BR0107216A - Compostos estroprogestacionais tópicos com efeito sistêmico - Google Patents

Compostos estroprogestacionais tópicos com efeito sistêmico

Info

Publication number
BR0107216A
BR0107216A BR0107216-1A BR0107216A BR0107216A BR 0107216 A BR0107216 A BR 0107216A BR 0107216 A BR0107216 A BR 0107216A BR 0107216 A BR0107216 A BR 0107216A
Authority
BR
Brazil
Prior art keywords
topical
systemic
compounds
agent
hormonal
Prior art date
Application number
BR0107216-1A
Other languages
English (en)
Inventor
Georges Gray
Bertrand Villet
Jacques Paris
Jean-Louis Thomas
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of BR0107216A publication Critical patent/BR0107216A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Abstract

"COMPOSTOS ESTROPROGESTACIONAIS TóPICOS COM EFEITO SISTêMICO". A presente invenção refere-se ao campo da química terapêutica, e mais particularmente, à produção de novas formas galênicas a serem aplicadas sobre a pele. Esta tem mais particularmente como objeto uma composição hormonal tópica, com efeito, sistêmico para o tratamento hormonal da perimenopausa e da menopausa, bem como para o tratamento de deficiência hormonal ovariana na mulher com amenorréia, caracterizado pelo fato de incluir, como princípios ativos, um composto progestacional derivado da 19-nor progesterona e do estradiol ou de um de seus derivados, um veículo que permite a etapa sistêmica desses princípios ativos, selecionado do grupo constituído por um agente solubilizante, um agente promotor de absorção, um agente formador de filme, um agente gelificante e suas misturas, associado ou misturado com excipientes apropriados para a realização de uma forma farmacêutica gelificada e/ou na forma de filme.
BR0107216-1A 2000-09-15 2001-09-14 Compostos estroprogestacionais tópicos com efeito sistêmico BR0107216A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0011791A FR2814074B1 (fr) 2000-09-15 2000-09-15 Nouvelles compositions estro-progestatives topiques a effet systemique
PCT/FR2001/002865 WO2002022132A2 (fr) 2000-09-15 2001-09-14 Nouvelles compositions estro-progestatives topiques a effet systemique

Publications (1)

Publication Number Publication Date
BR0107216A true BR0107216A (pt) 2002-07-09

Family

ID=8854345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107216-1A BR0107216A (pt) 2000-09-15 2001-09-14 Compostos estroprogestacionais tópicos com efeito sistêmico

Country Status (20)

Country Link
US (1) US7030104B2 (pt)
EP (1) EP1265617B1 (pt)
JP (1) JP2004508405A (pt)
CN (1) CN1407898A (pt)
AT (1) ATE330614T1 (pt)
AU (1) AU778889B2 (pt)
BR (1) BR0107216A (pt)
CA (1) CA2391162A1 (pt)
CZ (1) CZ20021691A3 (pt)
DE (1) DE60120931D1 (pt)
DZ (1) DZ3221A1 (pt)
FR (1) FR2814074B1 (pt)
HK (1) HK1054332A1 (pt)
HU (1) HUP0204349A3 (pt)
IL (1) IL149448A0 (pt)
MA (2) MA26834A1 (pt)
MX (1) MXPA02004930A (pt)
NO (1) NO20022292L (pt)
WO (1) WO2002022132A2 (pt)
ZA (1) ZA200203439B (pt)

Families Citing this family (47)

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WO2001030356A1 (fr) 1999-10-25 2001-05-03 Laboratoire Theramex Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
US20020141970A1 (en) * 2001-03-05 2002-10-03 Pettit Dean K. Stable aqueous solutions of granulocyte macrophage colony-stimulating factor
TW200404548A (en) * 2002-06-25 2004-04-01 Wyeth Corp Pharmaceutical composition containing cyclothiocarbamate derivatives in treatment of hormone-related conditions
FR2848112B1 (fr) * 2002-12-10 2007-02-16 Besins Int Belgique Composition pharmaceutique pour administration transdermique ou transmuqueuse comprenant au moins un progestatif et/ou au moins un oestrogene, son procede de preparation et ses utilisations
AU2003296810A1 (en) * 2002-12-10 2004-07-09 Besins International Belgique Pharmaceutical composition for transdermal or transmucous administration comprising a progestin or an estrogen, method for preparing same and uses thereof
FR2851470B1 (fr) 2003-02-20 2007-11-16 Besins Int Belgique Composition pharmaceutique pour administration transdermique ou transmuqueuse
PT1670433E (pt) 2003-10-10 2012-02-08 Ferring Bv Fórmula farmacológica transdérmica para a minimização de resíduos na pele
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
JP4705343B2 (ja) * 2004-07-09 2011-06-22 日東電工株式会社 経皮吸収製剤用基剤およびこれを用いた皮膚貼付製剤
CN101107015B (zh) * 2005-01-19 2013-01-23 日本全药工业株式会社 乳腺炎用注入剂
US20070088012A1 (en) * 2005-04-08 2007-04-19 Woun Seo Method of treating or preventing type-2 diabetes
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
US10016442B2 (en) * 2005-06-16 2018-07-10 Allergan Pharmaceuticals International Limited Estrogen compositions for vaginal administration
WO2006138715A1 (en) * 2005-06-16 2006-12-28 Warner Chilcott Company, Inc. Estrogen compositions for vaginal administration
CN101232869B (zh) * 2005-06-16 2016-03-02 沃纳奇尔科特有限责任公司 局部给药的凝胶组合物
SI1937276T1 (sl) 2005-10-12 2013-04-30 Unimed Pharmaceuticals, Llc C/O Abbott Laboratoires 100 Abbott Park Road Izboljšani testosteronski gel in postopek uporabe
US20070254036A1 (en) * 2006-04-13 2007-11-01 Besins Healthcare Sa Treatment of menopause associated symptoms
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US7772213B2 (en) * 2006-07-27 2010-08-10 Nathan Strick Composition for the treatment of inflammatory conditions
FR2924942B1 (fr) * 2007-12-14 2012-06-15 Pf Medicament Compositions pharmaceutiques transcutanees contenant une hormone steroidienne
US10080760B2 (en) 2009-10-27 2018-09-25 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising active agents
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2016018993A1 (en) 2014-07-29 2016-02-04 Therapeuticsmd, Inc. Transdermal cream
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
CN107007611B (zh) * 2017-06-02 2020-04-14 上海市计划生育科学研究所 醋酸诺美孕酮在制备治疗子宫内膜癌的药物中的应用
WO2019140087A1 (en) 2018-01-10 2019-07-18 Celista Pharmaceuticals Llc Testosterone transdermal spray with film
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
FR2737411B1 (fr) * 1995-08-01 1997-10-17 Theramex Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques
EP0785212A1 (en) * 1996-01-22 1997-07-23 Laboratoire Theramex New 19-nor-pregnene derivatives
EP0785211A1 (en) * 1996-01-22 1997-07-23 Laboratoire Theramex New substituted 19-nor-pregnane derivatives
WO2001030355A1 (fr) * 1999-10-25 2001-05-03 Laboratoire Theramex Medicament contraceptif a base d'un progestatif et d'un estrogene et son mode de preparation
FR2754179B1 (fr) * 1996-10-08 1998-12-24 Theramex Nouvelle composition hormononale et son utilisation
FR2776191B1 (fr) * 1998-03-23 2002-05-31 Theramex Composition hormonale topique a effet systemique
WO2001030356A1 (fr) * 1999-10-25 2001-05-03 Laboratoire Theramex Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation

Also Published As

Publication number Publication date
MA26843A1 (fr) 2004-12-20
WO2002022132A2 (fr) 2002-03-21
DE60120931D1 (de) 2006-08-03
AU9002601A (en) 2002-03-26
US7030104B2 (en) 2006-04-18
US20030181430A1 (en) 2003-09-25
CZ20021691A3 (cs) 2002-10-16
AU778889B2 (en) 2004-12-23
NO20022292D0 (no) 2002-05-14
JP2004508405A (ja) 2004-03-18
WO2002022132A3 (fr) 2002-09-12
EP1265617B1 (fr) 2006-06-21
ATE330614T1 (de) 2006-07-15
CA2391162A1 (fr) 2002-03-21
NO20022292L (no) 2002-07-15
HUP0204349A2 (en) 2003-05-28
HUP0204349A3 (en) 2005-03-29
CN1407898A (zh) 2003-04-02
ZA200203439B (en) 2003-08-18
DZ3221A1 (fr) 2002-03-21
FR2814074B1 (fr) 2003-03-07
HK1054332A1 (zh) 2003-11-28
FR2814074A1 (fr) 2002-03-22
MA26834A1 (fr) 2004-12-20
MXPA02004930A (es) 2005-02-17
IL149448A0 (en) 2002-11-10
EP1265617A2 (fr) 2002-12-18
WO2002022132A8 (fr) 2003-03-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.