BR0010440A - Processo para preparar inibidores de trombina de peso constante, composto, droga, e, uso de um composto - Google Patents

Processo para preparar inibidores de trombina de peso constante, composto, droga, e, uso de um composto

Info

Publication number
BR0010440A
BR0010440A BR0010440-0A BR0010440A BR0010440A BR 0010440 A BR0010440 A BR 0010440A BR 0010440 A BR0010440 A BR 0010440A BR 0010440 A BR0010440 A BR 0010440A
Authority
BR
Brazil
Prior art keywords
compound
constant weight
thrombin inhibitors
drug
preparing thrombin
Prior art date
Application number
BR0010440-0A
Other languages
English (en)
Inventor
Bernd Schofer
Guido Harms
Hermann Ascherl
Georg Arnold Krei
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR0010440A publication Critical patent/BR0010440A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)

Abstract

"PROCESSO PARA PREPARAR INIBIDORES DE TROMBINA DE PESO CONSTANTE, COMPOSTO, DROGA, E, USO DE UM COMPOSTO". A invenção refere-se a um processo para preparar inibidores de trombina de peso constante da fórmula I: em que n é 0, 1, 2, e tautómeros dos mesmos, em que uma solução aquosa da substância ativa é secada por pulverização.
BR0010440-0A 1999-05-10 2000-05-03 Processo para preparar inibidores de trombina de peso constante, composto, droga, e, uso de um composto BR0010440A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19921346A DE19921346A1 (de) 1999-05-10 1999-05-10 Sprühtrocknung von Thrombininhibitoren
PCT/EP2000/003965 WO2000068254A1 (de) 1999-05-10 2000-05-03 Sprühtrocknung von thrombininhibitoren

Publications (1)

Publication Number Publication Date
BR0010440A true BR0010440A (pt) 2002-02-19

Family

ID=7907478

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010440-0A BR0010440A (pt) 1999-05-10 2000-05-03 Processo para preparar inibidores de trombina de peso constante, composto, droga, e, uso de um composto

Country Status (20)

Country Link
US (1) US6693120B1 (pt)
EP (1) EP1177208A1 (pt)
JP (1) JP2003501349A (pt)
KR (1) KR20020010647A (pt)
CN (1) CN1350545A (pt)
AU (1) AU4560900A (pt)
BG (1) BG106089A (pt)
BR (1) BR0010440A (pt)
CA (1) CA2373068A1 (pt)
CZ (1) CZ20014039A3 (pt)
DE (1) DE19921346A1 (pt)
HK (1) HK1045530A1 (pt)
HU (1) HUP0201286A3 (pt)
IL (1) IL146361A0 (pt)
NO (1) NO20015465L (pt)
PL (1) PL351668A1 (pt)
RU (1) RU2001133346A (pt)
SK (1) SK16172001A3 (pt)
TR (1) TR200103246T2 (pt)
WO (1) WO2000068254A1 (pt)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE261162C (pt)
GB956944A (en) 1962-06-22 1964-04-29 Commercial Solvents Corp Improved method of preparing free flowing materials containing chloine chloride
FR2097079A1 (en) 1970-07-31 1972-03-03 Melle Usine De Aluminium n-acetyl glycinates - by spray-drying of solns
DE3173600D1 (en) * 1980-05-20 1986-03-13 Mallinckrodt Inc Spray dried n-acetyl-p-aminophenol compositions and method for manufacture thereof
DD261162A1 (de) * 1986-03-11 1988-10-19 Jenapharm Veb Verfahren zur isolierung von pharmazeutisch verwendbarem cloxacillin-natrium
US4861591A (en) 1987-11-18 1989-08-29 American Home Products Corporation Formulations for hygroscopic pharmaceuticals
DE4315878A1 (de) 1993-05-12 1994-11-17 Basf Ag Magnesiumsalz von 3-Isopropyl-2,1,3-benzothiadiazin-4-on-2,2 -dioxid, Verfahren zu seiner Herstellung und seine Verwendung zur Bekämpfung von unerwünschtem Pflanzenwuchs
NZ302649A (en) 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
EP1054017B1 (de) * 1999-05-10 2004-10-13 Abbott GmbH & Co. KG Salze von Thrombininhibitoren

Also Published As

Publication number Publication date
HUP0201286A3 (en) 2002-11-28
TR200103246T2 (tr) 2002-04-22
HK1045530A1 (zh) 2002-11-29
SK16172001A3 (sk) 2002-06-04
WO2000068254A1 (de) 2000-11-16
KR20020010647A (ko) 2002-02-04
BG106089A (en) 2002-06-28
EP1177208A1 (de) 2002-02-06
PL351668A1 (en) 2003-05-19
HUP0201286A2 (en) 2002-09-28
NO20015465D0 (no) 2001-11-08
CA2373068A1 (en) 2000-11-16
JP2003501349A (ja) 2003-01-14
IL146361A0 (en) 2002-07-25
NO20015465L (no) 2001-11-09
AU4560900A (en) 2000-11-21
US6693120B1 (en) 2004-02-17
RU2001133346A (ru) 2004-01-20
CZ20014039A3 (cs) 2003-02-12
DE19921346A1 (de) 2000-11-16
CN1350545A (zh) 2002-05-22

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A, 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007.