BG45387A3 - Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинил - Google Patents

Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинил

Info

Publication number
BG45387A3
BG45387A3 BG076699A BG7669983A BG45387A3 BG 45387 A3 BG45387 A3 BG 45387A3 BG 076699 A BG076699 A BG 076699A BG 7669983 A BG7669983 A BG 7669983A BG 45387 A3 BG45387 A3 BG 45387A3
Authority
BG
Bulgaria
Prior art keywords
sorbinyl
fluoro
mixture
production
give
Prior art date
Application number
BG076699A
Other languages
English (en)
Inventor
Berkeley Cuejun.
Philip Hammen
Stephen MASSETT
Bernard Moore
Robert Sysko
Original Assignee
Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Publication of BG45387A3 publication Critical patent/BG45387A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Методът намира приложение за получаване на допълнителни количества 6флуор-4хроманон, който е междинен продукт при синтеза на сорбинил. Като суровини за регистриране на съединението се използват отпадъщите при производството на сорбинил странични продукти, като rили rs-6флуорспиро/хроман-4, 4-имидазолидин/2',5' -дион:r или смес от r и rs-6-6 флуор-4урендохроман-4карбонова киселина, или техните катионни соли с оптически активен амин, като d-(+)-(1фенил/амин или l-(-)-ефедрин, като се подлагат на хидролиза с неорганична основа във водна среда. Полученото междинно съединение се разлага във вода с хлориращо средство-n-хлорсукцинимид или натриев хипохлорид, до получаване на смес от 6флуор-4-хроманон и 6-флуор-4-хлорминхроманон. Сместа се хидрира каталитично до получаване на желаното съединение, което е в подходяща форма за рециклиране до получаване на сорбинил. 15 претенции
BG076699A 1982-11-10 1983-11-09 Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинил BG45387A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/440,657 US4431828A (en) 1982-11-10 1982-11-10 Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil

Publications (1)

Publication Number Publication Date
BG45387A3 true BG45387A3 (bg) 1989-05-15

Family

ID=23749651

Family Applications (1)

Application Number Title Priority Date Filing Date
BG076699A BG45387A3 (bg) 1982-11-10 1983-11-09 Метод за регенериране на 6-флуор-4-хроманон при производство на сорбинил

Country Status (13)

Country Link
US (1) US4431828A (bg)
EP (1) EP0111387B1 (bg)
BG (1) BG45387A3 (bg)
CA (1) CA1181754A (bg)
DE (1) DE3362952D1 (bg)
HK (1) HK99587A (bg)
HU (1) HU191160B (bg)
IE (1) IE56257B1 (bg)
MY (1) MY8700730A (bg)
PH (1) PH18265A (bg)
PL (1) PL142777B1 (bg)
SG (1) SG69887G (bg)
SU (1) SU1240358A3 (bg)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620019A (en) * 1984-08-23 1986-10-28 Pfizer Inc. S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US8579985B2 (en) 2006-12-07 2013-11-12 Ihip Surgical, Llc Method and apparatus for hip replacement

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins

Also Published As

Publication number Publication date
US4431828A (en) 1984-02-14
IE832620L (en) 1984-05-10
EP0111387B1 (en) 1986-04-09
CA1181754A (en) 1985-01-29
EP0111387A1 (en) 1984-06-20
HUT36110A (en) 1985-08-28
SG69887G (en) 1988-02-19
MY8700730A (en) 1987-12-31
SU1240358A3 (ru) 1986-06-23
DE3362952D1 (en) 1986-05-15
PH18265A (en) 1985-05-14
IE56257B1 (en) 1991-06-05
PL142777B1 (en) 1987-11-30
PL250370A1 (en) 1985-06-04
HK99587A (en) 1987-12-31
HU191160B (en) 1987-01-28

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