BG61977B1 - Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти - Google Patents
Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти Download PDFInfo
- Publication number
- BG61977B1 BG61977B1 BG101715A BG10171597A BG61977B1 BG 61977 B1 BG61977 B1 BG 61977B1 BG 101715 A BG101715 A BG 101715A BG 10171597 A BG10171597 A BG 10171597A BG 61977 B1 BG61977 B1 BG 61977B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- methyl
- piperidine
- furo
- carbonyl
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426029.6A GB9426029D0 (en) | 1994-12-22 | 1994-12-22 | Novel compounds |
| GBGB9512920.1A GB9512920D0 (en) | 1995-06-24 | 1995-06-24 | Novel compounds |
| PCT/EP1995/004889 WO1996019477A1 (en) | 1994-12-22 | 1995-12-06 | Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG101715A BG101715A (en) | 1998-02-27 |
| BG61977B1 true BG61977B1 (bg) | 1998-11-30 |
Family
ID=26306239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG101715A BG61977B1 (bg) | 1994-12-22 | 1997-07-01 | Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5972951A (ja) |
| EP (1) | EP0799226B1 (ja) |
| JP (1) | JPH10510821A (ja) |
| CN (1) | CN1175256A (ja) |
| AP (1) | AP757A (ja) |
| AR (1) | AR002011A1 (ja) |
| AT (1) | ATE199085T1 (ja) |
| AU (1) | AU697361B2 (ja) |
| BG (1) | BG61977B1 (ja) |
| BR (1) | BR9510419A (ja) |
| CA (1) | CA2208244A1 (ja) |
| CZ (1) | CZ192397A3 (ja) |
| DE (1) | DE69520075T2 (ja) |
| DZ (1) | DZ1957A1 (ja) |
| ES (1) | ES2153907T3 (ja) |
| FI (1) | FI972583A (ja) |
| HU (1) | HUT77650A (ja) |
| IL (1) | IL116486A0 (ja) |
| MA (1) | MA23753A1 (ja) |
| MX (1) | MX9704777A (ja) |
| NO (1) | NO972910L (ja) |
| NZ (1) | NZ298036A (ja) |
| OA (1) | OA10610A (ja) |
| PL (1) | PL321048A1 (ja) |
| SK (1) | SK80297A3 (ja) |
| TR (1) | TR199501597A2 (ja) |
| WO (1) | WO1996019477A1 (ja) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9519033D0 (en) * | 1995-09-18 | 1995-11-15 | Smithkline Beecham Plc | Treatment |
| EP0861257A1 (en) * | 1995-11-08 | 1998-09-02 | Smithkline Beecham Plc | Spiro piperidine derivatives as 5mt receptor antagonists |
| GB9522845D0 (en) * | 1995-11-08 | 1996-01-10 | Smithkline Beecham Plc | Novel compounds |
| US5972979A (en) * | 1995-11-22 | 1999-10-26 | Smithkline Beecham P.L.C. | Tricyclic spiro compounds as 5HT1D receptor antagonists |
| GB9605883D0 (en) * | 1996-03-20 | 1996-05-22 | Smithkline Beecham Plc | Novel compounds |
| GB9606396D0 (en) * | 1996-03-27 | 1996-06-05 | Smithkline Beecham Plc | Novel compounds |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| FR2761069A1 (fr) * | 1997-03-20 | 1998-09-25 | Pf Medicament | Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments |
| CA2347095A1 (en) * | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing condensed heterocyclic derivatives, their production and agent |
| DE10051981A1 (de) | 2000-10-20 | 2002-05-02 | Bayer Ag | Substituierte Phenyluracile |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| SG2009082793A (en) * | 2003-06-03 | 2015-03-30 | Rib X Pharmaceuticals Inc | Biaryl heterocyclic compounds and methods of making and using the same |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| EP1975149B1 (en) | 2005-12-26 | 2012-02-15 | Nissan Chemical Industries, Ltd. | 1,3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof |
| WO2008140895A1 (en) | 2007-04-20 | 2008-11-20 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| EP2532643A1 (en) | 2007-06-08 | 2012-12-12 | MannKind Corporation | IRE-1A Inhibitors |
| US8952175B2 (en) | 2007-06-27 | 2015-02-10 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound |
| CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| EP2488531B1 (en) | 2009-10-14 | 2014-03-26 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
| WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
| MX2020008015A (es) | 2018-01-31 | 2020-10-16 | Deciphera Pharmaceuticals Llc | Terapia de combinación para el tratamiento de la mastocitosis. |
| WO2019152711A1 (en) | 2018-01-31 | 2019-08-08 | Diciphera Pharmaceuticals Llc. | Combination therapy for the treatment of gastrointestinal stromal tumors |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| AU2020329956B2 (en) | 2019-08-12 | 2023-11-16 | Deciphera Pharmaceuticals, Llc. | Ripretinib for treating gastrointestinal stromal tumors |
| TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| CN115243681B (zh) | 2019-12-30 | 2024-08-16 | 德西费拉制药有限责任公司 | 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物 |
| FI4084778T3 (fi) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0533268T3 (da) | 1991-09-18 | 2001-12-03 | Glaxo Group Ltd | Benzanilidderivater som 5HT-1D antagonister |
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
-
1995
- 1995-12-06 DE DE69520075T patent/DE69520075T2/de not_active Expired - Fee Related
- 1995-12-06 US US08/849,932 patent/US5972951A/en not_active Expired - Fee Related
- 1995-12-06 CN CN95197616A patent/CN1175256A/zh active Pending
- 1995-12-06 AP APAP/P/1997/001006A patent/AP757A/en active
- 1995-12-06 PL PL95321048A patent/PL321048A1/xx unknown
- 1995-12-06 ES ES95942116T patent/ES2153907T3/es not_active Expired - Lifetime
- 1995-12-06 JP JP8519477A patent/JPH10510821A/ja active Pending
- 1995-12-06 WO PCT/EP1995/004889 patent/WO1996019477A1/en not_active Application Discontinuation
- 1995-12-06 CA CA002208244A patent/CA2208244A1/en not_active Abandoned
- 1995-12-06 BR BR9510419A patent/BR9510419A/pt not_active Application Discontinuation
- 1995-12-06 SK SK802-97A patent/SK80297A3/sk unknown
- 1995-12-06 EP EP95942116A patent/EP0799226B1/en not_active Expired - Lifetime
- 1995-12-06 HU HU9800158A patent/HUT77650A/hu unknown
- 1995-12-06 MX MX9704777A patent/MX9704777A/es unknown
- 1995-12-06 AT AT95942116T patent/ATE199085T1/de active
- 1995-12-06 AU AU43433/96A patent/AU697361B2/en not_active Ceased
- 1995-12-06 CZ CZ971923A patent/CZ192397A3/cs unknown
- 1995-12-06 NZ NZ298036A patent/NZ298036A/en unknown
- 1995-12-19 AR ARP950100629A patent/AR002011A1/es unknown
- 1995-12-19 TR TR95/01597A patent/TR199501597A2/xx unknown
- 1995-12-20 MA MA24106A patent/MA23753A1/fr unknown
- 1995-12-20 DZ DZ950140A patent/DZ1957A1/fr active
- 1995-12-21 IL IL11648695A patent/IL116486A0/xx unknown
-
1997
- 1997-06-17 FI FI972583A patent/FI972583A/fi unknown
- 1997-06-20 NO NO972910A patent/NO972910L/no unknown
- 1997-06-20 OA OA70033A patent/OA10610A/en unknown
- 1997-07-01 BG BG101715A patent/BG61977B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI972583A0 (fi) | 1997-06-17 |
| IL116486A0 (en) | 1997-08-14 |
| AU697361B2 (en) | 1998-10-01 |
| EP0799226A1 (en) | 1997-10-08 |
| ES2153907T3 (es) | 2001-03-16 |
| ATE199085T1 (de) | 2001-02-15 |
| AP757A (en) | 1999-09-06 |
| BR9510419A (pt) | 1998-05-19 |
| DE69520075D1 (de) | 2001-03-15 |
| HUT77650A (hu) | 1998-07-28 |
| CN1175256A (zh) | 1998-03-04 |
| SK80297A3 (en) | 1998-12-02 |
| BG101715A (en) | 1998-02-27 |
| OA10610A (en) | 2002-09-06 |
| TR199501597A2 (tr) | 1996-07-21 |
| AU4343396A (en) | 1996-07-10 |
| JPH10510821A (ja) | 1998-10-20 |
| US5972951A (en) | 1999-10-26 |
| WO1996019477A1 (en) | 1996-06-27 |
| MA23753A1 (fr) | 1996-07-01 |
| AP9701006A0 (en) | 1997-07-31 |
| CA2208244A1 (en) | 1996-06-27 |
| NO972910D0 (no) | 1997-06-20 |
| NO972910L (no) | 1997-08-14 |
| FI972583A (fi) | 1997-08-19 |
| DZ1957A1 (fr) | 2002-02-17 |
| NZ298036A (en) | 1998-11-25 |
| AR002011A1 (es) | 1998-01-07 |
| PL321048A1 (en) | 1997-11-24 |
| EP0799226B1 (en) | 2001-02-07 |
| CZ192397A3 (en) | 1997-09-17 |
| MX9704777A (es) | 1997-10-31 |
| DE69520075T2 (de) | 2001-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG61977B1 (bg) | Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти | |
| KR102449652B1 (ko) | Rock의 억제제로서의 스피로-융합 시클릭 우레아 | |
| KR101050700B1 (ko) | 칼슘 수용체 조절 화합물 및 이의 용도 | |
| AU724076B2 (en) | Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAalpha5 receptor subtype | |
| JP2690282B2 (ja) | イミダゾジアゼピン | |
| WO1996011929A1 (en) | Biheteroaryl-carbonyl and carboxamide derivatives with 5ht 2c/2b antagonists activity | |
| JP2008101012A (ja) | 三環式ベンゾアゼピンバソプレッシンアンタゴニスト類 | |
| SK85590A3 (en) | Indolylsubstituted pyrroles, their use as therapeutically effective agent | |
| JP2002532501A (ja) | キノリン誘導体 | |
| MXPA02012895A (es) | Derivados de pirazol condensado con 1-(heteroaril-fenil) como inhibidores del factor xa. | |
| AU2006298164A1 (en) | Novel fused pyrrole derivative | |
| EP1003738B1 (en) | Bicyclic compounds as ligands for 5-ht1 receptors | |
| CA3081424A1 (en) | Spirocyclic compounds as farnesoid x receptor modulators | |
| OA10601A (en) | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclicring | |
| JP4141499B2 (ja) | 縮合した２，３―ベンゾジアゼピン誘導体及びａｍｐａ―レセプター抑制剤としての使用 | |
| WO2000006575A2 (en) | Azabicyclic compounds | |
| EP1233965A1 (en) | Isoquinoline and quinazoline derivatives for the treatment of cns disorders | |
| AU664912B2 (en) | Novel 3-oxadiazolyl-1,6-naphthyridine derivatives | |
| US6166034A (en) | Spiro piperidine derivatives as 5HT1D receptor antagonists | |
| US5972979A (en) | Tricyclic spiro compounds as 5HT1D receptor antagonists | |
| CN119176808A (zh) | 一种glp-1激动剂及其制备方法和应用 | |
| WO2003016311A1 (en) | Tricyclic pyridin-2-one analogues as ligands for gaba-a receptors |