BG45387A3 - Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинил - Google Patents
Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинилInfo
- Publication number
- BG45387A3 BG45387A3 BG076699A BG7669983A BG45387A3 BG 45387 A3 BG45387 A3 BG 45387A3 BG 076699 A BG076699 A BG 076699A BG 7669983 A BG7669983 A BG 7669983A BG 45387 A3 BG45387 A3 BG 45387A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- sorbinyl
- fluoro
- mixture
- production
- give
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000008929 regeneration Effects 0.000 title 1
- 238000011069 regeneration method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- SWBBIJZMIGAZHW-UHFFFAOYSA-N 6-fluoro-2,3-dihydrochromen-4-one Chemical compound O1CCC(=O)C2=CC(F)=CC=C21 SWBBIJZMIGAZHW-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-Chlorosuccinimide Substances ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract 1
- LXANPKRCLVQAOG-NSHDSACASA-N sorbinil Chemical compound C12=CC(F)=CC=C2OCC[C@@]21NC(=O)NC2=O LXANPKRCLVQAOG-NSHDSACASA-N 0.000 abstract 1
- 229950004311 sorbinil Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/440,657 US4431828A (en) | 1982-11-10 | 1982-11-10 | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG45387A3 true BG45387A3 (bg) | 1989-05-15 |
Family
ID=23749651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG076699A BG45387A3 (bg) | 1982-11-10 | 1983-11-09 | Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинил |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4431828A (xx) |
| EP (1) | EP0111387B1 (xx) |
| BG (1) | BG45387A3 (xx) |
| CA (1) | CA1181754A (xx) |
| DE (1) | DE3362952D1 (xx) |
| HK (1) | HK99587A (xx) |
| HU (1) | HU191160B (xx) |
| IE (1) | IE56257B1 (xx) |
| MY (1) | MY8700730A (xx) |
| PH (1) | PH18265A (xx) |
| PL (1) | PL142777B1 (xx) |
| SG (1) | SG69887G (xx) |
| SU (1) | SU1240358A3 (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4620019A (en) * | 1984-08-23 | 1986-10-28 | Pfizer Inc. | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil |
| US4551542A (en) * | 1984-09-26 | 1985-11-05 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid |
| US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
| US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
| US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
| US8579985B2 (en) | 2006-12-07 | 2013-11-12 | Ihip Surgical, Llc | Method and apparatus for hip replacement |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
| US4286098A (en) * | 1980-03-28 | 1981-08-25 | Pfizer Inc. | Process for the preparation of chiral hydantoins |
-
1982
- 1982-11-10 US US06/440,657 patent/US4431828A/en not_active Expired - Fee Related
-
1983
- 1983-11-03 DE DE8383306689T patent/DE3362952D1/de not_active Expired
- 1983-11-03 EP EP83306689A patent/EP0111387B1/en not_active Expired
- 1983-11-08 CA CA000440673A patent/CA1181754A/en not_active Expired
- 1983-11-08 PL PL1983250370A patent/PL142777B1/pl unknown
- 1983-11-09 HU HU842970A patent/HU191160B/hu not_active IP Right Cessation
- 1983-11-09 PH PH29805A patent/PH18265A/en unknown
- 1983-11-09 IE IE2620/83A patent/IE56257B1/en not_active IP Right Cessation
- 1983-11-09 BG BG076699A patent/BG45387A3/xx unknown
-
1984
- 1984-07-02 SU SU843757904A patent/SU1240358A3/ru active
-
1987
- 1987-08-27 SG SG698/87A patent/SG69887G/en unknown
- 1987-12-24 HK HK995/87A patent/HK99587A/xx unknown
- 1987-12-30 MY MY730/87A patent/MY8700730A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4431828A (en) | 1984-02-14 |
| IE832620L (en) | 1984-05-10 |
| EP0111387B1 (en) | 1986-04-09 |
| CA1181754A (en) | 1985-01-29 |
| EP0111387A1 (en) | 1984-06-20 |
| HUT36110A (en) | 1985-08-28 |
| SG69887G (en) | 1988-02-19 |
| MY8700730A (en) | 1987-12-31 |
| SU1240358A3 (ru) | 1986-06-23 |
| DE3362952D1 (en) | 1986-05-15 |
| PH18265A (en) | 1985-05-14 |
| IE56257B1 (en) | 1991-06-05 |
| PL142777B1 (en) | 1987-11-30 |
| PL250370A1 (en) | 1985-06-04 |
| HK99587A (en) | 1987-12-31 |
| HU191160B (en) | 1987-01-28 |
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