BR0013138A - Sìntese de pirazolopirimidinas substituìdas - Google Patents

Sìntese de pirazolopirimidinas substituìdas

Info

Publication number
BR0013138A
BR0013138A BR0013138-5A BR0013138A BR0013138A BR 0013138 A BR0013138 A BR 0013138A BR 0013138 A BR0013138 A BR 0013138A BR 0013138 A BR0013138 A BR 0013138A
Authority
BR
Brazil
Prior art keywords
substituted pyrazolopyrimidines
synthesis
making
improved techniques
techniques
Prior art date
Application number
BR0013138-5A
Other languages
English (en)
Inventor
Raymond S Gross
Keith M Wilcoxen
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of BR0013138A publication Critical patent/BR0013138A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"SìNTESE DE PIRAZOLOPIRIMIDINAS SUBSTITUìDAS". Descreve-se métodos para fabricar pirazolopirimidinas substituídas e mais particularmente N-metil-N-(3-{3-[2-tienil-carbonil]-pirazol-[1,5-<244>-pirimidin-7-il}-fenil )-acetamida. Esses compostos têm utilidade em uma ampla série de indicações, inclusive o tratamento de insónia. Na prática da presente invenção, descreve-se técnicas aperfeiçoadas que não requerem o uso e/ou o isolamento do pirazol intermediário, bem como técnicas aperfeiçoadas para fabricar os próprios intermediários das reações. Essas técnicas oferecem vantagens significativas, inclusive maior eficiência, particularmente no contexto de fabricação em larga escala.
BR0013138-5A 1999-08-10 2000-08-10 Sìntese de pirazolopirimidinas substituìdas BR0013138A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14831499P 1999-08-10 1999-08-10
US14831399P 1999-08-10 1999-08-10
PCT/US2000/021924 WO2001010868A1 (en) 1999-08-10 2000-08-10 Synthesis of substituted pyrazolopyrimidines

Publications (1)

Publication Number Publication Date
BR0013138A true BR0013138A (pt) 2002-04-30

Family

ID=26845740

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013138-5A BR0013138A (pt) 1999-08-10 2000-08-10 Sìntese de pirazolopirimidinas substituìdas

Country Status (19)

Country Link
US (2) US6472528B1 (pt)
EP (1) EP1208102B1 (pt)
JP (1) JP2003506453A (pt)
KR (1) KR20020029917A (pt)
CN (1) CN1152033C (pt)
AT (2) ATE292635T1 (pt)
AU (1) AU768783B2 (pt)
BR (1) BR0013138A (pt)
CA (1) CA2381524A1 (pt)
DE (2) DE60019350T2 (pt)
DK (1) DK1344768T3 (pt)
ES (2) ES2193980T3 (pt)
HK (1) HK1043366B (pt)
IL (2) IL148078A0 (pt)
MX (1) MXPA02001416A (pt)
NO (1) NO322014B1 (pt)
NZ (1) NZ517155A (pt)
PT (2) PT1344768E (pt)
WO (1) WO2001010868A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472528B1 (en) * 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
WO2001013895A2 (en) * 1999-08-26 2001-03-01 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6958420B2 (en) * 2002-07-19 2005-10-25 Board Of Trustees Of Michigan State University Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof
ES2274260T3 (es) * 2002-08-26 2007-05-16 Neurocrine Biosciences, Inc. Nuevo polimorfo de n-metil-n-(3-(3-((2-tienilcarbonil))pirazol-((1,5-alfa))pirimidin-7-il))fenil)acetamida y composiciones y metodos relacionados.
WO2004087637A1 (en) * 2003-03-31 2004-10-14 Takasago International Corporation Production of n-alkylamide compounds
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
CA2553465A1 (en) 2004-01-14 2005-08-04 Mallinckrodt Inc. Two-phase method for the synthesis of selected pyrazolopyrimidines
TW200630368A (en) * 2004-10-18 2006-09-01 Neurocrine Biosciences Inc Hydrate of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and processes and methods related thereto
CN100528875C (zh) * 2005-02-18 2009-08-19 美德（江西）生物科技有限公司 无结晶型态的印地普隆及其制备方法
US20080058351A1 (en) * 2006-06-30 2008-03-06 Concert Pharmaceuticals Inc. Novel heterobicyclic compounds
US20120028045A1 (en) * 2009-03-24 2012-02-02 Glenmark Generics Ltd Processes for the Preparation of Indiplon and Intermediates Thereof
CN102775412B (zh) * 2012-08-21 2013-05-01 四川大学 一种镇静催眠的化合物及其制备方法和用途
CN104016988B (zh) * 2014-06-05 2016-04-13 临海市利民化工有限公司 一种茚地普隆的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2512014A1 (fr) 1981-08-28 1983-03-04 Guerbet Sa Composes bromes utilisables dans des produits opacifiants
US4654347A (en) 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4900836A (en) 1983-06-23 1990-02-13 American Cyanamid Company (3-amino-1H-pyrazol-4-yl) (aryl)methanones
US4521422A (en) 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
NZ221964A (en) 1986-10-03 1990-03-27 Ishihara Sangyo Kaisha Benzoylurea compounds and insecticidal compositions
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
US5538977A (en) 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
JPH0995460A (ja) * 1995-07-27 1997-04-08 Mitsui Petrochem Ind Ltd １，３−ジエーテル類の製造法
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
DE69924480D1 (en) 1998-05-05 2005-05-04 Hoffmann La Roche Pyrazolderivative als p-38 map kinase inhibitoren
US6245759B1 (en) * 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US6472528B1 (en) * 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
IL148905A0 (en) * 1999-09-30 2002-09-12 Neurogen Corp Pfizer Inc Certain alkylene diamine-substituted pyrazolo{1,5,-a}-1,5-pyrimidines and pyrazolo{1,5,-a}-1,3,5-triazines
OA12049A (en) * 1999-09-30 2006-05-02 Neurogen Corp Amino substituted pyrazoloÄ1,5,-aÜ-1,5-pyrimidinesand pyrazoloÄ1,5,-aÜ-1,3,5-triazines.
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists

Also Published As

Publication number Publication date
NO20020645D0 (no) 2002-02-08
DE60019350T2 (de) 2006-03-09
JP2003506453A (ja) 2003-02-18
DK1344768T3 (da) 2005-08-15
CA2381524A1 (en) 2001-02-15
AU6765000A (en) 2001-03-05
ES2240873T3 (es) 2005-10-16
IL148078A (en) 2006-12-10
HK1043366A1 (en) 2002-09-13
ATE235496T1 (de) 2003-04-15
NO20020645L (no) 2002-04-08
DE60001847T2 (de) 2003-12-24
WO2001010868A1 (en) 2001-02-15
DE60001847D1 (de) 2003-04-30
DE60019350D1 (de) 2005-05-12
EP1208102B1 (en) 2003-03-26
CN1372561A (zh) 2002-10-02
NO322014B1 (no) 2006-08-07
KR20020029917A (ko) 2002-04-20
MXPA02001416A (es) 2002-08-12
IL148078A0 (en) 2002-09-12
PT1208102E (pt) 2003-08-29
CN1152033C (zh) 2004-06-02
US20030004346A1 (en) 2003-01-02
ATE292635T1 (de) 2005-04-15
US6472528B1 (en) 2002-10-29
HK1043366B (zh) 2003-11-28
US7034154B2 (en) 2006-04-25
ES2193980T3 (es) 2003-11-16
EP1208102A1 (en) 2002-05-29
NZ517155A (en) 2003-04-29
PT1344768E (pt) 2005-08-31
AU768783B2 (en) 2004-01-08

Similar Documents

Publication Publication Date Title
BR0013138A (pt) Sìntese de pirazolopirimidinas substituìdas
MXPA02011370A (es) Iminoazinas substituidas.
HRP20050288A2 (en) NOVEL POLYMORPH OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5-α]-PYRIMIDIN-7-YL}PHENIL)ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO
YU27304A (sh) Novi dihidropteridinoni, postupak za njihovo dobijanje i njihova primena kao lekova
DE60012188D1 (de) Fungizide
DE60236600D1 (de) Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung
ID26980A (id) Amida-amida baru yang tersubstitusi secara heterosiklik, pembuatan dan penggunaannya
ATE264268T1 (de) Verfahren zur herstellung von zsm-5 und zsm-11
HUP0102615A2 (hu) 2-(2-Klór-fenil)-3,4-dihidro-2H-pirrol-származékok
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
SE9604582D0 (sv) Novel compounds
ATE167671T1 (de) Beta-aminovinylketone, verfahren zur herstellung und ihre verwendung bei der herstellung von beta- diketonen
EP1344768A3 (en) Synthesis of substituted pyrazolopyrimidines
ATE300534T1 (de) Verfahren und zwischenverbindungen zur herstellung von imidazopyridinen
PL343546A1 (en) Processes for preparing intermediates
DK1178985T3 (da) Substituerede thienocycloalk(en)ylamino-1,3,5-triaziner
ATE388953T1 (de) Pyrazolopyrimidine
DE60335805D1 (de) Verfahren zur herstellung von 1,3-dioxolan-nucleosiden
DE50114223D1 (de) Verfahren zur herstellung von 1-substituierten 5-chlor-4methylpyrazolen
MX9704978A (es) 5-aminopirazoles acilados y su empleo para la lucha contra las pestes animales.
MX9606166A (es) Pirazoles substituidos.
HUP0301648A2 (hu) Eljárás 9-amino-szubsztituált 9,10-dihidropirrolo [2,1-b][1,3]-benzotiazepinek előállítására

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements