BG106937A - Нови индолови производни - Google Patents

Нови индолови производни

Info

Publication number
BG106937A
BG106937A BG106937A BG10693702A BG106937A BG 106937 A BG106937 A BG 106937A BG 106937 A BG106937 A BG 106937A BG 10693702 A BG10693702 A BG 10693702A BG 106937 A BG106937 A BG 106937A
Authority
BG
Bulgaria
Prior art keywords
indole derivatives
novel indole
novel
compounds
5ht1a
Prior art date
Application number
BG106937A
Other languages
English (en)
Inventor
Thomas Ruhland
- JENSEN Christian KROG
Mario Rottlaender
Gitte Mikkelsen
Kim Andersen
Ejner Moltzen
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of BG106937A publication Critical patent/BG106937A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретението се отнася до съединения с формула, в която Х означава О или S, а n има стойност 2, 3,4, 5, 6, 7, 8, 9 или 10, m - 2 или 3, Y представлява N, C или СН, пунктираната линия е евентуална връзка и значенията R1, R1', R2, R3, R4, R5, R6, R7, R8, R10, R11 и R12 са посочени в описанието. Съединенията са 5-НТ1А-рецепторни лиганди.
BG106937A 1999-12-30 2002-07-22 Нови индолови производни BG106937A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901889 1999-12-30
PCT/DK2000/000742 WO2001049680A1 (en) 1999-12-30 2000-12-29 Novel indole derivatives

Publications (1)

Publication Number Publication Date
BG106937A true BG106937A (bg) 2003-04-30

Family

ID=8108836

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106937A BG106937A (bg) 1999-12-30 2002-07-22 Нови индолови производни

Country Status (23)

Country Link
US (1) US20030050307A1 (bg)
EP (1) EP1246818A1 (bg)
JP (1) JP2003519226A (bg)
KR (1) KR20020063288A (bg)
CN (1) CN1437598A (bg)
AR (1) AR027134A1 (bg)
AU (1) AU2352101A (bg)
BG (1) BG106937A (bg)
BR (1) BR0016955A (bg)
CA (1) CA2395606A1 (bg)
CZ (1) CZ20022489A3 (bg)
EA (1) EA200200727A1 (bg)
HU (1) HUP0203767A3 (bg)
IL (1) IL150336A0 (bg)
IS (1) IS6434A (bg)
MX (1) MXPA02006498A (bg)
NO (1) NO20023148D0 (bg)
NZ (1) NZ519648A (bg)
PL (1) PL355538A1 (bg)
SK (1) SK9452002A3 (bg)
TR (1) TR200201689T2 (bg)
WO (1) WO2001049680A1 (bg)
ZA (1) ZA200204969B (bg)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002048105A2 (en) * 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
UA74651C2 (en) * 2001-06-29 2006-01-16 Lundbeck & Co As H Indole derivatives, a pharmaceutical composition based thereon and use thereof
US9174975B2 (en) 2002-08-22 2015-11-03 Sumitomo Dainippon Pharma Co., Ltd Remedy for integration dysfunction syndrome
CA2531980C (en) 2003-06-23 2013-09-17 Dainippon Sumitomo Pharma Co., Ltd. Imide derivatives as therapeutic agents for senile dementia
WO2005080976A1 (ja) 2004-02-20 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. 統合失調症の記憶・学習機能障害治療薬のin vivoスクリーニング方法
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
PL395469A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567884B1 (fr) * 1984-07-19 1987-03-06 Roussel Uclaf Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
AU3667899A (en) * 1998-04-29 1999-11-16 American Home Products Corporation Antipsychotic indolyl derivatives

Also Published As

Publication number Publication date
JP2003519226A (ja) 2003-06-17
HUP0203767A2 (hu) 2003-03-28
SK9452002A3 (en) 2002-11-06
CA2395606A1 (en) 2001-07-12
IS6434A (is) 2002-06-19
AR027134A1 (es) 2003-03-12
NO20023148L (no) 2002-06-28
HUP0203767A3 (en) 2004-06-28
EP1246818A1 (en) 2002-10-09
TR200201689T2 (tr) 2002-10-21
AU2352101A (en) 2001-07-16
CN1437598A (zh) 2003-08-20
BR0016955A (pt) 2003-04-29
EA200200727A1 (ru) 2002-12-26
US20030050307A1 (en) 2003-03-13
KR20020063288A (ko) 2002-08-01
CZ20022489A3 (cs) 2002-10-16
NO20023148D0 (no) 2002-06-28
ZA200204969B (en) 2003-09-22
IL150336A0 (en) 2002-12-01
PL355538A1 (en) 2004-05-04
NZ519648A (en) 2004-05-28
WO2001049680A1 (en) 2001-07-12
MXPA02006498A (es) 2002-11-29

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