WO2003011313A1 (en) 2001-07-29 2001-07-29 Osteogenic growth oligopeptides as stimulants of hematopoiesis

Publications (1)

Publication Number Publication Date
BR0117087A true BR0117087A (pt) 2004-08-03

Family

ID=11043077

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0117087-2A BR0117087A (pt) 2001-07-29 2001-07-29 Oligopeptìdeos de desenvolvimento osteogênico como estimulantes de hematopoese

Country Status (19)

Country Link
US (1) US20050004037A1 (pt)
EP (1) EP1414480A1 (pt)
JP (1) JP2004536876A (pt)
KR (1) KR20040044436A (pt)
CN (1) CN1310672C (pt)
AU (1) AU2001282436B8 (pt)
BR (1) BR0117087A (pt)
CA (1) CA2456092A1 (pt)
CZ (1) CZ2004300A3 (pt)
EE (1) EE200400062A (pt)
HR (1) HRP20040135A2 (pt)
HU (1) HUP0400667A2 (pt)
IL (1) IL160016A0 (pt)
IS (1) IS7129A (pt)
MX (1) MXPA04000858A (pt)
NO (1) NO20040378L (pt)
NZ (1) NZ530904A (pt)
SK (1) SK912004A3 (pt)
WO (1) WO2003011313A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532261A (zh) * 2010-12-29 2012-07-04 中国医学科学院药物研究所 骨重建激活剂-酪脯肽及其药物组合物和用途
CN106726672A (zh) * 2016-12-29 2017-05-31 陕西慧康生物科技有限责任公司 一种化妆品组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5461034A (en) * 1989-02-23 1995-10-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Osteogenic growth polypeptides identified from regenerating bone marrow
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5154921A (en) * 1990-07-13 1992-10-13 Dana-Farber Cancer Institute, Inc. Promotion of maturation of hematopoietic progenitor cells
DE4240635C2 (de) * 1992-12-03 1997-07-10 Lothar Prof Dr Kanz Vermehrung hämatopoetischer Vorläuferzellen ex vivo sowieZusammensetzungen hämatopoetischer Wachstumsfaktoren
IL104954A (en) * 1993-03-04 2006-08-01 Yissum Res Dev Co Use of osteogenic oligopeptides in the preparation of pharmaceutical compositions for the treatment of bone diseases and some such novel oligopeptides, pharmaceutical compositions containing them and their preparation
EP0721780A3 (en) * 1994-12-16 1997-12-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Agent for promoting platelet and/or leukocyte production
CN1163262C (zh) * 1999-04-01 2004-08-25 上海益众生物技术有限公司 成骨生长肽药物组合物及制备方法和应用

Also Published As

Publication number Publication date
US20050004037A1 (en) 2005-01-06
KR20040044436A (ko) 2004-05-28
NO20040378L (no) 2004-03-26
WO2003011313A8 (en) 2004-04-08
HUP0400667A2 (hu) 2004-12-28
CN1551779A (zh) 2004-12-01
CA2456092A1 (en) 2003-02-13
NZ530904A (en) 2005-09-30
HRP20040135A2 (en) 2005-02-28
CN1310672C (zh) 2007-04-18
MXPA04000858A (es) 2005-06-06
IL160016A0 (en) 2004-06-20
AU2001282436B2 (en) 2008-03-06
EP1414480A1 (en) 2004-05-06
EE200400062A (et) 2004-06-15
CZ2004300A3 (cs) 2005-03-16
AU2001282436B8 (en) 2008-05-01
WO2003011313A1 (en) 2003-02-13
IS7129A (is) 2004-01-28
JP2004536876A (ja) 2004-12-09
SK912004A3 (en) 2004-07-07

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 8A, 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.

B15K Others concerning applications: alteration of classification

Free format text: PROCEDIMENTO AUTOMATICO DE RECLASSIFICACAO. AS CLASSIFICACOES IPC ANTERIORES ERAM: A61K 38/07; A61K 38/08; A61P 7/00; A61P 35/02; A61P 37/00; C12N 5/00; C12N 5/08.

Ipc: A61K 38/08 (2006.01), A61K 38/07 (2006.01), C12N 5

Ipc: A61K 38/08 (2006.01), A61K 38/07 (2006.01), C12N 5