BR0012871A - Derivados de tienopiranocarboxamida - Google Patents
Derivados de tienopiranocarboxamidaInfo
- Publication number
- BR0012871A BR0012871A BR0012871-6A BR0012871A BR0012871A BR 0012871 A BR0012871 A BR 0012871A BR 0012871 A BR0012871 A BR 0012871A BR 0012871 A BR0012871 A BR 0012871A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- treatment
- urinary tract
- lower urinary
- polyfluoroalkoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 210000001635 urinary tract Anatomy 0.000 abstract 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 polyfluoroalkoxy Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"DERIVADOS DE TIENOPIRANOCARBOXAMIDA". Compostos (I) (R = arila, cicloalquila ou polialoalquila, R~ 1~ = alquila, alcóxi, polifluoroalcóxi, hidróxi ou trifluorometanossulfonilóxi, cada um de R~ 2~ e R~ 3~ independentemente = H, halogênio, alcóxi ou polifluoroalcóxi, n é 0, 1 ou 2) e seus óxidos-N ou sais farmaceuticamente aceitáveis são dotados de seletividade aumentada para o receptor adrenérgico ~ <244>1~ e baixa atividade para diminuir a pressão sang³ínea. Este perfil de atividade torna estes compostos úteis no tratamento de síndromes obstrutivas do trato urinário inferior, incluindo hiperplasia prostática benigna (BPH), reduzir a pressão intra-ocular, no tratamento de arritmia cardíaca e disfunção sexual e erétil, e no tratamento de sintomas de trato urinário inferior (LUTS) e disfunção do trato urinário inferior neurogênico (NLUTD). Os compostos (I) por si, composições farmacêuticas contendo os compostos (I) e usos médicos dos compostos (I) são reivindicados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI001704A IT1313581B1 (it) | 1999-07-30 | 1999-07-30 | Derivati tienopirancarbossamidici. |
| PCT/EP2000/007306 WO2001009140A1 (en) | 1999-07-30 | 2000-07-28 | Thienopyranecarboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012871A true BR0012871A (pt) | 2002-04-16 |
Family
ID=11383457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012871-6A BR0012871A (pt) | 1999-07-30 | 2000-07-28 | Derivados de tienopiranocarboxamida |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1200445B1 (pt) |
| JP (1) | JP2003506379A (pt) |
| KR (1) | KR100705179B1 (pt) |
| CN (1) | CN1155602C (pt) |
| AT (1) | ATE250068T1 (pt) |
| AU (1) | AU759085B2 (pt) |
| BR (1) | BR0012871A (pt) |
| CA (1) | CA2378302A1 (pt) |
| DE (1) | DE60005368T2 (pt) |
| DK (1) | DK1200445T3 (pt) |
| ES (1) | ES2206296T3 (pt) |
| HK (1) | HK1044763A1 (pt) |
| HU (1) | HUP0202106A3 (pt) |
| IL (2) | IL147441A0 (pt) |
| IT (1) | IT1313581B1 (pt) |
| MX (1) | MXPA02000820A (pt) |
| NO (1) | NO20020476L (pt) |
| PL (1) | PL198700B1 (pt) |
| PT (1) | PT1200445E (pt) |
| RU (1) | RU2225409C2 (pt) |
| TW (1) | TWI239958B (pt) |
| WO (1) | WO2001009140A1 (pt) |
| ZA (1) | ZA200200687B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY30111A1 (es) * | 2006-02-03 | 2007-04-30 | Recordati Ireland Ltd | Sales de adicion de acido de n-(3-(4-(2-metoxifenil)-1-piperazinil)-propil)-7-oxo-5-trifluormetil-7h-tieno (3,2-b) piran-3-carboxamida |
| EP2231152B1 (en) * | 2008-01-24 | 2014-01-01 | SignalRX Pharmaceuticals, Inc. | Thienopyranones as kinase inhibitors |
| RU2708690C2 (ru) | 2013-08-08 | 2019-12-11 | Галапагос Нв | Производные тиено[2,3-c]пиранов в качестве cftr модуляторов |
| JP2020506904A (ja) * | 2017-01-27 | 2020-03-05 | シグナルアールエックス ファーマシューティカルズ，インコーポレイテッド | キナーゼ、ブロモドメイン及びチェックポイント阻害剤としてのチエノピラノン及びフラノピラノン |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP930210A2 (en) * | 1992-02-25 | 1995-06-30 | Recordati Chem Pharm | Heterobicyclic compounds and pharmaceutical preparations containing them |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| JP2001512110A (ja) * | 1997-08-01 | 2001-08-21 | レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー | １，４−ジ置換ピペラジン |
-
1999
- 1999-07-30 IT IT1999MI001704A patent/IT1313581B1/it active
-
2000
- 2000-07-28 KR KR1020027001140A patent/KR100705179B1/ko not_active IP Right Cessation
- 2000-07-28 AT AT00958313T patent/ATE250068T1/de not_active IP Right Cessation
- 2000-07-28 TW TW089115124A patent/TWI239958B/zh not_active IP Right Cessation
- 2000-07-28 ES ES00958313T patent/ES2206296T3/es not_active Expired - Lifetime
- 2000-07-28 WO PCT/EP2000/007306 patent/WO2001009140A1/en active IP Right Grant
- 2000-07-28 CA CA002378302A patent/CA2378302A1/en not_active Abandoned
- 2000-07-28 JP JP2001514343A patent/JP2003506379A/ja active Pending
- 2000-07-28 PL PL363115A patent/PL198700B1/pl not_active IP Right Cessation
- 2000-07-28 BR BR0012871-6A patent/BR0012871A/pt not_active Application Discontinuation
- 2000-07-28 RU RU2002105022/04A patent/RU2225409C2/ru not_active IP Right Cessation
- 2000-07-28 PT PT00958313T patent/PT1200445E/pt unknown
- 2000-07-28 DE DE60005368T patent/DE60005368T2/de not_active Expired - Fee Related
- 2000-07-28 CN CNB008109788A patent/CN1155602C/zh not_active Expired - Fee Related
- 2000-07-28 EP EP00958313A patent/EP1200445B1/en not_active Expired - Lifetime
- 2000-07-28 AU AU69882/00A patent/AU759085B2/en not_active Ceased
- 2000-07-28 DK DK00958313T patent/DK1200445T3/da active
- 2000-07-28 HU HU0202106A patent/HUP0202106A3/hu unknown
- 2000-07-28 MX MXPA02000820A patent/MXPA02000820A/es active IP Right Grant
- 2000-07-28 IL IL14744100A patent/IL147441A0/xx active IP Right Grant
-
2002
- 2002-01-02 IL IL147441A patent/IL147441A/en not_active IP Right Cessation
- 2002-01-25 ZA ZA200200687A patent/ZA200200687B/en unknown
- 2002-01-29 NO NO20020476A patent/NO20020476L/no not_active Application Discontinuation
- 2002-08-15 HK HK02105973A patent/HK1044763A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI239958B (en) | 2005-09-21 |
| DE60005368D1 (en) | 2003-10-23 |
| HK1044763A1 (en) | 2002-11-01 |
| ITMI991704A0 (it) | 1999-07-30 |
| PL363115A1 (en) | 2004-11-15 |
| IL147441A (en) | 2007-06-03 |
| EP1200445A1 (en) | 2002-05-02 |
| NO20020476D0 (no) | 2002-01-29 |
| NO20020476L (no) | 2002-01-29 |
| WO2001009140A1 (en) | 2001-02-08 |
| CN1155602C (zh) | 2004-06-30 |
| AU759085B2 (en) | 2003-04-03 |
| JP2003506379A (ja) | 2003-02-18 |
| ATE250068T1 (de) | 2003-10-15 |
| HUP0202106A2 (en) | 2002-10-28 |
| IT1313581B1 (it) | 2002-09-09 |
| PT1200445E (pt) | 2004-02-27 |
| MXPA02000820A (es) | 2004-03-19 |
| HUP0202106A3 (en) | 2004-12-28 |
| CN1365363A (zh) | 2002-08-21 |
| ZA200200687B (en) | 2002-10-30 |
| RU2225409C2 (ru) | 2004-03-10 |
| EP1200445B1 (en) | 2003-09-17 |
| AU6988200A (en) | 2001-02-19 |
| ES2206296T3 (es) | 2004-05-16 |
| PL198700B1 (pl) | 2008-07-31 |
| IL147441A0 (en) | 2002-08-14 |
| DK1200445T3 (da) | 2004-01-12 |
| KR100705179B1 (ko) | 2007-04-06 |
| DE60005368T2 (de) | 2004-07-01 |
| KR20020022785A (ko) | 2002-03-27 |
| ITMI991704A1 (it) | 2001-01-30 |
| CA2378302A1 (en) | 2001-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: RECORDATI IRELAND LIMITED (IE) Free format text: TRANSFERIDO DE: RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |