BG104009A - Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists - Google Patents

Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists

Info

Publication number
BG104009A
BG104009A BG104009A BG10400999A BG104009A BG 104009 A BG104009 A BG 104009A BG 104009 A BG104009 A BG 104009A BG 10400999 A BG10400999 A BG 10400999A BG 104009 A BG104009 A BG 104009A
Authority
BG
Bulgaria
Prior art keywords
alkyl
optionally substituted
alkylamino
aryl
group
Prior art date
Application number
BG104009A
Other languages
Bulgarian (bg)
English (en)
Inventor
Giuseppe Giardina
Mario Grugni
Davide Graziani
Luca Raveglia
Original Assignee
Smithkline Beecham S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en
Priority claimed from IT002354 external-priority patent/IT1295358B1/it
Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it
Application filed by Smithkline Beecham S.P.A. filed Critical Smithkline Beecham S.P.A.
Publication of BG104009A publication Critical patent/BG104009A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D251/00Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40Nitrogen atoms
    • C07D251/48Two nitrogen atoms
    • C07D251/52Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG104009A 1997-05-23 1999-12-14 Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists BG104009A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9710750.2A GB9710750D0 (en) 1997-05-23 1997-05-23 Novel compounds
IT002354 IT1295358B1 (it) 1997-10-17 1997-10-17 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it) 1997-12-16 1997-12-16 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
PCT/EP1998/003014 WO1998052942A1 (en) 1997-05-23 1998-05-18 Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists

Publications (1)

Publication Number Publication Date
BG104009A true BG104009A (en) 2000-07-31

Family

ID=27268859

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104009A BG104009A (en) 1997-05-23 1999-12-14 Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists

Country Status (26)

Country Link
EP (1) EP0983262B1 (de)
JP (1) JP2002500645A (de)
CN (1) CN1264378A (de)
AP (1) AP9901695A0 (de)
AR (1) AR012732A1 (de)
AT (1) ATE244711T1 (de)
AU (1) AU8209898A (de)
BG (1) BG104009A (de)
BR (1) BR9809652A (de)
CA (1) CA2291111A1 (de)
CO (1) CO4950515A1 (de)
DE (1) DE69816290T2 (de)
DZ (1) DZ2498A1 (de)
EA (1) EA199901062A1 (de)
ES (1) ES2201509T3 (de)
HU (1) HUP0002300A3 (de)
ID (1) ID22876A (de)
IL (1) IL133036A0 (de)
MA (1) MA26501A1 (de)
NO (1) NO995711L (de)
OA (1) OA11515A (de)
PE (1) PE75199A1 (de)
PL (1) PL336942A1 (de)
SK (1) SK159299A3 (de)
TR (1) TR199902883T2 (de)
WO (1) WO1998052942A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
MXPA01005095A (es) * 1998-11-20 2002-04-24 Smithkline Beecham Spa Derivados de quinolin-4-carboxamida como antagonistas de receptor de neurocinina-3 y neurocinina-2.
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
JP2002540203A (ja) 1999-03-29 2002-11-26 ニューロゲン コーポレイション Nk−3および/またはgaba(a)受容体リガンドとしての4−置換キノリン誘導体
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
AU2001276556A1 (en) * 2000-08-11 2002-02-25 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
EP1334089A1 (de) * 2000-11-13 2003-08-13 GlaxoSmithKline S.p.A. Chinolinderivate als nk-3- und nk-2-antagonisten
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
EP1351953A1 (de) * 2000-11-28 2003-10-15 GlaxoSmithKline S.p.A. Chinolinderivate als nk-3-antagonisten
US6540733B2 (en) 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
EP1659120A1 (de) * 2001-04-11 2006-05-24 GlaxoSmithKline S.p.A. 3-substituierte Chinolin-4-Carboxamidderivate als NK-3 und NK-2 Rezeptor Antagonisten
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
GB0425075D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
KR20080016591A (ko) * 2005-06-03 2008-02-21 아스트라제네카 아베 Nk3 길항제로서의 퀴놀린 유도체
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) * 2007-12-12 2009-04-23 Drebo Werkzeugfabrik Gmbh Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE246677T1 (de) * 1994-05-27 2003-08-15 Smithkline Beecham Farma Chinolinderivate als tachykinin nk3 rezeptor antagonisten
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Also Published As

Publication number Publication date
CA2291111A1 (en) 1998-11-26
CN1264378A (zh) 2000-08-23
HUP0002300A2 (hu) 2001-06-28
EP0983262A1 (de) 2000-03-08
PE75199A1 (es) 1999-10-22
OA11515A (en) 2004-02-04
AR012732A1 (es) 2000-11-08
BR9809652A (pt) 2001-09-11
PL336942A1 (en) 2000-07-17
EA199901062A1 (ru) 2000-08-28
MA26501A1 (fr) 2004-12-20
EP0983262B1 (de) 2003-07-09
NO995711L (no) 2000-01-19
WO1998052942A1 (en) 1998-11-26
AU8209898A (en) 1998-12-11
TR199902883T2 (xx) 2000-05-22
DZ2498A1 (fr) 2003-01-25
ID22876A (id) 1999-12-16
NO995711D0 (no) 1999-11-22
DE69816290T2 (de) 2004-05-27
HUP0002300A3 (en) 2002-01-28
ES2201509T3 (es) 2004-03-16
JP2002500645A (ja) 2002-01-08
DE69816290D1 (de) 2003-08-14
SK159299A3 (en) 2000-06-12
AP9901695A0 (en) 1999-12-31
IL133036A0 (en) 2001-03-19
ATE244711T1 (de) 2003-07-15
CO4950515A1 (es) 2000-09-01

Similar Documents

Publication Publication Date Title
BG104009A (en) Quinoline-4-carboxamide derivatives as neuroquinine-2 and neuroquinine-3 receptor antagonists
MX9804108A (es) Derivados de quinolina-4-carboxamida, su preparacion y uso como antagonistas receptores de neuroquinina 3 (nk-3)- y neuroquinina 2 (kn-2).
AR004972A1 (es) Compuesto quinolino 4-carboxamidas n-sustituidas, un procedimiento para su preparacion, el uso de los mismos para la fabricacion de un medicamento, una composicion farmaceutica y un antagonista nk-2/nk-3 combinado.
NO20004778L (no) Amidderivater og nociceptin antagonister
BR9915475A (pt) Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2
DE69710319D1 (de) Para-substituierte phenylpropansäure derivate als integrin-antagonisten
DK1539700T3 (da) 8-hydroxyquinolin-derivater
UA72917C2 (en) Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor
CA2238171A1 (en) Quinoline derivatives as nk3 antagonists
EE9800062A (et) 8-asabitsüklo[3.2.1.]okt-2-eeni derivaadid, nende valmistamine ja kasutamine
SE0101579D0 (sv) New compounds
EA200400994A1 (ru) Новые 1,2,3-замещенные производные индолизина, являющиеся ингибиторами факторов роста фибробластов, способ их получения и фармацевтические композиции, содержащие их
MY146599A (en) New azetidine compounds
BG100883A (en) Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors
HUP0302193A2 (hu) 1,4-Diazabiciklo[3.2.2]nonán-benzoxazol,-benzotiazol és -benzimidazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
ATE469157T1 (de) Tetrahydrofuroä3,4-düdioxolverbindungen und zusammensetzungen und verfahren zur inhibierung der trombozytenaggregation
DE69934514D1 (de) Chinolinderivate als nk-2 und nk-3 rezeptor-liganden
HUP0004855A2 (hu) Eljárás kinolinszármazékok előállítására és az eljárás intermedierjei
EA200301171A1 (ru) Новые соединения трициклических дигидрохинолинов, способ их получения и фармацевтические композиции, содержащие их
YU34499A (sh) Derivati 5-aroilnaftalena
AR035718A1 (es) Derivados de quinolina, procedimientos para su preparacion, composiciones farmaceuticas que lo comprenden, y el uso de tales compuestos en la fabricacion de medicamentos
NZ323388A (en) Quinoline-4-carboxamide derivatives, their preparation and their use as neurokinin 3 (NK-3) and neurokinin 2 (NK-2) receptor antagonists
BG106079A (en) Cyclocarbamate derivatives as progesterone receptor modulators
BR9609548A (pt) Composto heterocíclicos para o tratamento da dor método para induzir analgesia num mamífero e método para ativar um receptor opióide num mamífero
HUP0000768A2 (hu) Szubsztituált benzo[1,4]dioxánok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények