BR0014922A - Derivados de imidazol como inibidores de fosfodiesterase vii - Google Patents
Derivados de imidazol como inibidores de fosfodiesterase viiInfo
- Publication number
- BR0014922A BR0014922A BR0014922-5A BR0014922A BR0014922A BR 0014922 A BR0014922 A BR 0014922A BR 0014922 A BR0014922 A BR 0014922A BR 0014922 A BR0014922 A BR 0014922A
- Authority
- BR
- Brazil
- Prior art keywords
- imidazole derivatives
- vii
- phosphodiesterase inhibitors
- relates
- hal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
Abstract
"DERIVADOS DE IMIDAZOL COMO INIBIDORES DE FOSFODIESTERASE VII". A invenção refere-se a derivados de imidazol de fórmula (I), onde R^ 1^ significa H, A, benzila, indan-5-ila, 1,2,3,4-tetraidronaftalen-5-ila, dibenzotiofen-2-ila ou fenila que é não-substituída ou substituída uma, duas ou três vezes por meio de Hal, A, A-CO-NH, benzilóxi, alcóxi, COOH ou COOA, R^ 2^ significa H ou A, X significa O ou S, Hal significa F, Cl, Br ou l, e A significa alquila com 1 a 6 átomos de C. A invenção também refere-se aos sais e/ou solvatos fisiologicamente aceitáveis dos compostos que atuam como inibidores de fosfodiesterase VII. A invenção refere-se adicionalmente ao uso dos mesmos para produzir um medicamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19950647A DE19950647A1 (de) | 1999-10-21 | 1999-10-21 | Imidazolderivate als Phosphodiesterase VII-Hemmer |
PCT/EP2000/009926 WO2001029049A2 (de) | 1999-10-21 | 2000-10-10 | Imidazolderivate als phosphodiesterase vii-hemmer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0014922A true BR0014922A (pt) | 2002-06-11 |
Family
ID=7926352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0014922-5A BR0014922A (pt) | 1999-10-21 | 2000-10-10 | Derivados de imidazol como inibidores de fosfodiesterase vii |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1222193B1 (pt) |
JP (1) | JP2003512381A (pt) |
KR (1) | KR20020060201A (pt) |
CN (1) | CN1382146A (pt) |
AR (1) | AR026198A1 (pt) |
AT (1) | ATE247121T1 (pt) |
AU (1) | AU780788B2 (pt) |
BR (1) | BR0014922A (pt) |
CA (1) | CA2388314C (pt) |
CZ (1) | CZ293751B6 (pt) |
DE (2) | DE19950647A1 (pt) |
DK (1) | DK1222193T3 (pt) |
ES (1) | ES2200957T3 (pt) |
HU (1) | HUP0203139A3 (pt) |
MX (1) | MXPA02003952A (pt) |
NO (1) | NO20021846L (pt) |
PL (1) | PL355020A1 (pt) |
PT (1) | PT1222193E (pt) |
RU (1) | RU2259199C2 (pt) |
SK (1) | SK4922002A3 (pt) |
WO (1) | WO2001029049A2 (pt) |
ZA (1) | ZA200203995B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2439784C (en) | 2001-12-13 | 2010-11-02 | Daiichi Suntory Pharma Co., Ltd. | Pyrazolopyrimidinone derivatives having pde7 inhibiting action |
DE10163991A1 (de) * | 2001-12-24 | 2003-07-03 | Merck Patent Gmbh | Pyrrolo-pyrimidine |
JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するイミダゾトリアジノン誘導体 |
JP2006219373A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するピリジニルピラゾロピリミジノン誘導体 |
MX2007000214A (es) | 2004-07-01 | 2007-05-10 | Asubio Pharma Co Ltd | Derivado de tienopirazol que tiene actividad inhibidora de pde 7. |
MX2009010450A (es) | 2007-03-27 | 2009-11-23 | Omeros Corp | El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento. |
US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
KR20220047894A (ko) | 2010-11-08 | 2022-04-19 | 오메로스 코포레이션 | Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료 |
US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4305954A (en) * | 1981-02-11 | 1981-12-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones |
CA2346937A1 (en) * | 1998-10-15 | 2000-04-27 | Per O. G. Arkhammar | Specific therapeutic interventions obtained by interference with redistribution and/or targeting |
WO2000068230A1 (en) * | 1999-05-05 | 2000-11-16 | Darwin Discovery Limited | 9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7 inhibitors |
-
1999
- 1999-10-21 DE DE19950647A patent/DE19950647A1/de not_active Withdrawn
-
2000
- 2000-10-10 RU RU2002111413/15A patent/RU2259199C2/ru not_active IP Right Cessation
- 2000-10-10 ES ES00972714T patent/ES2200957T3/es not_active Expired - Lifetime
- 2000-10-10 AT AT00972714T patent/ATE247121T1/de not_active IP Right Cessation
- 2000-10-10 CZ CZ20021251A patent/CZ293751B6/cs not_active IP Right Cessation
- 2000-10-10 KR KR1020027004903A patent/KR20020060201A/ko not_active Application Discontinuation
- 2000-10-10 PL PL00355020A patent/PL355020A1/xx unknown
- 2000-10-10 MX MXPA02003952A patent/MXPA02003952A/es unknown
- 2000-10-10 DE DE50003309T patent/DE50003309D1/de not_active Expired - Lifetime
- 2000-10-10 WO PCT/EP2000/009926 patent/WO2001029049A2/de active IP Right Grant
- 2000-10-10 DK DK00972714T patent/DK1222193T3/da active
- 2000-10-10 JP JP2001531847A patent/JP2003512381A/ja active Pending
- 2000-10-10 BR BR0014922-5A patent/BR0014922A/pt not_active IP Right Cessation
- 2000-10-10 AU AU11356/01A patent/AU780788B2/en not_active Ceased
- 2000-10-10 EP EP00972714A patent/EP1222193B1/de not_active Expired - Lifetime
- 2000-10-10 SK SK492-2002A patent/SK4922002A3/sk unknown
- 2000-10-10 PT PT00972714T patent/PT1222193E/pt unknown
- 2000-10-10 HU HU0203139A patent/HUP0203139A3/hu unknown
- 2000-10-10 CA CA002388314A patent/CA2388314C/en not_active Expired - Fee Related
- 2000-10-10 CN CN00814402A patent/CN1382146A/zh active Pending
- 2000-10-20 AR ARP000105542A patent/AR026198A1/es unknown
-
2002
- 2002-04-19 NO NO20021846A patent/NO20021846L/no not_active Application Discontinuation
- 2002-05-20 ZA ZA200203995A patent/ZA200203995B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1222193A2 (de) | 2002-07-17 |
ES2200957T3 (es) | 2004-03-16 |
NO20021846D0 (no) | 2002-04-19 |
DE19950647A1 (de) | 2001-04-26 |
DE50003309D1 (de) | 2003-09-18 |
PL355020A1 (en) | 2004-03-22 |
RU2259199C2 (ru) | 2005-08-27 |
CA2388314C (en) | 2009-06-16 |
DK1222193T3 (da) | 2003-12-01 |
NO20021846L (no) | 2002-04-19 |
SK4922002A3 (en) | 2002-09-10 |
AU780788B2 (en) | 2005-04-14 |
HUP0203139A2 (hu) | 2003-01-28 |
PT1222193E (pt) | 2003-12-31 |
MXPA02003952A (es) | 2004-09-06 |
HUP0203139A3 (en) | 2004-12-28 |
CA2388314A1 (en) | 2001-04-26 |
CZ293751B6 (cs) | 2004-07-14 |
CN1382146A (zh) | 2002-11-27 |
KR20020060201A (ko) | 2002-07-16 |
JP2003512381A (ja) | 2003-04-02 |
ATE247121T1 (de) | 2003-08-15 |
ZA200203995B (en) | 2003-10-29 |
EP1222193B1 (de) | 2003-08-13 |
WO2001029049A3 (de) | 2001-11-01 |
AR026198A1 (es) | 2003-01-29 |
WO2001029049A2 (de) | 2001-04-26 |
CZ20021251A3 (cs) | 2002-07-17 |
AU1135601A (en) | 2001-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |