BR0114689A - Composto, composição farmacêutica, processo para a produção de uma composição farmacêutica, métodos para eliciar um efeito de modulação de receptor de estrogênio em um mamìfero, para o tratamento ou prevenção de, osteporose, pósmenopausa em um indivìduo do sexo feminino, e para o tratamento ou prevenção de um distúrbio - Google Patents
Composto, composição farmacêutica, processo para a produção de uma composição farmacêutica, métodos para eliciar um efeito de modulação de receptor de estrogênio em um mamìfero, para o tratamento ou prevenção de, osteporose, pósmenopausa em um indivìduo do sexo feminino, e para o tratamento ou prevenção de um distúrbioInfo
- Publication number
- BR0114689A BR0114689A BR0114689-0A BR0114689A BR0114689A BR 0114689 A BR0114689 A BR 0114689A BR 0114689 A BR0114689 A BR 0114689A BR 0114689 A BR0114689 A BR 0114689A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- female
- prevention
- treatment
- estrogen receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A PRODUçãO DE UMA COMPOSIçãO FARMACêUTICA, MéTODOS PARA ELICIAR UM EFEITO DE MODULAçãO DE RECEPTOR DE ESTROGêNIO EM UM MAMìFERO, PARA O TRATAMENTO OU PREVENçãO DE OSTEPOROSE PóS-MENOPAUSA EM UM INDIVìDUO DO SEXO FEMININO, E PARA O TRATAMENTO OU PREVENçãO DE UM DISTúRBIO". A presente invenção refere-se a compostos e derivados dos mesmos, à sua síntese, e a seu uso como moduladores de receptor de estrogênio. Os compostos da presente invenção são ligantes para receptores de estrogênio e como tais podem ser úteis para o tratamento ou a prevenção de uma variedade de condições relacionadas ao funcionamento de estrogênio incluindo: perda óssea, fraturas ósseas, osteoporose, degeneração de cartilagem, endometriose, doença fibróide uterina, queimações, níveis aumentados de LD1, colesterol, doença cardiovascular, dano do funcionamento cognitivo, distúrbios degenerativos cerebrais, restenose, ginecomastia, proliferação da célula do músculo liso vascular, obesidade, incontinência, e câncer, em particular da mama, útero e próstata.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24158200P | 2000-10-19 | 2000-10-19 | |
| PCT/US2001/042735 WO2002032377A2 (en) | 2000-10-19 | 2001-10-15 | Estrogen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0114689A true BR0114689A (pt) | 2003-07-01 |
Family
ID=22911282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0114689-0A BR0114689A (pt) | 2000-10-19 | 2001-10-15 | Composto, composição farmacêutica, processo para a produção de uma composição farmacêutica, métodos para eliciar um efeito de modulação de receptor de estrogênio em um mamìfero, para o tratamento ou prevenção de, osteporose, pósmenopausa em um indivìduo do sexo feminino, e para o tratamento ou prevenção de um distúrbio |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1333827A2 (pt) |
| JP (1) | JP2004511502A (pt) |
| KR (1) | KR20030042020A (pt) |
| CN (1) | CN1469743A (pt) |
| AU (2) | AU2002232381B2 (pt) |
| BG (1) | BG107676A (pt) |
| BR (1) | BR0114689A (pt) |
| CA (1) | CA2424729A1 (pt) |
| EA (1) | EA200300474A1 (pt) |
| EC (1) | ECSP034558A (pt) |
| EE (1) | EE200300153A (pt) |
| HU (1) | HUP0303563A2 (pt) |
| IL (1) | IL154984A0 (pt) |
| IS (1) | IS6761A (pt) |
| MX (1) | MXPA03003485A (pt) |
| NO (1) | NO20031737L (pt) |
| PE (1) | PE20021083A1 (pt) |
| PL (1) | PL361053A1 (pt) |
| SK (1) | SK4772003A3 (pt) |
| WO (1) | WO2002032377A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030225132A1 (en) * | 2002-04-11 | 2003-12-04 | Dininno Frank P. | Estrogen receptor modulators |
| ES2350446T3 (es) * | 2002-04-24 | 2011-01-24 | MERCK SHARP & DOHME CORP. | Moduladores de los receptores de estrógenos. |
| JP4500689B2 (ja) * | 2002-12-26 | 2010-07-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的エストロゲン受容体モジュレーター |
| AU2006275514B2 (en) * | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| WO2007049798A1 (ja) | 2005-10-27 | 2007-05-03 | Banyu Pharmaceutical Co., Ltd. | 新規ベンゾオキサチイン誘導体 |
| US8053440B2 (en) | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
| EP2382194B1 (en) | 2009-01-08 | 2014-03-12 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| JP5795304B2 (ja) | 2009-03-18 | 2015-10-14 | レスバーロジックス コーポレイション | 新規抗炎症剤 |
| KR101892987B1 (ko) | 2009-04-22 | 2018-08-30 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| EP2580210B1 (en) | 2010-06-10 | 2017-03-01 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| US8853423B2 (en) | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| DK2773354T3 (da) | 2011-11-01 | 2019-08-05 | Resverlogix Corp | Oralformuleringer med øjeblikkelig frigivelse for substituerede quinazolinoner |
| US9187460B2 (en) | 2011-12-14 | 2015-11-17 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| KR102662814B1 (ko) | 2015-03-13 | 2024-05-03 | 리스버로직스 코퍼레이션 | 보체 관련 질환을 치료하기 위한 조성물 및 치료 방법 |
-
2001
- 2001-10-15 KR KR10-2003-7005518A patent/KR20030042020A/ko not_active Application Discontinuation
- 2001-10-15 CN CNA018176720A patent/CN1469743A/zh active Pending
- 2001-10-15 BR BR0114689-0A patent/BR0114689A/pt not_active Application Discontinuation
- 2001-10-15 IL IL15498401A patent/IL154984A0/xx unknown
- 2001-10-15 PL PL01361053A patent/PL361053A1/xx not_active Application Discontinuation
- 2001-10-15 WO PCT/US2001/042735 patent/WO2002032377A2/en not_active Application Discontinuation
- 2001-10-15 HU HU0303563A patent/HUP0303563A2/hu unknown
- 2001-10-15 AU AU2002232381A patent/AU2002232381B2/en not_active Ceased
- 2001-10-15 CA CA002424729A patent/CA2424729A1/en not_active Abandoned
- 2001-10-15 EA EA200300474A patent/EA200300474A1/ru unknown
- 2001-10-15 JP JP2002535616A patent/JP2004511502A/ja not_active Withdrawn
- 2001-10-15 MX MXPA03003485A patent/MXPA03003485A/es unknown
- 2001-10-15 AU AU3238102A patent/AU3238102A/xx active Pending
- 2001-10-15 EE EEP200300153A patent/EE200300153A/xx unknown
- 2001-10-15 EP EP01987654A patent/EP1333827A2/en not_active Withdrawn
- 2001-10-15 SK SK477-2003A patent/SK4772003A3/sk unknown
-
2002
- 2002-04-15 PE PE2002000308A patent/PE20021083A1/es not_active Application Discontinuation
-
2003
- 2003-03-26 BG BG107676A patent/BG107676A/bg unknown
- 2003-03-27 IS IS6761A patent/IS6761A/is unknown
- 2003-04-15 NO NO20031737A patent/NO20031737L/no unknown
- 2003-04-17 EC EC2003004558A patent/ECSP034558A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20021083A1 (es) | 2002-12-16 |
| AU2002232381B2 (en) | 2004-11-18 |
| HUP0303563A2 (hu) | 2004-03-01 |
| CN1469743A (zh) | 2004-01-21 |
| PL361053A1 (en) | 2004-09-20 |
| MXPA03003485A (es) | 2003-07-14 |
| NO20031737L (no) | 2003-06-19 |
| IS6761A (is) | 2003-03-27 |
| ECSP034558A (es) | 2003-06-25 |
| EA200300474A1 (ru) | 2003-10-30 |
| WO2002032377A3 (en) | 2002-08-22 |
| CA2424729A1 (en) | 2002-04-25 |
| EP1333827A2 (en) | 2003-08-13 |
| JP2004511502A (ja) | 2004-04-15 |
| KR20030042020A (ko) | 2003-05-27 |
| EE200300153A (et) | 2003-06-16 |
| WO2002032377A2 (en) | 2002-04-25 |
| NO20031737D0 (no) | 2003-04-15 |
| BG107676A (bg) | 2003-11-28 |
| SK4772003A3 (en) | 2003-08-05 |
| AU3238102A (en) | 2002-04-29 |
| IL154984A0 (en) | 2003-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |