BR0007563A - Imunotoxinas anti-cd3 e seus usos terapêuticos - Google Patents

Imunotoxinas anti-cd3 e seus usos terapêuticos

Info

Publication number
BR0007563A
BR0007563A BR0007563-9A BR0007563A BR0007563A BR 0007563 A BR0007563 A BR 0007563A BR 0007563 A BR0007563 A BR 0007563A BR 0007563 A BR0007563 A BR 0007563A
Authority
BR
Brazil
Prior art keywords
immunotoxins
pharmaceutically acceptable
therapeutic uses
treatment
acceptable salts
Prior art date
Application number
BR0007563-9A
Other languages
English (en)
Inventor
Mary Ellen Digan
Philip Lake
Richard Michael Wright
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0007563A publication Critical patent/BR0007563A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: "IMUNOTOXINAS ANTI-CD3 E SEUS USOS TERAPêUTICOS". Polipeptídeos de imunotoxina recombinante são descritos compreendendo um domínio de ligação a CD3 e um mutante de exotoxina de Pseudomonas, e em particular, compreendendo uma cadeia simples (sc) Fv como a porção de ligação CD3. Uma espécie preferida da invenção compreende scFv(UCHT-1)-PE38. Também são descritos métodos para a preparação das ditas imunotoxinas; imunotoxinas funcionalmente equivalentes que são intermediários na preparação das imunotoxinas da invenção, bem como intermediários de polinucleotídeo e oligonucleotídeo; métodos para a prevenção e/ou tratamento de rejeição de transplante e indução de tolerância, bem como tratamento de distúrbios autoimunes e outros imunes, usando a imunotoxina ou seus sais farmaceuticamente aceitáveis; e composições farmacêuticas compreendendo as imunotoxinas ou seus sais farmaceuticamente aceitáveis.
BR0007563-9A 1999-01-15 2000-01-13 Imunotoxinas anti-cd3 e seus usos terapêuticos BR0007563A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23244599A 1999-01-15 1999-01-15
US23696899A 1999-01-25 1999-01-25
US41413499A 1999-10-07 1999-10-07
US09/480,236 US20020142000A1 (en) 1999-01-15 2000-01-10 Anti-CD3 immunotoxins and therapeutic uses therefor
PCT/EP2000/000245 WO2000041474A2 (en) 1999-01-15 2000-01-13 Anti-cd3 immunotoxins and therapeutic uses therefor

Publications (1)

Publication Number Publication Date
BR0007563A true BR0007563A (pt) 2001-11-06

Family

ID=27499649

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007563-9A BR0007563A (pt) 1999-01-15 2000-01-13 Imunotoxinas anti-cd3 e seus usos terapêuticos

Country Status (8)

Country Link
US (1) US20020142000A1 (pt)
EP (1) EP1141023A2 (pt)
JP (1) JP2002534441A (pt)
CN (1) CN1341124A (pt)
AU (1) AU2437000A (pt)
BR (1) BR0007563A (pt)
CA (1) CA2359365A1 (pt)
WO (1) WO2000041474A2 (pt)

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Also Published As

Publication number Publication date
WO2000041474A2 (en) 2000-07-20
CA2359365A1 (en) 2000-07-20
EP1141023A2 (en) 2001-10-10
AU2437000A (en) 2000-08-01
US20020142000A1 (en) 2002-10-03
JP2002534441A (ja) 2002-10-15
CN1341124A (zh) 2002-03-20
WO2000041474A3 (en) 2001-07-19

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