BR0113876A - Dispositivo de bioreator, e, método para cultivar células vivas - Google Patents

Dispositivo de bioreator, e, método para cultivar células vivas

Info

Publication number
BR0113876A
BR0113876A BR0113876-6A BR0113876A BR0113876A BR 0113876 A BR0113876 A BR 0113876A BR 0113876 A BR0113876 A BR 0113876A BR 0113876 A BR0113876 A BR 0113876A
Authority
BR
Brazil
Prior art keywords
cells
living cells
matrix
liquid
bioreactor device
Prior art date
Application number
BR0113876-6A
Other languages
English (en)
Other versions
BR0113876B1 (pt
Inventor
Schalk Van Der Merwe
Francis Sean Moolman
Robert Paul Bond
Adriaan Jacobus Van Wyk
Original Assignee
Csir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csir filed Critical Csir
Publication of BR0113876A publication Critical patent/BR0113876A/pt
Publication of BR0113876B1 publication Critical patent/BR0113876B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"DISPOSITIVO DE BIOREATOR, E, MéTODO PARA CULTIVAR CéLULAS VIVAS". A invenção provê um dispositivo de bioreator e um método de cultivar células vivas. O dispositivo inclui um elemento de recepção que contém uma matriz de material de espuma poroso em cujo interior células vivas são ancoradas, o dispositivo também incluindo um líquido contido no elemento de recepção. O líquido é um veículo de oxigênio e satura a matriz, o líquido incluindo um constituinte sintético ou semi-sintético. O método envolve perfundir o líquido veiculo de oxigênio pela matriz para entregar oxigênio às células e para absorver dióxido de carbono das células.
BRPI0113876-6B1A 2000-09-13 2001-08-27 Dispositivo de bioreator, e, método para cultivar células vivas BR0113876B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200004861 2000-09-13
PCT/IB2001/001549 WO2002022775A1 (en) 2000-09-13 2001-08-27 Bio-reactor device

Publications (2)

Publication Number Publication Date
BR0113876A true BR0113876A (pt) 2003-07-22
BR0113876B1 BR0113876B1 (pt) 2013-12-24

Family

ID=25588911

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0113876-6B1A BR0113876B1 (pt) 2000-09-13 2001-08-27 Dispositivo de bioreator, e, método para cultivar células vivas

Country Status (16)

Country Link
US (1) US7129082B2 (pt)
EP (1) EP1317526B1 (pt)
JP (1) JP2004508821A (pt)
KR (1) KR100803836B1 (pt)
CN (1) CN1312269C (pt)
AT (1) ATE396251T1 (pt)
AU (1) AU2001282382A1 (pt)
BR (1) BR0113876B1 (pt)
CA (1) CA2422230C (pt)
DE (1) DE60134157D1 (pt)
EA (1) EA004455B1 (pt)
ES (1) ES2305098T3 (pt)
FR (1) FR2814468B1 (pt)
IT (1) ITMI20011865A1 (pt)
NL (1) NL1018942C2 (pt)
WO (1) WO2002022775A1 (pt)

Families Citing this family (18)

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KR100441290B1 (ko) * 2002-08-14 2004-07-21 학교법인고려중앙학원 미생물을 고체배양하여 포자를 고농도로 생산할 수 있는충전층 생물반응기와 이를 이용한 고체배양방법
EP2659831B1 (en) * 2003-12-18 2016-11-30 Metronom Health, Inc. Stabilized oxygen transport matrix
DE102004039762A1 (de) * 2004-08-17 2006-03-02 Wilden Ag Substrat, Verfahren zu seiner Herstellung und Verwendung für die Bildung von Kulturen aus organischen Zellen
WO2010139337A1 (en) * 2009-06-03 2010-12-09 Aarhus Universitet Submerged perfusion bioreactor
CN102071137B (zh) * 2009-11-19 2014-10-22 上海坤巨科技发展有限公司 连续灌注生物反应器/罐袋系统制备干细胞装置和方法
CN102127505B (zh) * 2010-12-31 2013-04-17 浙江海洋学院 固定化细胞生物反应器
KR101880676B1 (ko) * 2011-08-22 2018-07-20 인제대학교 산학협력단 조혈모세포 또는 전구 세포의 체외 확대 성장을 위한 스캐폴드 어셈블리, 상기 스캐폴드 어셈블리를 이용하는 조혈모세포 또는 전구 세포의 체외 확대 성장을 위한 관류형 생물 반응기 및 생물 반응 시스템
CN102872478B (zh) * 2012-10-19 2014-11-26 陕西正凡科技发展有限公司 一种全生物化组织工程血管的构建方法
CN113549525A (zh) * 2014-11-04 2021-10-26 凸版印刷株式会社 核酸导入方法、核酸检测方法、生物体成分解析方法及试剂盒、生物体成分定量用阵列器件
CN105879135B (zh) * 2015-08-20 2018-10-16 河南大学 人工肝用扩张床载微胶囊反应器
MX2018002587A (es) 2015-09-02 2019-02-07 Metronom Health Inc Sistemas y métodos para control continuo de la salud utilizando un sensor de analitos optoenzimático.
CN105238735B (zh) * 2015-11-13 2019-02-26 广州洁特生物过滤股份有限公司 三维细胞培养支架及其制备方法
CN106139289B (zh) * 2016-07-29 2018-06-19 武汉仝干医疗科技股份有限公司 半透膜分层一体式生物反应器
DE102017213923A1 (de) * 2017-08-10 2019-02-14 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Vorrichtung zur Kultivierung von Gewebeschnitten
WO2019222847A1 (en) * 2018-05-22 2019-11-28 Morphocell Technologies Inc. Perfusion bioreactor, perfusion device, artificial liver system, and related methods
US20220081667A1 (en) * 2019-01-18 2022-03-17 Hewlett-Packard Development Company, L.P. Blood circulation for culture growth
CN110478548A (zh) * 2019-07-31 2019-11-22 南方医科大学珠江医院 生物人工肝系统
KR102353809B1 (ko) * 2019-12-31 2022-01-20 (주)아이벡스메디칼시스템즈 고압산소챔버 제어 시스템

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5669486A (en) * 1985-04-04 1986-10-23 Verax Corp. Weighted microsponge for immobilizing bioactive material
JPH0634699B2 (ja) * 1986-12-27 1994-05-11 千代田化工建設株式会社 動物細胞培養方法及び装置
US5262320A (en) * 1990-06-18 1993-11-16 Massachusetts Institute Of Technology Cell-culturing apparatus and method employing a macroporous support
GB9214379D0 (en) 1992-07-07 1992-08-19 Health Lab Service Board Process for culturing cells
AU6766994A (en) 1994-04-01 1995-10-23 Unisyn Technologies, Inc. Culture media additives for hollow fiber bioreactors
JPH1146759A (ja) * 1997-08-06 1999-02-23 Terumo Corp 細胞培養液
CN1115407C (zh) * 1998-11-05 2003-07-23 四川大学华西医院 复合场三维细胞培养装置
CA2375505A1 (en) * 1999-06-21 2000-12-28 The General Hospital Corporation Cell culture systems and methods for organ assist devices

Also Published As

Publication number Publication date
EA200300350A1 (ru) 2003-08-28
EA004455B1 (ru) 2004-04-29
FR2814468B1 (fr) 2003-12-05
CA2422230C (en) 2011-03-15
WO2002022775A1 (en) 2002-03-21
CN1455812A (zh) 2003-11-12
ITMI20011865A1 (it) 2003-03-05
US20030180942A1 (en) 2003-09-25
US7129082B2 (en) 2006-10-31
AU2001282382A1 (en) 2002-03-26
EP1317526A1 (en) 2003-06-11
DE60134157D1 (de) 2008-07-03
NL1018942A1 (nl) 2002-03-15
FR2814468A1 (fr) 2002-03-29
ITMI20011865A0 (it) 2001-09-05
JP2004508821A (ja) 2004-03-25
KR20030045053A (ko) 2003-06-09
EP1317526B1 (en) 2008-05-21
ES2305098T3 (es) 2008-11-01
NL1018942C2 (nl) 2002-07-02
KR100803836B1 (ko) 2008-02-14
BR0113876B1 (pt) 2013-12-24
CN1312269C (zh) 2007-04-25
CA2422230A1 (en) 2002-03-21
ATE396251T1 (de) 2008-06-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/12/2013, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2476 DE 19-06-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.