BR0013228A - Método e composições utilizados para modulação de angiogenese usando proteìna quinase raf e ras - Google Patents
Método e composições utilizados para modulação de angiogenese usando proteìna quinase raf e rasInfo
- Publication number
- BR0013228A BR0013228A BR0013228-4A BR0013228A BR0013228A BR 0013228 A BR0013228 A BR 0013228A BR 0013228 A BR0013228 A BR 0013228A BR 0013228 A BR0013228 A BR 0013228A
- Authority
- BR
- Brazil
- Prior art keywords
- ras
- raf
- raf protein
- compositions used
- protein kinase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"MéTODOS E COMPOSIçõES UTILIZADOS PARA MODULAçãO DE ANGIOGENESE USANDO PROTEìNA QUINASE RAP E RAS". A presente invenção descreve métodos para modulação de angiogenese em tecidos utilizando proteína RAS e/ou RAF, proteína RAS ou RAF modificadas, e ácidos nucléicos codificando as mesmas. Particularmente, a invenção descreve métodos para inibição da angiogenese utilizando proteína RAS e/ou RAF inativa, ou ácido nucléico codificando a mesma, ou para potencializar a angiogenese utilizando proteína RAS e/ou RAF ativa, ou ácido nucléico codificando a mesma. A invenção também descreve o uso de um sistema de entrega de gene para fornecer ácido nucléico codificado para proteína RAS ou RAF, ou formas modificadas do mesmo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14892499P | 1999-08-13 | 1999-08-13 | |
| US21595100P | 2000-07-05 | 2000-07-05 | |
| PCT/US2000/021842 WO2001012210A1 (en) | 1999-08-13 | 2000-08-11 | Methods and compositions useful for modulation of angiogenesis using tyrosine kinase raf and ras |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0013228A true BR0013228A (pt) | 2003-06-17 |
Family
ID=26846311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0013228-4A BR0013228A (pt) | 1999-08-13 | 2000-08-11 | Método e composições utilizados para modulação de angiogenese usando proteìna quinase raf e ras |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060040853A1 (pt) |
| EP (1) | EP1210099A4 (pt) |
| JP (1) | JP2003507337A (pt) |
| KR (2) | KR100805098B1 (pt) |
| CN (1) | CN1208087C (pt) |
| AU (1) | AU781877B2 (pt) |
| BR (1) | BR0013228A (pt) |
| CA (1) | CA2380966A1 (pt) |
| CZ (1) | CZ2002449A3 (pt) |
| HK (1) | HK1050856A1 (pt) |
| HU (1) | HUP0300923A3 (pt) |
| MX (1) | MXPA02001553A (pt) |
| NO (1) | NO20020718L (pt) |
| PL (1) | PL364928A1 (pt) |
| RU (1) | RU2257911C2 (pt) |
| SK (1) | SK2142002A3 (pt) |
| WO (1) | WO2001012210A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002223571A1 (en) * | 2000-09-29 | 2002-04-08 | Gsf-Forschungszentrum Fur Umwelt Und Gesundheit, Gmbh | Pharmaceutical compositions comprising polynucleotides encoding a raf protein |
| MX2009009792A (es) * | 2007-03-12 | 2009-09-23 | Cytopia Res Pty Ltd | Compuestos de fenil amino pirimidina y usos de los mismos. |
| RU2486200C2 (ru) * | 2008-01-14 | 2013-06-27 | Дженентек, Инк. | Способы ингибирования ангиогенеза с помощью антагонистов egfl8 |
| EP2329854A3 (de) * | 2009-12-04 | 2014-02-19 | Biotronik VI Patent AG | Implantatbeschichtung mit Nukleinsäuren |
| CN102766601B (zh) * | 2011-11-17 | 2015-12-16 | 中山大学肿瘤防治中心 | 含有可诱导型癌基因的细胞系及其建立方法、应用 |
| CN106686981B (zh) | 2014-06-03 | 2020-03-10 | 赫雷拉 A·索利斯 | 角膜血管生成和角膜扩张疾病的动物模型，其制备方法，以及其使用方法 |
| RU2728870C2 (ru) * | 2017-10-12 | 2020-07-31 | Федеральное государственное бюджетное учреждение "Российский научный центр рентгенорадиологии" Министерства здравоохранения российской федерации (ФГБУ "РНЦРР" Минздрава России) | Полипептиды для лечения онкологических заболеваний |
| US20230218710A1 (en) * | 2020-04-15 | 2023-07-13 | Cohbar, Inc. | Method of treating coronavirus infections |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5156841A (en) * | 1988-08-26 | 1992-10-20 | United States Of America | Anti-tumor vaccine |
| US5618670A (en) * | 1988-08-26 | 1997-04-08 | The United States Of America As Represented By The Department Of Health & Human Services | Detection method for c-raf-1 genes |
| US5656612A (en) * | 1994-05-31 | 1997-08-12 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
| US5597719A (en) * | 1994-07-14 | 1997-01-28 | Onyx Pharmaceuticals, Inc. | Interaction of RAF-1 and 14-3-3 proteins |
| US5795910A (en) * | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| US6300081B1 (en) * | 1996-11-15 | 2001-10-09 | Cornell Research Foundation, Inc. | Activated ras interaction assay |
| WO1999018792A1 (en) * | 1997-10-10 | 1999-04-22 | Johns Hopkins University | Gene delivery compositions and methods |
-
2000
- 2000-08-11 HU HU0300923A patent/HUP0300923A3/hu unknown
- 2000-08-11 AU AU67633/00A patent/AU781877B2/en not_active Ceased
- 2000-08-11 PL PL00364928A patent/PL364928A1/xx not_active Application Discontinuation
- 2000-08-11 MX MXPA02001553A patent/MXPA02001553A/es not_active Application Discontinuation
- 2000-08-11 KR KR1020077010931A patent/KR100805098B1/ko not_active IP Right Cessation
- 2000-08-11 RU RU2002106426/15A patent/RU2257911C2/ru not_active IP Right Cessation
- 2000-08-11 BR BR0013228-4A patent/BR0013228A/pt not_active Application Discontinuation
- 2000-08-11 SK SK214-2002A patent/SK2142002A3/sk unknown
- 2000-08-11 EP EP00955423A patent/EP1210099A4/en not_active Withdrawn
- 2000-08-11 CZ CZ2002449A patent/CZ2002449A3/cs unknown
- 2000-08-11 CN CNB008140952A patent/CN1208087C/zh not_active Expired - Fee Related
- 2000-08-11 WO PCT/US2000/021842 patent/WO2001012210A1/en active IP Right Grant
- 2000-08-11 JP JP2001516555A patent/JP2003507337A/ja not_active Withdrawn
- 2000-08-11 KR KR1020027001943A patent/KR100759241B1/ko not_active IP Right Cessation
- 2000-08-11 CA CA002380966A patent/CA2380966A1/en not_active Abandoned
-
2002
- 2002-02-12 NO NO20020718A patent/NO20020718L/no not_active Application Discontinuation
-
2003
- 2003-05-02 HK HK03103151A patent/HK1050856A1/xx not_active IP Right Cessation
-
2005
- 2005-09-02 US US11/219,264 patent/US20060040853A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20020718D0 (no) | 2002-02-12 |
| WO2001012210A1 (en) | 2001-02-22 |
| RU2257911C2 (ru) | 2005-08-10 |
| CZ2002449A3 (cs) | 2002-08-14 |
| AU6763300A (en) | 2001-03-13 |
| HUP0300923A2 (hu) | 2003-07-28 |
| WO2001012210A9 (en) | 2002-09-12 |
| AU781877B2 (en) | 2005-06-16 |
| NO20020718L (no) | 2002-04-10 |
| PL364928A1 (en) | 2004-12-27 |
| EP1210099A4 (en) | 2006-01-18 |
| US20060040853A1 (en) | 2006-02-23 |
| HK1050856A1 (en) | 2003-07-11 |
| SK2142002A3 (en) | 2002-07-02 |
| KR100805098B1 (ko) | 2008-02-20 |
| KR20020032553A (ko) | 2002-05-03 |
| EP1210099A1 (en) | 2002-06-05 |
| JP2003507337A (ja) | 2003-02-25 |
| MXPA02001553A (es) | 2003-05-23 |
| HUP0300923A3 (en) | 2005-12-28 |
| CN1208087C (zh) | 2005-06-29 |
| KR20070067210A (ko) | 2007-06-27 |
| KR100759241B1 (ko) | 2007-09-18 |
| CA2380966A1 (en) | 2001-02-22 |
| CN1378457A (zh) | 2002-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 10 (VIII), 13 E 25 DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |