BR0107998A - Método para produção de um preparo antiviral imunotrópico - Google Patents
Método para produção de um preparo antiviral imunotrópicoInfo
- Publication number
- BR0107998A BR0107998A BR0107998-0A BR0107998A BR0107998A BR 0107998 A BR0107998 A BR 0107998A BR 0107998 A BR0107998 A BR 0107998A BR 0107998 A BR0107998 A BR 0107998A
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- solution
- dna
- hyperchromatic
- homogenate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"MéTODO PARA PRODUçãO DE UM PREPARO ANTIVIRAL IMUNOTRóPICO". A invenção refere-se a uma indústria de produto químico farmacêutico, em particular um método para produzir um preparo imunotrópico exibindo uma atividade antiviral em relação aos vírus de RNA e de DNA. Com a finalidade de produzir o preparo inventivo, esturjão ou milt de salmão livre de gordura, ou um timo de bezerro, ou sangue de galinha, ou fígado de suíno é pulverizado e homogeneizado em uma solução salina de citrato. O homogeneizado produzido é incubado na presença de um detergente, uma solução clorada de cálcio sendo adicionada a uma temperatura elevada. Depois, o referido homogeneizado é tratado por ultra-som, um sorvente e detergente e concentrado, desse modo produzindo um sedimento amorfo branco de DNA, o qual possui as seguintes características: uma massa molecular variando de 270 a 500 kD, uma ação hipercromática não menor que 37%, um conteúdo de proteína menor que 1%. O sedimentado de DNA é seco e o pó obtido é diluído em uma solução aquosa dos seguintes metais de transição: Zn, Co, Mn, Sb, pelo qual uma solução a 1,5% esterilizada possuindo uma ação hipercromática igual a ou superior a 10% é obtida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2000130036/14A RU2172632C1 (ru) | 2000-12-01 | 2000-12-01 | Способ получения иммунотропного противовирусного препарата |
| PCT/RU2001/000171 WO2002043740A1 (fr) | 2000-12-01 | 2001-04-24 | Procede de fabrication d'un produit antiviral immunotropique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0107998A true BR0107998A (pt) | 2002-10-29 |
Family
ID=20242805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0107998-0A BR0107998A (pt) | 2000-12-01 | 2001-04-24 | Método para produção de um preparo antiviral imunotrópico |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1338281B1 (pt) |
| AT (1) | ATE321132T1 (pt) |
| AU (1) | AU2001256888A1 (pt) |
| BR (1) | BR0107998A (pt) |
| CA (1) | CA2399310C (pt) |
| DE (1) | DE60118175T2 (pt) |
| RU (1) | RU2172632C1 (pt) |
| WO (1) | WO2002043740A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2309759C1 (ru) * | 2006-11-03 | 2007-11-10 | Элли Николаевна Каплина | Способ получения апирогенного иммуномодулятора |
| RU2519349C1 (ru) * | 2013-02-26 | 2014-06-10 | Государственное научное учреждение Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии Российской академии сельскохозяйственных наук (ГНУ ВНИВИПФиТ Россельхозакадемии) | Способ комплексного лечения мастита у лактирующих коров |
| RU2739186C1 (ru) * | 2020-04-21 | 2020-12-21 | Александр Евгеньевич Ладыгин | Способ получения противовирусного лекарственного средства |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU570853B2 (en) * | 1985-08-26 | 1988-03-24 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Inhibition of infectivity and cytopathic effect of htlv-111/ lav by purine bases |
| WO1993010793A1 (en) * | 1991-12-03 | 1993-06-10 | Jury Petrovich Vainberg | Antivirus agent |
| US5547684A (en) * | 1993-02-10 | 1996-08-20 | Pharmec Company | Cosmetic composition containing a DNA-sodium salt and methods of making and using the same |
| RU2005724C1 (ru) * | 1993-04-29 | 1994-01-15 | Юрий Петрович Вайнберг | Способ производства натриевой соли дезоксирибонуклеиновой кислоты из животного сырья и установка для его осуществления |
| RU2043767C1 (ru) * | 1993-05-24 | 1995-09-20 | Научно-производственное предприятие "Фармэк" | Способ подавления вич-инфекции |
| WO1994028153A2 (fr) * | 1993-05-24 | 1994-12-08 | Nauchno-Proizvodstvennoe Predpriyatie 'farmek' | Adn de faible masse moleculaire tiree de laitance d'esturgeon, procede d'obtention de l'adn et preparation pharmaceutique a base de celui-ci |
| RU2041885C1 (ru) * | 1993-05-31 | 1995-08-20 | Научно-производственный центр "Фармзащита" МЗ РФ | Способ получения порошка натриевой соли дезоксирибонуклеиновой кислоты из молок рыб |
| RU2055837C1 (ru) * | 1994-05-31 | 1996-03-10 | Научно-производственный центр "Фармзащита" | Способ получения стерильного раствора натриевой соли дезоксирибонуклеиновой кислоты |
| RU2108797C1 (ru) * | 1994-11-09 | 1998-04-20 | Закрытое акционерное общество "Фаркавер" | Способ получения антивирусного препарата на основе днк |
| WO1996009832A1 (fr) * | 1994-09-29 | 1996-04-04 | Nauchno-Proizvodstvennoe Predpriyatie 'farmek' | Hybride d'adn-arn et preparation d'adn, procedes d'obtention dudit hybride et de ladite preparation a partir de laitance d'esturgeon, et compose pharmaceutique a base dudit hybride d'adn-arn |
| RU2136286C1 (ru) * | 1996-01-22 | 1999-09-10 | Каплина Элли Николаевна | Противовирусное средство к рнк- и днк-содержащим вирусам |
| RU2158592C1 (ru) * | 1999-12-29 | 2000-11-10 | Каплина Элли Николаевна | Противовирусное иммунотропное средство |
-
2000
- 2000-12-01 RU RU2000130036/14A patent/RU2172632C1/ru active
-
2001
- 2001-04-24 AT AT01930355T patent/ATE321132T1/de active
- 2001-04-24 CA CA2399310A patent/CA2399310C/en not_active Expired - Fee Related
- 2001-04-24 EP EP01930355A patent/EP1338281B1/en not_active Expired - Lifetime
- 2001-04-24 BR BR0107998-0A patent/BR0107998A/pt not_active IP Right Cessation
- 2001-04-24 AU AU2001256888A patent/AU2001256888A1/en not_active Abandoned
- 2001-04-24 WO PCT/RU2001/000171 patent/WO2002043740A1/ru active IP Right Grant
- 2001-04-24 DE DE60118175T patent/DE60118175T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60118175D1 (de) | 2006-05-11 |
| WO2002043740A1 (fr) | 2002-06-06 |
| DE60118175T2 (de) | 2007-01-25 |
| CA2399310C (en) | 2012-09-18 |
| EP1338281A1 (en) | 2003-08-27 |
| CA2399310A1 (en) | 2002-06-06 |
| ATE321132T1 (de) | 2006-04-15 |
| EP1338281A4 (en) | 2004-03-24 |
| RU2172632C1 (ru) | 2001-08-27 |
| EP1338281B1 (en) | 2006-03-22 |
| AU2001256888A1 (en) | 2002-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009 |