BR0007394A - Método de usar quinoxalinas de(2-imidazolin-2-ilamino) no tratamento de lesãonervosa - Google Patents

Método de usar quinoxalinas de(2-imidazolin-2-ilamino) no tratamento de lesãonervosa

Info

Publication number
BR0007394A
BR0007394A BR0007394-6A BR0007394A BR0007394A BR 0007394 A BR0007394 A BR 0007394A BR 0007394 A BR0007394 A BR 0007394A BR 0007394 A BR0007394 A BR 0007394A
Authority
BR
Brazil
Prior art keywords
imidazolin
ylamino
quinoxalines
treatment
hydrogen
Prior art date
Application number
BR0007394-6A
Other languages
English (en)
Inventor
Larry A Wheeler
Elizabeth Woldemussie
Ronald K Lai
Original Assignee
Allergan Sales Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22843255&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0007394(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Sales Inc filed Critical Allergan Sales Inc
Publication of BR0007394A publication Critical patent/BR0007394A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "MéTODO DE USAR QUINOXALINAS DE(2-IMIDAZOLIN-2-ILAMINO) NO TRATAMENTO DE LESãONERVOSA". A presente invenção refere-se a um método deproteger as células nervosas ópticas ou retinais de um mamíferoque compreende administrar ao dito mamífero que sofre ou emrisco de sofrer de uma ação nociva nas ditas células nervosas umaquantidade eficaz de um composto da fórmula I para inibir ou evitardano ou morte de célula nervosa em que o grupo2-imidazolin-2-ilamino está ou na posição 5 ou 6 dos núcleos dequinoxalina; x, y e z estão em qualquer uma das posições restantes5, 6, 7 ou 8 e são selecionados de hidrogênio, halogênio, alquilainferior, alcóxi inferior ou trifluorometila; e R é um substituinteopcional ou na posição 2 ou 3 dos núcleos de quinoxalina e podeser hidrogênio, alquila inferior ou alcóxi inferior, ou seus saisfarmaceuticamente aceitáveis e misturas destes. Tal ação nocivapode resultar de neuropatia óptica glaucomatosa; degeneraçãomacular relacionada com a idade ou retinite pigmentosa.
BR0007394-6A 1999-01-04 2000-01-04 Método de usar quinoxalinas de(2-imidazolin-2-ilamino) no tratamento de lesãonervosa BR0007394A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/225,036 US6194415B1 (en) 1995-06-28 1999-01-04 Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
PCT/US2000/000068 WO2000040245A1 (en) 1999-01-04 2000-01-04 Method of using (2-imidazolin-2-ylamino) quinoxalines in treating neural injury

Publications (1)

Publication Number Publication Date
BR0007394A true BR0007394A (pt) 2001-10-30

Family

ID=22843255

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007394-6A BR0007394A (pt) 1999-01-04 2000-01-04 Método de usar quinoxalinas de(2-imidazolin-2-ilamino) no tratamento de lesãonervosa

Country Status (12)

Country Link
US (6) US6194415B1 (pt)
EP (1) EP1146877B1 (pt)
JP (2) JP2002534387A (pt)
CN (1) CN1205932C (pt)
AT (1) ATE311187T1 (pt)
AU (1) AU762641B2 (pt)
BR (1) BR0007394A (pt)
CA (1) CA2357014C (pt)
DE (1) DE60024407T2 (pt)
ES (1) ES2251968T3 (pt)
HK (1) HK1040938B (pt)
WO (1) WO2000040245A1 (pt)

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Also Published As

Publication number Publication date
EP1146877B1 (en) 2005-11-30
US6194415B1 (en) 2001-02-27
AU762641B2 (en) 2003-07-03
CN1205932C (zh) 2005-06-15
DE60024407D1 (de) 2006-01-05
CA2357014C (en) 2009-08-04
US20010046998A1 (en) 2001-11-29
HK1040938B (zh) 2006-05-12
US20020111357A1 (en) 2002-08-15
JP2007291129A (ja) 2007-11-08
ATE311187T1 (de) 2005-12-15
JP2002534387A (ja) 2002-10-15
US8455492B2 (en) 2013-06-04
WO2000040245A1 (en) 2000-07-13
US6465464B2 (en) 2002-10-15
CN1335773A (zh) 2002-02-13
DE60024407T2 (de) 2006-08-10
CA2357014A1 (en) 2000-07-13
US6248741B1 (en) 2001-06-19
EP1146877A1 (en) 2001-10-24
AU2846000A (en) 2000-07-24
US20020183328A1 (en) 2002-12-05
HK1040938A1 (en) 2002-06-28
ES2251968T3 (es) 2006-05-16
US20060089361A1 (en) 2006-04-27

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B12B Appeal against refusal [chapter 12.2 patent gazette]