BG64289B1 - М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а - Google Patents

М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а Download PDF

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Publication number
BG64289B1
BG64289B1 BG104696A BG10469600A BG64289B1 BG 64289 B1 BG64289 B1 BG 64289B1 BG 104696 A BG104696 A BG 104696A BG 10469600 A BG10469600 A BG 10469600A BG 64289 B1 BG64289 B1 BG 64289B1
Authority
BG
Bulgaria
Prior art keywords
water
hmg
coa reductase
organic solvent
reductase inhibitor
Prior art date
Application number
BG104696A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104696A (en
Inventor
Zlatko Pflaum
Dusan Milivojevic
David Senica
Original Assignee
Lek Pharmaceutical And Chemical Company D.D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64289(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Pharmaceutical And Chemical Company D.D filed Critical Lek Pharmaceutical And Chemical Company D.D
Publication of BG104696A publication Critical patent/BG104696A/xx
Publication of BG64289B1 publication Critical patent/BG64289B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
BG104696A 1998-02-18 2000-08-17 М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а BG64289B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800046A SI9800046A (sl) 1998-02-18 1998-02-18 Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
PCT/IB1999/000808 WO1999042601A1 (fr) 1998-02-18 1999-02-17 PROCEDE D'OBTENTION D'INHIBITEURS TRES PURS DE LA HMG-CoA REDUCTASE

Publications (2)

Publication Number Publication Date
BG104696A BG104696A (en) 2001-07-31
BG64289B1 true BG64289B1 (bg) 2004-08-31

Family

ID=20432203

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104696A BG64289B1 (bg) 1998-02-18 2000-08-17 М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а

Country Status (21)

Country Link
US (1) US6825015B1 (fr)
EP (1) EP1054993B1 (fr)
JP (2) JP2002504345A (fr)
KR (1) KR100582620B1 (fr)
CN (1) CN1206363C (fr)
AT (1) ATE296357T1 (fr)
AU (1) AU743619B2 (fr)
BG (1) BG64289B1 (fr)
CA (1) CA2321052A1 (fr)
CZ (1) CZ297093B6 (fr)
DE (1) DE69925459T2 (fr)
HR (1) HRP20000541A2 (fr)
HU (1) HUP0100820A3 (fr)
IL (1) IL137782A0 (fr)
PL (1) PL193510B1 (fr)
RO (1) RO120922B1 (fr)
RU (1) RU2235130C2 (fr)
SI (2) SI9800046A (fr)
SK (1) SK285074B6 (fr)
WO (1) WO1999042601A1 (fr)
YU (1) YU50100A (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444452B1 (en) * 1999-11-30 2002-09-03 Biogal Gyogyszergyar Rt. Process for recovering statin compounds from a fermentation broth
KR20020062340A (ko) 1999-12-14 2002-07-25 비오갈 기오기스제르갸르 알티. 신규 형태의 프라바스타틴 나트륨
AU3654301A (en) * 2000-02-24 2001-09-03 Biogal Gyogyszergyar Method of purifying a fermentation broth
HUP0301214A2 (hu) * 2000-03-03 2003-08-28 Plus Chemicals S.A. Tisztítási eljárás csökkentett dimer szennyező tartalmú lovastatin és simvastatin előállítására
IN192861B (fr) * 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
US6936731B2 (en) * 2000-10-05 2005-08-30 TEVA Gyógyszergyár Részvénytársaság Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
JP2007512366A (ja) 2003-11-24 2007-05-17 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ プラバスタチンの精製方法
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
CN102384955B (zh) * 2010-09-01 2014-04-30 北京北大维信生物科技有限公司 人体血浆中HMG－CoA还原酶抑制剂的定量分析方法
RU2585233C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Промышленный способ получения компактина
RU2585234C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Способ получения компактина

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4294846A (en) * 1979-09-21 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and products of preparation
PT85109A (en) 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
DK0784605T3 (da) 1995-08-03 2000-07-31 Dsm Nv Selektiv fremgangsmåde til deacyleringen af acylforbindelser
AU7271696A (en) * 1995-12-06 1997-06-27 Antibiotic Co Method of production of lovastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására

Also Published As

Publication number Publication date
RU2235130C2 (ru) 2004-08-27
PL193510B1 (pl) 2007-02-28
US6825015B1 (en) 2004-11-30
EP1054993B1 (fr) 2005-05-25
KR20010041024A (ko) 2001-05-15
HUP0100820A2 (hu) 2001-08-28
SI1054993T1 (en) 2005-10-31
SK285074B6 (sk) 2006-05-04
SK11852000A3 (sk) 2001-05-10
YU50100A (sh) 2003-07-07
CZ20002856A3 (cs) 2000-11-15
PL342513A1 (en) 2001-06-18
IL137782A0 (en) 2001-10-31
HRP20000541A2 (en) 2001-12-31
CA2321052A1 (fr) 1999-08-26
AU3438499A (en) 1999-09-06
CN1291238A (zh) 2001-04-11
RO120922B1 (ro) 2006-09-29
JP2005110693A (ja) 2005-04-28
ATE296357T1 (de) 2005-06-15
AU743619B2 (en) 2002-01-31
DE69925459T2 (de) 2006-04-27
KR100582620B1 (ko) 2006-05-23
BG104696A (en) 2001-07-31
HUP0100820A3 (en) 2003-07-28
CZ297093B6 (cs) 2006-09-13
SI9800046A (sl) 1999-08-31
EP1054993A1 (fr) 2000-11-29
DE69925459D1 (de) 2005-06-30
JP2002504345A (ja) 2002-02-12
CN1206363C (zh) 2005-06-15
WO1999042601A1 (fr) 1999-08-26

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