BG105345A - Tpl-2/cot kinase and methods of use - Google Patents
Tpl-2/cot kinase and methods of useInfo
- Publication number
- BG105345A BG105345A BG105345A BG10534501A BG105345A BG 105345 A BG105345 A BG 105345A BG 105345 A BG105345 A BG 105345A BG 10534501 A BG10534501 A BG 10534501A BG 105345 A BG105345 A BG 105345A
- Authority
- BG
- Bulgaria
- Prior art keywords
- tpl
- methods
- nfkb
- activation
- cot kinase
- Prior art date
Links
- 102100026907 Mitogen-activated protein kinase kinase kinase 8 Human genes 0.000 title abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 101710164353 Mitogen-activated protein kinase kinase kinase 8 Proteins 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9817930.2A GB9817930D0 (en) | 1998-08-18 | 1998-08-18 | Pathway |
| GBGB9827712.2A GB9827712D0 (en) | 1998-12-16 | 1998-12-16 | Pathway |
| PCT/US1999/018543 WO2000011191A2 (en) | 1998-08-18 | 1999-08-13 | Tpl-2/cot kinase and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG105345A true BG105345A (en) | 2001-12-31 |
Family
ID=26314223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG105345A BG105345A (en) | 1998-08-18 | 2001-03-15 | Tpl-2/cot kinase and methods of use |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20020099169A1 (https=) |
| EP (1) | EP1105501A2 (https=) |
| JP (1) | JP4719831B2 (https=) |
| KR (1) | KR20010085407A (https=) |
| CN (1) | CN1323346A (https=) |
| AU (1) | AU767973B2 (https=) |
| BG (1) | BG105345A (https=) |
| BR (1) | BR9913070A (https=) |
| CA (1) | CA2339036A1 (https=) |
| CZ (1) | CZ2001625A3 (https=) |
| HK (1) | HK1041901A1 (https=) |
| HU (1) | HUP0103797A2 (https=) |
| ID (1) | ID28955A (https=) |
| IL (1) | IL141355A0 (https=) |
| MX (1) | MXPA01001747A (https=) |
| NO (1) | NO20010786L (https=) |
| NZ (1) | NZ510313A (https=) |
| PL (1) | PL347137A1 (https=) |
| RU (1) | RU2001107122A (https=) |
| SK (1) | SK2242001A3 (https=) |
| TR (2) | TR200100624T2 (https=) |
| WO (1) | WO2000011191A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660906B1 (en) | 2000-03-08 | 2003-12-09 | Thomas Jefferson University | Tpl2 transgenic knockout mice |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| GB0402661D0 (en) * | 2004-02-06 | 2004-03-10 | Medical Res Council | TPL2 and its expression |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514505A (en) * | 1995-05-15 | 1996-05-07 | Xerox Corporation | Method for obtaining improved image contrast in migration imaging members |
| UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
-
1999
- 1999-08-13 HU HU0103797A patent/HUP0103797A2/hu unknown
- 1999-08-13 MX MXPA01001747A patent/MXPA01001747A/es unknown
- 1999-08-13 IL IL14135599A patent/IL141355A0/xx unknown
- 1999-08-13 JP JP2000566444A patent/JP4719831B2/ja not_active Expired - Fee Related
- 1999-08-13 PL PL99347137A patent/PL347137A1/xx not_active IP Right Cessation
- 1999-08-13 HK HK02103643.3A patent/HK1041901A1/zh unknown
- 1999-08-13 CN CN99812172A patent/CN1323346A/zh active Pending
- 1999-08-13 AU AU55633/99A patent/AU767973B2/en not_active Ceased
- 1999-08-13 WO PCT/US1999/018543 patent/WO2000011191A2/en not_active Ceased
- 1999-08-13 NZ NZ510313A patent/NZ510313A/en unknown
- 1999-08-13 CZ CZ2001625A patent/CZ2001625A3/cs unknown
- 1999-08-13 EP EP99942203A patent/EP1105501A2/en not_active Withdrawn
- 1999-08-13 SK SK224-2001A patent/SK2242001A3/sk unknown
- 1999-08-13 ID IDW20010645A patent/ID28955A/id unknown
- 1999-08-13 TR TR2001/00624T patent/TR200100624T2/xx unknown
- 1999-08-13 CA CA002339036A patent/CA2339036A1/en not_active Abandoned
- 1999-08-13 KR KR1020017002091A patent/KR20010085407A/ko not_active Abandoned
- 1999-08-13 RU RU2001107122/14A patent/RU2001107122A/ru not_active Application Discontinuation
- 1999-08-13 TR TR2001/03840T patent/TR200103840T2/xx unknown
- 1999-08-13 BR BR9913070-0A patent/BR9913070A/pt not_active IP Right Cessation
- 1999-08-13 US US09/374,579 patent/US20020099169A1/en not_active Abandoned
-
2001
- 2001-02-16 NO NO20010786A patent/NO20010786L/no not_active Application Discontinuation
- 2001-03-15 BG BG105345A patent/BG105345A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9913070A (pt) | 2001-05-08 |
| PL347137A1 (en) | 2002-03-25 |
| KR20010085407A (ko) | 2001-09-07 |
| CN1323346A (zh) | 2001-11-21 |
| ID28955A (id) | 2001-07-19 |
| AU767973B2 (en) | 2003-11-27 |
| WO2000011191A3 (en) | 2000-06-08 |
| HUP0103797A2 (hu) | 2003-10-28 |
| HK1041901A1 (zh) | 2002-07-26 |
| CZ2001625A3 (cs) | 2002-02-13 |
| TR200103840T2 (tr) | 2002-06-21 |
| RU2001107122A (ru) | 2003-04-20 |
| JP2002531058A (ja) | 2002-09-24 |
| TR200100624T2 (tr) | 2001-08-21 |
| NZ510313A (en) | 2003-11-28 |
| EP1105501A2 (en) | 2001-06-13 |
| US20020099169A1 (en) | 2002-07-25 |
| WO2000011191A2 (en) | 2000-03-02 |
| MXPA01001747A (es) | 2003-06-06 |
| IL141355A0 (en) | 2002-03-10 |
| JP4719831B2 (ja) | 2011-07-06 |
| NO20010786D0 (no) | 2001-02-16 |
| SK2242001A3 (en) | 2001-10-08 |
| AU5563399A (en) | 2000-03-14 |
| NO20010786L (no) | 2001-04-17 |
| CA2339036A1 (en) | 2000-03-02 |
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