BR0111624A - Método aperfeiçoado para a sìntese de sacarose-6-ésteres - Google Patents

Método aperfeiçoado para a sìntese de sacarose-6-ésteres

Info

Publication number
BR0111624A
BR0111624A BR0111624-0A BR0111624A BR0111624A BR 0111624 A BR0111624 A BR 0111624A BR 0111624 A BR0111624 A BR 0111624A BR 0111624 A BR0111624 A BR 0111624A
Authority
BR
Brazil
Prior art keywords
reaction mixture
sucrose
water
distillation
ester
Prior art date
Application number
BR0111624-0A
Other languages
English (en)
Inventor
Jason D Clark
Jr Richard R Lemay
Original Assignee
Tate & Lyle Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tate & Lyle Plc filed Critical Tate & Lyle Plc
Publication of BR0111624A publication Critical patent/BR0111624A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"MéTODO APERFEIçOADO PARA A SìNTESE DE SACAROSE-6-éSTERES". Encontra-se descrito um processo para a síntese de um sacarose-6-éster compreendendo: a) reagir uma mistura compreendendo sacarose e um solvente polar aprótico com um promotor de acilação à base de organoestanho, ao mesmo tempo em que se adiciona um solvente capaz de remover a água por co-destilação, e remover a água por co-destilação para dar um primeira mistura reacional que é substancialmente isenta de água, seguido de (b) adicionar um anidrido carboxílico à referida primeira mistura reacional para dar uma segunda mistura reacional, e manter a referida segunda mistura reacional a uma temperatura e por um período de tempo suficientes para produzir um sacarose-6-éster, caracterizado pelo fato de a etapa (a) ser realizada a uma temperatura de 85 a 125<198>C e a uma pressão de 20 a 80 kPa. Na modalidade mais preferida, o solvente polar aprótico é DMF, o solvente capaz de remover água por co-destilação é ciclohexano, o promotor de acilação à base de organoestanho é um 1,3-diacilóxi-1,1,3,3-tetrabutildiestanoxano, e a etapa (a) é realizada a aproximadamente 97<198>C e aproximadamente 50 kPa, até que a razão em peso de estanho para água na primeira mistura reacional seja maior que cerca de 26, quando o teor de estanho é medido usando-se um analisador de fluorescência de raios-X, e o teor de água pode ser medido pelo método de Karl-Fischer.
BR0111624-0A 2000-07-31 2001-07-19 Método aperfeiçoado para a sìntese de sacarose-6-ésteres BR0111624A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0018784A GB2365424B (en) 2000-07-31 2000-07-31 An improved method for the synthesis of sucrose-6-esters
PCT/GB2001/003245 WO2002010180A1 (en) 2000-07-31 2001-07-19 An improved method for the synthesis of sucrose-6-esters

Publications (1)

Publication Number Publication Date
BR0111624A true BR0111624A (pt) 2003-05-06

Family

ID=9896697

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111624-0A BR0111624A (pt) 2000-07-31 2001-07-19 Método aperfeiçoado para a sìntese de sacarose-6-ésteres

Country Status (17)

Country Link
US (1) US6939962B2 (pt)
EP (1) EP1305326B1 (pt)
JP (1) JP4536321B2 (pt)
KR (2) KR20070094671A (pt)
CN (1) CN1210286C (pt)
AT (1) ATE292139T1 (pt)
AU (2) AU7087501A (pt)
BR (1) BR0111624A (pt)
CA (1) CA2417404C (pt)
DE (1) DE60109787T2 (pt)
ES (1) ES2239149T3 (pt)
GB (1) GB2365424B (pt)
IL (2) IL152599A0 (pt)
MX (1) MXPA03000986A (pt)
PT (1) PT1305326E (pt)
RU (2) RU2261252C2 (pt)
WO (1) WO2002010180A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1295237C (zh) * 2003-10-01 2007-01-17 常州市牛塘化工厂 蔗糖－6－乙酯溶液的制备方法
GB0702854D0 (en) * 2007-01-09 2007-03-28 Tate & Lyle Plc Method for the synthesis of sucrose-6-esters
CN101293902B (zh) * 2007-04-25 2011-05-11 吉安市新琪安科技有限公司 一种蔗糖-6-乙酯的合成方法
US20080300392A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
US20080300401A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
US20090076261A1 (en) * 2007-09-13 2009-03-19 Polymed Therapeutics, Inc. Novel process for preparing sucrose-6-esters
AR070082A1 (es) * 2008-01-04 2010-03-10 Tate & Lyle Technology Ltd Metodo para la produccion de sucralosa
WO2009117317A1 (en) * 2008-03-20 2009-09-24 Tate & Lyle Technology Ltd Removal of acids from tertiary amide solvents
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
WO2009124113A1 (en) * 2008-04-03 2009-10-08 Tate & Lyle Technology Ltd. Extraction of less polar impurities from sucralose containing aqueous feed streams
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
TW200946683A (en) * 2008-04-03 2009-11-16 Tate & Lyle Technology Ltd A process for the purification of aqueous feed streams containing sucralose extraction efficiency
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
GB2469157B (en) 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2469158B (en) * 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
GB2471348B (en) 2009-06-22 2011-12-14 Tate & Lyle Technology Ltd A method for producing sucralose-6-acylate
GB2474311B (en) 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
CN104098617A (zh) * 2013-04-08 2014-10-15 南京工业大学 一种蔗糖-6-乙酸酯的制备方法
CN105829332B (zh) 2013-12-16 2018-10-02 塔特和莱利技术有限公司 蔗糖-6-酯的氯化
WO2016020635A1 (en) 2014-08-08 2016-02-11 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
CN104817597A (zh) * 2015-05-22 2015-08-05 盐城捷康三氯蔗糖制造有限公司 蔗糖-6-酯的制备方法
CN105601665B (zh) * 2015-12-30 2018-07-17 浙江新和成股份有限公司 一种二丁基氧化锡的处理方法及其在蔗糖-6-乙酯合成中的应用
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
CN109438533A (zh) * 2018-12-10 2019-03-08 安徽金禾实业股份有限公司 一种三氯蔗糖生产中高温连续酰化的方法
CN112808048B (zh) * 2021-01-04 2022-05-31 安徽金禾实业股份有限公司 蔗糖-6-酯的制造设备及制造方法
EP4163000B1 (en) * 2021-02-19 2024-04-10 Anhui Jinhe Industrial Co., Ltd. Production apparatus and production method for sucrose-6-ester
CN112915565B (zh) * 2021-03-04 2022-04-08 安徽金禾实业股份有限公司 一种旋转式蔗糖-6-酯连续生产设备及生产方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0629198B2 (ja) * 1984-10-19 1994-04-20 武田薬品工業株式会社 化学的脱水反応方法
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
GR910100356A (el) * 1990-08-27 1992-08-31 Mcneil Ppc Inc Καταλυόμενη μέ?οδος εστέρος-6-σακχαρόζης.
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
JP4168168B2 (ja) * 1995-11-28 2008-10-22 テート アンド ライル パブリック リミテッド カンパニー 改良スクロース−６−エステル化法

Also Published As

Publication number Publication date
ATE292139T1 (de) 2005-04-15
CN1210286C (zh) 2005-07-13
KR100769532B1 (ko) 2007-10-23
GB2365424A (en) 2002-02-20
IL152599A (en) 2007-09-20
IL152599A0 (en) 2003-06-24
MXPA03000986A (es) 2003-10-14
JP2004505092A (ja) 2004-02-19
DE60109787T2 (de) 2006-05-04
KR20030020885A (ko) 2003-03-10
CA2417404A1 (en) 2002-02-07
CA2417404C (en) 2008-09-09
US20030158404A1 (en) 2003-08-21
EP1305326A1 (en) 2003-05-02
CN1446223A (zh) 2003-10-01
ES2239149T3 (es) 2005-09-16
WO2002010180A1 (en) 2002-02-07
KR20070094671A (ko) 2007-09-20
GB2365424B (en) 2002-06-26
DE60109787D1 (de) 2005-05-04
AU7087501A (en) 2002-02-13
AU2001270875B2 (en) 2006-01-12
EP1305326B1 (en) 2005-03-30
RU2261252C2 (ru) 2005-09-27
JP4536321B2 (ja) 2010-09-01
RU2005120725A (ru) 2007-01-10
PT1305326E (pt) 2005-06-30
US6939962B2 (en) 2005-09-06
GB0018784D0 (en) 2000-09-20

Similar Documents

Publication Publication Date Title
BR0111624A (pt) Método aperfeiçoado para a sìntese de sacarose-6-ésteres
RU2003102627A (ru) Усовершенствованный способ синтеза сложных 6-эфиров сахарозы
Zhao et al. A simple and convenient method for the synthesis of pyranoid glycals
KR910002885A (ko) 수크로오즈-6-에스테르의 염소화 방법
Posner et al. Conversion of glycosyl fluorides into c-glycosides using organoaluminum reagents. Stereospecific alkylation at C-6 of a pyranose sugar
US5440026A (en) Process for the preparation of sucrose 6-esters
Pezzella et al. Oxidative polymerisation of 5, 6-dihydroxyindole-2-carboxylic acid to melanin: A new insight
US9371349B2 (en) Low temperature, vacuum assisted chlorination of sucrose-6-esters free of overchlorinated by-products as intermediates for the production of the artificial sweetener, sucralose
Ahmed et al. Palladium catalysed carbonylation of 2-iodoglycals for the synthesis of C-2 carboxylic acids and aldehydes taking formic acid as a carbonyl source
RU96122529A (ru) Способы получения сложного эфира сахарозы по положению 6.
CA2191412A1 (en) Improved sucrose-6-ester process
Amiot et al. New approach for the synthesis of c-di-GMP and its analogues
WO2007023496A3 (en) Process of preparing bromopicrin
Fröhlich et al. 2, 2, 2-Trifluoroethyl 6-thio-β-D-glucopyranoside as a selective tag for cysteines in proteins
Thurber et al. Ring contractions of 5-diazouracils. I. Conversions of 5-diazouracils into 1, 2, 3-triazoles by hydrolysis and methanolysis
Aoki et al. Formation of coumarins by palladium (II)-catalyzed reaction of phenols with ethyl acrylates
Vargas-Berenguel et al. Convenient synthesis of O-(2-acitamido-2-deoxy-β-D-glucopyranosyl)-serine and-threonine building blocks for solid-phase glycopeptide assembly
Cassayre et al. Application of Mn (III)-catalysed olefin hydration reaction to the selective functionalisation of avermectin B1
Gold et al. 1, 3, 5-Tri-O-acetyl-2-deoxy-α, β-D-ERYTHRO-Pentofuranose from 2-Deoxy-D-ERYTHRO-Pentose
Isobe et al. Aza-Henry Reaction Using DMSO as a Solvent
KR840002765A (ko) 2-히드록시나프탈렌-6-카르복실산의 선택적 제조방법
Nisic et al. Stereoselective synthesis of glycosyl amides by traceless Staudinger ligation of unprotected glycosyl azides
Cane et al. Polyether biosynthesis. 3. Origin of the carbon skeleton and oxygen atoms of lenoremycin
Chan et al. Evidence for Bicyclic Oxonium Ions in the Nitrous Acid Deamination of Benzyl 2-amino-4, 6-O-benzylidene-2-deoxy-D-glucopyranosides
FR2601369B1 (fr) Procede de preparation de dianhydrides du fructofuranose et leur utilisation comme additifs alimentaires.

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: TATE AND LYLE TECHNOLOGY LIMITED (GB)

Free format text: TRANSFERIDO DE: TATE AND LYLE PUBLIC LIMITED COMPANY

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.