BG104009A - Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists - Google Patents

Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists

Info

Publication number
BG104009A
BG104009A BG104009A BG10400999A BG104009A BG 104009 A BG104009 A BG 104009A BG 104009 A BG104009 A BG 104009A BG 10400999 A BG10400999 A BG 10400999A BG 104009 A BG104009 A BG 104009A
Authority
BG
Bulgaria
Prior art keywords
alkyl
optionally substituted
alkylamino
aryl
group
Prior art date
Application number
BG104009A
Other languages
Bulgarian (bg)
English (en)
Inventor
Giuseppe Giardina
Mario Grugni
Davide Graziani
Luca Raveglia
Original Assignee
Smithkline Beecham S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en
Priority claimed from IT002354 external-priority patent/IT1295358B1/it
Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it
Application filed by Smithkline Beecham S.P.A. filed Critical Smithkline Beecham S.P.A.
Publication of BG104009A publication Critical patent/BG104009A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D251/00Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40Nitrogen atoms
    • C07D251/48Two nitrogen atoms
    • C07D251/52Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG104009A 1997-05-23 1999-12-14 Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists BG104009A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710750.2A GB9710750D0 (en) 1997-05-23 1997-05-23 Novel compounds
IT002354 IT1295358B1 (it) 1997-10-17 1997-10-17 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it) 1997-12-16 1997-12-16 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Publications (1)

Publication Number Publication Date
BG104009A true BG104009A (en) 2000-07-31

Family

ID=27268859

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104009A BG104009A (en) 1997-05-23 1999-12-14 Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists

Country Status (26)

Country Link
EP (1) EP0983262B1 (tr)
JP (1) JP2002500645A (tr)
CN (1) CN1264378A (tr)
AP (1) AP9901695A0 (tr)
AR (1) AR012732A1 (tr)
AT (1) ATE244711T1 (tr)
AU (1) AU8209898A (tr)
BG (1) BG104009A (tr)
BR (1) BR9809652A (tr)
CA (1) CA2291111A1 (tr)
CO (1) CO4950515A1 (tr)
DE (1) DE69816290T2 (tr)
DZ (1) DZ2498A1 (tr)
EA (1) EA199901062A1 (tr)
ES (1) ES2201509T3 (tr)
HU (1) HUP0002300A3 (tr)
ID (1) ID22876A (tr)
IL (1) IL133036A0 (tr)
MA (1) MA26501A1 (tr)
NO (1) NO995711L (tr)
OA (1) OA11515A (tr)
PE (1) PE75199A1 (tr)
PL (1) PL336942A1 (tr)
SK (1) SK159299A3 (tr)
TR (1) TR199902883T2 (tr)
WO (1) WO1998052942A1 (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143137A0 (en) * 1998-11-20 2002-04-21 Smithkline Beecham Spa Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
WO2000058303A1 (en) 1999-03-29 2000-10-05 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
WO2000064877A1 (en) 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
WO2002013825A1 (en) * 2000-08-11 2002-02-21 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
AU2002220702A1 (en) * 2000-11-13 2002-05-21 Glaxosmithkline S.P.A. Quinoline derivatives as nk-3 and nk-2 antagonists
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
AU2002226356A1 (en) * 2000-11-28 2002-06-11 Glaxosmithkline S.P.A. Quinoline derivatives as nk-3 antagonists
US6540733B2 (en) 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
WO2002083664A1 (en) * 2001-04-11 2002-10-24 Glaxosmithkline S.P.A. 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
GB0425075D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
MX2007014831A (es) * 2005-06-03 2008-02-15 Astrazeneca Ab Derivados de quinolina como antagonistas de neurocinina-3.
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) * 2007-12-12 2009-04-23 Drebo Werkzeugfabrik Gmbh Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL186075B1 (pl) * 1994-05-27 2003-10-31 Smithkline Beechem Spa N-(-etylobenzylo)-3-hydroksy-2-fenylochinolino-4-karboksyamid oraz kompozycja farmaceutyczna zawierająca ten związek
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Also Published As

Publication number Publication date
ID22876A (id) 1999-12-16
EP0983262B1 (en) 2003-07-09
ES2201509T3 (es) 2004-03-16
EP0983262A1 (en) 2000-03-08
EA199901062A1 (ru) 2000-08-28
OA11515A (en) 2004-02-04
PE75199A1 (es) 1999-10-22
JP2002500645A (ja) 2002-01-08
AP9901695A0 (en) 1999-12-31
DE69816290T2 (de) 2004-05-27
HUP0002300A2 (hu) 2001-06-28
DZ2498A1 (fr) 2003-01-25
CA2291111A1 (en) 1998-11-26
TR199902883T2 (tr) 2000-05-22
SK159299A3 (en) 2000-06-12
CN1264378A (zh) 2000-08-23
IL133036A0 (en) 2001-03-19
NO995711L (no) 2000-01-19
BR9809652A (pt) 2001-09-11
NO995711D0 (no) 1999-11-22
ATE244711T1 (de) 2003-07-15
CO4950515A1 (es) 2000-09-01
AR012732A1 (es) 2000-11-08
AU8209898A (en) 1998-12-11
PL336942A1 (en) 2000-07-17
HUP0002300A3 (en) 2002-01-28
WO1998052942A1 (en) 1998-11-26
DE69816290D1 (de) 2003-08-14
MA26501A1 (fr) 2004-12-20

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