BR0011732B1 - Vacinas de dna para animais de companhia e de esporte - Google Patents
Vacinas de dna para animais de companhia e de esporte Download PDFInfo
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- BR0011732B1 BR0011732B1 BRPI0011732-3A BR0011732A BR0011732B1 BR 0011732 B1 BR0011732 B1 BR 0011732B1 BR 0011732 A BR0011732 A BR 0011732A BR 0011732 B1 BR0011732 B1 BR 0011732B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9907604A FR2794648B1 (fr) | 1999-06-10 | 1999-06-10 | Vaccins adn pour animaux de compagnie et de sport |
| FR99/07604 | 1999-06-10 | ||
| US14449099P | 1999-07-19 | 1999-07-19 | |
| US60/144,490 | 1999-07-19 | ||
| PCT/FR2000/001592 WO2000077043A2 (fr) | 1999-06-10 | 2000-06-08 | Vaccins adn pour animaux de compagnie et de sport |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0011732A BR0011732A (pt) | 2002-03-05 |
| BR0011732B1 true BR0011732B1 (pt) | 2014-02-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0011732-3A BR0011732B1 (pt) | 1999-06-10 | 2000-06-08 | Vacinas de dna para animais de companhia e de esporte |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1185662B1 (https=) |
| JP (1) | JP2003502345A (https=) |
| KR (1) | KR100768114B1 (https=) |
| AR (1) | AR024334A1 (https=) |
| AU (1) | AU782154C (https=) |
| BR (1) | BR0011732B1 (https=) |
| CA (1) | CA2375320C (https=) |
| CZ (1) | CZ20014392A3 (https=) |
| NZ (1) | NZ515993A (https=) |
| PL (1) | PL210451B1 (https=) |
| WO (1) | WO2000077043A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2804028B1 (fr) * | 2000-01-21 | 2004-06-04 | Merial Sas | Vaccins adn ameliores pour animaux de rente |
| FR2823222B1 (fr) | 2001-04-06 | 2004-02-06 | Merial Sas | Vaccin contre le virus de la fievre du nil |
| FR2825280B1 (fr) * | 2001-06-01 | 2005-04-15 | Merial Sas | Vaccination contre le virus de l'immunodeficience feline |
| WO2005049794A2 (en) | 2003-11-13 | 2005-06-02 | University Of Georgia Research Foundation, Inc. | Methods of characterizing infectious bursal disease virus |
| RS51324B (sr) | 2005-04-25 | 2010-12-31 | Merial Ltd. | Vakcine protiv nipah virusa |
| EP1954308B1 (en) * | 2005-09-16 | 2011-09-07 | Merial Ltd. | Stabilizers for freeze-dried vaccines |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| EP2276495B1 (en) | 2008-04-17 | 2018-11-21 | PDS Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| EP3756684A1 (en) | 2009-05-22 | 2020-12-30 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| US20130197612A1 (en) * | 2010-02-26 | 2013-08-01 | Jack W. Lasersohn | Electromagnetic Radiation Therapy |
| JP6055776B2 (ja) | 2010-11-24 | 2016-12-27 | ジェノセア バイオサイエンシーズ, インコーポレイテッド | 単純ヘルペスウイルス2型に対するワクチン:免疫応答を誘発する組成物及び方法 |
| AU2012340712B2 (en) | 2011-11-23 | 2017-09-14 | Genocea Biosciences, Inc. | Nucleic acid vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response |
| CA2876656C (en) * | 2012-06-15 | 2023-09-26 | Pds Biotechnology Corporation | Cationic lipid vaccine compositions and methods of use |
| CN113144188A (zh) | 2012-09-21 | 2021-07-23 | Pds生物科技公司 | 改进的疫苗组合物和使用方法 |
| CN104164409A (zh) * | 2014-07-18 | 2014-11-26 | 中国人民解放军军事医学科学院军事兽医研究所 | 含有犬gmcsf基因的重组犬瘟热病毒及其制备方法 |
| CN104958283A (zh) * | 2015-06-02 | 2015-10-07 | 北京盛大康成医疗技术有限公司 | 弱碱性皮肤粘膜清洗消毒组合物及其制造方法和用途 |
| CA3005251A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| KR101694676B1 (ko) | 2015-12-10 | 2017-01-10 | 우진 비앤지 주식회사 | 말 선역 질병원인 국내 분리 스트렙토코커스 이콰이 균주 및 이를 포함하는 백신 |
| US10350288B2 (en) | 2016-09-28 | 2019-07-16 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
| WO2019113200A1 (en) | 2017-12-05 | 2019-06-13 | Pds Biotechnology Corporation | Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes |
| US20220054616A1 (en) | 2019-01-04 | 2022-02-24 | Boehringer Ingelheim Animal Health USA Inc. | Attenuated Bordetella Bronchiseptica Strains, Oral Vaccines Containing the Attenuated Strains, and Methods of Making & Use Thereof |
| IL291968A (en) * | 2019-10-09 | 2022-06-01 | Mayo Found Medical Education & Res | Rabies megaloglutin virus and fusion polypeptides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| EP1624068A1 (en) * | 1993-06-01 | 2006-02-08 | Life Technologies Inc. | Genetic immunization with cationic lipids |
| WO1995026751A1 (en) * | 1994-03-30 | 1995-10-12 | Virogenetics Corporation | NUCLEOTIDE AND AMINO ACID SEQUENCES OF CANINE HERPESVIRUS gB, gC and gD AND USES THEREFOR |
| JPH11504631A (ja) * | 1995-04-25 | 1999-04-27 | バイカル インコーポレイテッド | Dna/脂質複合体の単一バイアル製剤 |
| ES2109189B1 (es) * | 1996-03-14 | 1998-05-16 | Iberica Cyanamid | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
| EP0954582A1 (en) * | 1996-04-29 | 1999-11-10 | Andreas Prof. Zurbriggen | Polynucleotide vaccine against canine distemper |
| FR2751226B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique contre les pathologies du cheval |
| FR2751223B1 (fr) * | 1996-07-19 | 1998-12-04 | Rhone Merieux | Formule de vaccin polynucleotidique felin |
| FR2751227B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique contre les pathologies canines, notamment les pathologies respiratoires et digestives |
| WO1998040499A1 (en) * | 1997-03-10 | 1998-09-17 | Heather Lynn Davis | Gene delivery to mucosal epithelium for immunization or therapeutic purposes |
| AU1131200A (en) * | 1998-10-23 | 2000-05-15 | Heska Corporation | Cationic lipid-mediated enhancement of nucleic acid immunization of cats |
-
2000
- 2000-06-08 CA CA2375320A patent/CA2375320C/en not_active Expired - Lifetime
- 2000-06-08 BR BRPI0011732-3A patent/BR0011732B1/pt not_active IP Right Cessation
- 2000-06-08 PL PL352212A patent/PL210451B1/pl unknown
- 2000-06-08 NZ NZ515993A patent/NZ515993A/en not_active IP Right Cessation
- 2000-06-08 KR KR1020017015911A patent/KR100768114B1/ko not_active Expired - Lifetime
- 2000-06-08 CZ CZ20014392A patent/CZ20014392A3/cs unknown
- 2000-06-08 JP JP2001503899A patent/JP2003502345A/ja active Pending
- 2000-06-08 EP EP00940474A patent/EP1185662B1/fr not_active Expired - Lifetime
- 2000-06-08 AU AU55405/00A patent/AU782154C/en not_active Expired
- 2000-06-08 WO PCT/FR2000/001592 patent/WO2000077043A2/fr not_active Ceased
- 2000-06-12 AR ARP000102879A patent/AR024334A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003502345A (ja) | 2003-01-21 |
| CA2375320A1 (en) | 2000-12-21 |
| WO2000077043A3 (fr) | 2001-07-19 |
| PL210451B1 (pl) | 2012-01-31 |
| PL352212A1 (en) | 2003-08-11 |
| AU782154B2 (en) | 2005-07-07 |
| AU5540500A (en) | 2001-01-02 |
| KR100768114B1 (ko) | 2007-10-17 |
| AU782154C (en) | 2006-02-09 |
| EP1185662A2 (fr) | 2002-03-13 |
| WO2000077043A2 (fr) | 2000-12-21 |
| CA2375320C (en) | 2013-02-19 |
| CZ20014392A3 (cs) | 2002-06-12 |
| BR0011732A (pt) | 2002-03-05 |
| KR20020012271A (ko) | 2002-02-15 |
| NZ515993A (en) | 2004-04-30 |
| EP1185662B1 (fr) | 2011-03-02 |
| AR024334A1 (es) | 2002-10-02 |
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