BG104091A - Сd154 блокадна терапия при трансплантация на тъкан от панкреатични острови - Google Patents

Сd154 блокадна терапия при трансплантация на тъкан от панкреатични острови

Info

Publication number
BG104091A
BG104091A BG104091A BG10409100A BG104091A BG 104091 A BG104091 A BG 104091A BG 104091 A BG104091 A BG 104091A BG 10409100 A BG10409100 A BG 10409100A BG 104091 A BG104091 A BG 104091A
Authority
BG
Bulgaria
Prior art keywords
graft
therapty
isles
blockade
pancreatic
Prior art date
Application number
BG104091A
Other languages
English (en)
Other versions
BG64976B1 (bg
Inventor
Norma Kenyon
Camillo Ricordi
David Thomas
Linda Burkly
Original Assignee
University Of Miami
Biogen Idec Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Miami, Biogen Idec Ma Inc. filed Critical University Of Miami
Publication of BG104091A publication Critical patent/BG104091A/bg
Publication of BG64976B1 publication Critical patent/BG64976B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)

Abstract

Изобретението се отнася до методи и лекарствени препарати за инхибиране отхвърлянето на инсулинпродуцираща тъкан от трансплантиран реципиент, както идо методи и препарати за удължаване преживяванетоили функцията на присадката, за обратимост на отхвърлянето на присадката или възстановяване функцията на увредена присадка и за индуциране имунен толеранс спрямо трансплантирана, инсулинпродуцираща тъкан. Посочените методи и препарати са подходящи за лечение или профилактика на дефекти в метаболитния контрол на глюкозната хомеостаза в кръвта, включително на дефекти, проявени като захарен диабет (DМ).
BG104091A 1997-06-20 2000-01-18 Сd154 блокадна терапия при трансплантация на тъкан от панкреатични острови BG64976B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5026797P 1997-06-20 1997-06-20
US7726598P 1998-03-09 1998-03-09

Publications (2)

Publication Number Publication Date
BG104091A true BG104091A (bg) 2000-10-31
BG64976B1 BG64976B1 (bg) 2006-11-30

Family

ID=26728084

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104091A BG64976B1 (bg) 1997-06-20 2000-01-18 Сd154 блокадна терапия при трансплантация на тъкан от панкреатични острови

Country Status (22)

Country Link
US (2) US20030072754A1 (bg)
EP (1) EP1051191B1 (bg)
JP (1) JP2002506446A (bg)
KR (1) KR100634847B1 (bg)
CN (2) CN1195546C (bg)
AT (1) ATE339966T1 (bg)
AU (1) AU730763B2 (bg)
BG (1) BG64976B1 (bg)
BR (1) BR9810620A (bg)
CA (1) CA2294154A1 (bg)
DE (1) DE69835965T2 (bg)
EA (1) EA002550B1 (bg)
EE (1) EE9900588A (bg)
HK (1) HK1033548A1 (bg)
HU (1) HUP0003160A3 (bg)
IL (1) IL133303A0 (bg)
IS (1) IS5273A (bg)
NO (1) NO996275L (bg)
NZ (1) NZ502052A (bg)
SK (1) SK180299A3 (bg)
TR (1) TR199903142T2 (bg)
WO (1) WO1998058669A2 (bg)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045958A1 (en) * 1998-03-09 1999-09-16 Biogen, Inc. Cd154 blockade therapy for modulation of immune responses to implanted devices
WO2001079555A2 (en) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
CA2410786A1 (en) * 2000-06-02 2001-12-13 Regents Of The University Of Minnesota Immunotherapeutic method to prevent islet cell rejection
KR20030007899A (ko) * 2000-06-09 2003-01-23 브리스톨-마이어스스퀴브컴파니 림프구성 신호의 차단 및 ｌｆａ-1 매개 접착의 차단을통한 세포-매개 면역 반응의 조절 방법
CA2528551A1 (en) * 2003-06-13 2005-01-13 Biogen Idec Ma Inc. Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof
AU2005287406B2 (en) 2004-07-26 2011-08-18 Biogen Ma Inc. Anti-CD154 antibodies
JP2008520235A (ja) * 2004-11-22 2008-06-19 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド インスリンを産生可能な拡大され、かつ再分化した成体島β細胞の集団およびその作製方法
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US8372399B2 (en) 2006-08-31 2013-02-12 Cardiac Pacemakers, Inc. Bispecific antibodies and agents to enhance stem cell homing
US8636995B2 (en) 2006-08-31 2014-01-28 Cardiac Pacemakers, Inc. Methods and devices to regulate stem cell homing
WO2010093467A1 (en) * 2009-02-10 2010-08-19 The Trustees Of Columbia University In The City Of New York Methods for inducing transplantation tolerance
WO2011146395A2 (en) 2010-05-17 2011-11-24 The Board Of Trustees Of The Leland Stanford Junior University Prevention of immunological rejection of transplanted stem cells by leukocyte costimulatory molecule blockade
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10147463B2 (en) 2014-12-10 2018-12-04 Nxp Usa, Inc. Video processing unit and method of buffering a source video stream
US9512229B2 (en) 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
US10986309B2 (en) 2015-06-30 2021-04-20 Nxp Usa, Inc. Video buffering and frame rate doubling device and method
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
WO1997034633A1 (en) * 1996-03-20 1997-09-25 Bristol-Myers Squibb Company Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith

Also Published As

Publication number Publication date
BR9810620A (pt) 2000-10-03
HUP0003160A3 (en) 2002-09-30
US20030072754A1 (en) 2003-04-17
NZ502052A (en) 2001-01-26
CN1195546C (zh) 2005-04-06
HK1033548A1 (en) 2001-09-07
KR20010013965A (ko) 2001-02-26
IS5273A (is) 1999-11-26
CN1651919A (zh) 2005-08-10
NO996275L (no) 2000-02-21
EA200000058A1 (ru) 2000-08-28
EP1051191A2 (en) 2000-11-15
KR100634847B1 (ko) 2006-10-17
CA2294154A1 (en) 1998-12-30
AU730763B2 (en) 2001-03-15
EE9900588A (et) 2000-08-15
HUP0003160A2 (hu) 2001-01-29
CN1261286A (zh) 2000-07-26
EP1051191B1 (en) 2006-09-20
DE69835965T2 (de) 2007-06-14
JP2002506446A (ja) 2002-02-26
EA002550B1 (ru) 2002-06-27
IL133303A0 (en) 2001-04-30
WO1998058669A2 (en) 1998-12-30
BG64976B1 (bg) 2006-11-30
AU7983098A (en) 1999-01-04
NO996275D0 (no) 1999-12-17
WO1998058669A3 (en) 1999-04-29
ATE339966T1 (de) 2006-10-15
TR199903142T2 (xx) 2000-09-21
DE69835965D1 (de) 2006-11-02
US20070292440A1 (en) 2007-12-20
SK180299A3 (en) 2000-06-12

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