BR0013307A - Compostos quìmicos de indol, seus usos e métodos de preparação, método de tratamento, composição e método de fabricação de uma composição farmacêutica que os contêm - Google Patents
Compostos quìmicos de indol, seus usos e métodos de preparação, método de tratamento, composição e método de fabricação de uma composição farmacêutica que os contêmInfo
- Publication number
- BR0013307A BR0013307A BR0013307-8A BR0013307A BR0013307A BR 0013307 A BR0013307 A BR 0013307A BR 0013307 A BR0013307 A BR 0013307A BR 0013307 A BR0013307 A BR 0013307A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- carbo
- aryloxy
- alkoxy
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
Abstract
"COMPOSTOS QUìMICOS DE INDOL, SEUS USOS E MéTODOS DE PREPARAçãO, MéTODO DE TRATAMENTO, COMPOSIçãO E MéTODO DE FABRICAçãO DE UMA COMPOSIçãO FARMACêUTICA QUE OS CONTêM". Composto químico da Fórmula ( I ), em que R~ 1~, e R~ 2~ são selecionados independentemente a partir de hidrogênio e alquila; R~ 3~ é alquila; R~ 4~, R~ 6~ e R~ 7~ são selecionados independentemente a partir de hidrogênio, halogênio, hidróxi, alquila, arila, amino, alquilamino, dialquilamino, alcóxi, arilóxi, alquiltio, alquilsulfoxila, alquilsulfonila, nitro, carbonitrila, carbo-alcóxi, carbo-arilóxi e carboxila; R~ 5~ é selecionado a partir de hidrogênio, halogênio, hidróxi, alquila, arila, amino, alquilamino, dialquilamino, alcóxi, arilóxi, alquiltio, alquilsulfoxila, alquilsulfonila, nitro, carbonitrila, carbo-alcóxi, carbo-arilóxi e carboxila; A é um anel heterocíclico aromático ou parcialmente insaturado de cinco ou seis membros ou um anel carbocíclico parcialmente insaturado de cinco ou seis membros, em que, se A for um anel carbocíclico parcialmente insaturado de cinco ou seis membros, pelo menos um dentre R~ 4~ a R~ 7~ é diferente de hidrogênio, e seus sais, compostos de adição e pró-drogas farmaceuticamente aceitáveis; e a sua utilização em terapia, particularmente como agonista ou antagonista de um receptor de 5HT, particularmente um receptor de 5HT~ 2c~, no tratamento, por exemplo, de disfunções do sistema nervoso central; danos ao sistema nervoso central; disfunções cardiovasculares; disfunções gastrointestinais, diabetes insipidus; apnéia do sono e, particularmente, para o tratamento da obesidade.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9918962.3A GB9918962D0 (en) | 1999-08-11 | 1999-08-11 | Chemical compounds xxii |
PCT/GB2000/003011 WO2001012603A1 (en) | 1999-08-11 | 2000-08-04 | Indole derivatives, process for their preparation, pharmaceutical compositions containing them and their medicinal application |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0013307A true BR0013307A (pt) | 2002-05-28 |
Family
ID=10858982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0013307-8A BR0013307A (pt) | 1999-08-11 | 2000-08-04 | Compostos quìmicos de indol, seus usos e métodos de preparação, método de tratamento, composição e método de fabricação de uma composição farmacêutica que os contêm |
Country Status (21)
Country | Link |
---|---|
US (1) | US6706750B1 (pt) |
EP (1) | EP1202965B1 (pt) |
JP (1) | JP2003507367A (pt) |
KR (1) | KR100740172B1 (pt) |
CN (1) | CN1187330C (pt) |
AR (1) | AR037222A1 (pt) |
AT (1) | ATE279392T1 (pt) |
AU (1) | AU773337B2 (pt) |
BR (1) | BR0013307A (pt) |
CA (1) | CA2377646A1 (pt) |
DE (1) | DE60014918T2 (pt) |
DK (1) | DK1202965T3 (pt) |
ES (1) | ES2228588T3 (pt) |
GB (1) | GB9918962D0 (pt) |
MX (1) | MXPA01013235A (pt) |
PE (1) | PE20010574A1 (pt) |
PT (1) | PT1202965E (pt) |
TR (1) | TR200200352T2 (pt) |
UY (1) | UY26291A1 (pt) |
WO (1) | WO2001012603A1 (pt) |
ZA (1) | ZA200110217B (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9902047D0 (en) * | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
EP1854798A3 (en) * | 2000-09-19 | 2007-11-28 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
ATE403647T1 (de) * | 2000-10-16 | 2008-08-15 | Hoffmann La Roche | Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden |
ATE406371T1 (de) * | 2000-11-02 | 2008-09-15 | Us Gov Health & Human Serv | Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung |
AR031199A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
AR031202A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
AR031200A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
CA2449899C (en) | 2000-11-20 | 2010-04-06 | Biovitrum Ab | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
US20040087548A1 (en) | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
HUP0500096A3 (en) * | 2001-12-19 | 2012-08-28 | Bristol Myers Squibb Co | Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function, process for producing them and pharmaceutical compositions containing them |
TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
CA2485537A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
WO2004063156A1 (en) * | 2003-01-08 | 2004-07-29 | Biovitrum Ab | Novel indole derivates as fabp-4 inhibitors |
CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
GB0314967D0 (en) * | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
US8076352B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
EP1737461B1 (en) | 2004-03-15 | 2012-12-12 | PTC Therapeutics, Inc. | Carboline derivatives useful in the inhibition of angiogenesis |
US8076353B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
EP1732543B1 (en) * | 2004-03-15 | 2017-05-10 | PTC Therapeutics, Inc. | Tetracyclic carboline deratives for inhibiting angiogenesis |
WO2006012310A2 (en) * | 2004-06-25 | 2006-02-02 | Genzyme Corporation | Carbazole derivatives for treating polycystic kidney disease |
EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
CN101119717A (zh) * | 2004-11-23 | 2008-02-06 | Ptc医疗公司 | 用作抑制vegf产生的活性剂的取代酚 |
CA2588607A1 (en) * | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
GB2422828A (en) * | 2005-02-03 | 2006-08-09 | Hunter Fleming Ltd | Tricyclic cytoprotective compounds comprising an indole residue |
AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
WO2007132841A1 (ja) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物およびその用途 |
EP2216023A4 (en) | 2007-11-15 | 2013-03-13 | Takeda Pharmaceutical | CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF |
US20120253036A1 (en) | 2009-12-11 | 2012-10-04 | Yukinori Nagakura | Agent for treating fibromyalgia |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
EP3733204A4 (en) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE |
WO2023114238A1 (en) * | 2021-12-15 | 2023-06-22 | Delix Therapeutics, Inc. | Aryloxy psychoplastogens and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2541211A (en) | 1948-10-15 | 1951-02-13 | Searle & Co | Tertiary-aminoalkyl-tetrahydrocarbazoles |
US2687414A (en) | 1948-11-26 | 1954-08-24 | Searle & Co | Method for producing aromatic aminoalkyl amines |
DE930988C (de) | 1953-01-01 | 1955-07-28 | Bayer Ag | Verfahren zur Herstellung von basisch alkylierten Tetrahydrocarbazolen oder Indolen |
US3151120A (en) * | 1961-08-15 | 1964-09-29 | Ciba Geigy Corp | Thieno [3, 2-b] indole esters and amides |
US3133930A (en) * | 1961-08-15 | 1964-05-19 | Ciba Geigy Corp | Ester and amide derivatives of thieno-[3, 2-b] indole 3-carboxylic acids |
NL133522C (pt) | 1961-10-24 | |||
US3329571A (en) | 1961-10-24 | 1967-07-04 | American Home Prod | Methods for treating depression |
US3142678A (en) * | 1962-01-09 | 1964-07-28 | American Home Prod | Amino substituted penthienoindoles |
TW270114B (pt) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
TW403738B (en) | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
JP3560986B2 (ja) | 1997-01-13 | 2004-09-02 | 山之内製薬株式会社 | 5―ht2c受容体作用薬及びアミノアルキルインダゾール誘導体 |
-
1999
- 1999-08-11 GB GBGB9918962.3A patent/GB9918962D0/en not_active Ceased
-
2000
- 2000-08-04 DK DK00951697T patent/DK1202965T3/da active
- 2000-08-04 AT AT00951697T patent/ATE279392T1/de not_active IP Right Cessation
- 2000-08-04 AU AU64555/00A patent/AU773337B2/en not_active Ceased
- 2000-08-04 US US10/009,568 patent/US6706750B1/en not_active Expired - Fee Related
- 2000-08-04 CA CA002377646A patent/CA2377646A1/en not_active Abandoned
- 2000-08-04 ES ES00951697T patent/ES2228588T3/es not_active Expired - Lifetime
- 2000-08-04 MX MXPA01013235A patent/MXPA01013235A/es active IP Right Grant
- 2000-08-04 BR BR0013307-8A patent/BR0013307A/pt not_active Application Discontinuation
- 2000-08-04 KR KR1020027001108A patent/KR100740172B1/ko not_active IP Right Cessation
- 2000-08-04 DE DE60014918T patent/DE60014918T2/de not_active Expired - Fee Related
- 2000-08-04 WO PCT/GB2000/003011 patent/WO2001012603A1/en active IP Right Grant
- 2000-08-04 CN CNB00811515XA patent/CN1187330C/zh not_active Expired - Fee Related
- 2000-08-04 JP JP2001517501A patent/JP2003507367A/ja active Pending
- 2000-08-04 EP EP00951697A patent/EP1202965B1/en not_active Expired - Lifetime
- 2000-08-04 PT PT00951697T patent/PT1202965E/pt unknown
- 2000-08-04 TR TR2002/00352T patent/TR200200352T2/xx unknown
- 2000-08-09 PE PE2000000807A patent/PE20010574A1/es not_active Application Discontinuation
- 2000-08-10 AR ARP000104120A patent/AR037222A1/es unknown
- 2000-08-11 UY UY26291A patent/UY26291A1/es not_active Application Discontinuation
-
2001
- 2001-12-12 ZA ZA200110217A patent/ZA200110217B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1202965A1 (en) | 2002-05-08 |
CA2377646A1 (en) | 2001-02-22 |
UY26291A1 (es) | 2001-03-16 |
EP1202965B1 (en) | 2004-10-13 |
PT1202965E (pt) | 2005-01-31 |
TR200200352T2 (pt) | 2002-06-21 |
ATE279392T1 (de) | 2004-10-15 |
KR20020015078A (ko) | 2002-02-27 |
WO2001012603A1 (en) | 2001-02-22 |
DK1202965T3 (da) | 2005-02-14 |
MXPA01013235A (es) | 2002-06-04 |
DE60014918T2 (de) | 2005-10-13 |
AR037222A1 (es) | 2004-11-03 |
AU773337B2 (en) | 2004-05-20 |
KR100740172B1 (ko) | 2007-07-16 |
ES2228588T3 (es) | 2005-04-16 |
PE20010574A1 (es) | 2001-05-21 |
US6706750B1 (en) | 2004-03-16 |
JP2003507367A (ja) | 2003-02-25 |
DE60014918D1 (de) | 2004-11-18 |
AU6455500A (en) | 2001-03-13 |
CN1368960A (zh) | 2002-09-11 |
CN1187330C (zh) | 2005-02-02 |
GB9918962D0 (en) | 1999-10-13 |
ZA200110217B (en) | 2002-12-12 |
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