OA11515A - Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. - Google Patents

Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. Download PDF

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Publication number
OA11515A
OA11515A OA9900253A OA9900253A OA11515A OA 11515 A OA11515 A OA 11515A OA 9900253 A OA9900253 A OA 9900253A OA 9900253 A OA9900253 A OA 9900253A OA 11515 A OA11515 A OA 11515A
Authority
OA
OAPI
Prior art keywords
compound
alkyl
formula
group
aryl
Prior art date
Application number
OA9900253A
Other languages
English (en)
Inventor
Giusoppe Arnaldo Mari Giardina
Mario Grugni
Davide Graziani
Francesco Ravegliaiuca
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9710750.2A external-priority patent/GB9710750D0/en
Priority claimed from IT002354 external-priority patent/IT1295358B1/it
Priority claimed from ITMI972775 external-priority patent/IT1296976B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of OA11515A publication Critical patent/OA11515A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA9900253A 1997-05-23 1999-11-23 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists. OA11515A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9710750.2A GB9710750D0 (en) 1997-05-23 1997-05-23 Novel compounds
IT002354 IT1295358B1 (it) 1997-10-17 1997-10-17 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3
ITMI972775 IT1296976B1 (it) 1997-12-16 1997-12-16 Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3

Publications (1)

Publication Number Publication Date
OA11515A true OA11515A (en) 2004-02-04

Family

ID=27268859

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9900253A OA11515A (en) 1997-05-23 1999-11-23 Quinoline-4-carboxamide derivatives as NK-2 and NK-3 receptor antagonists.

Country Status (26)

Country Link
EP (1) EP0983262B1 (de)
JP (1) JP2002500645A (de)
CN (1) CN1264378A (de)
AP (1) AP9901695A0 (de)
AR (1) AR012732A1 (de)
AT (1) ATE244711T1 (de)
AU (1) AU8209898A (de)
BG (1) BG104009A (de)
BR (1) BR9809652A (de)
CA (1) CA2291111A1 (de)
CO (1) CO4950515A1 (de)
DE (1) DE69816290T2 (de)
DZ (1) DZ2498A1 (de)
EA (1) EA199901062A1 (de)
ES (1) ES2201509T3 (de)
HU (1) HUP0002300A3 (de)
ID (1) ID22876A (de)
IL (1) IL133036A0 (de)
MA (1) MA26501A1 (de)
NO (1) NO995711L (de)
OA (1) OA11515A (de)
PE (1) PE75199A1 (de)
PL (1) PL336942A1 (de)
SK (1) SK159299A3 (de)
TR (1) TR199902883T2 (de)
WO (1) WO1998052942A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9825554D0 (en) 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
MXPA01005095A (es) * 1998-11-20 2002-04-24 Smithkline Beecham Spa Derivados de quinolin-4-carboxamida como antagonistas de receptor de neurocinina-3 y neurocinina-2.
US6780875B2 (en) * 1998-11-20 2004-08-24 Smithkline Beecham S.P.A. Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
JP2002540203A (ja) 1999-03-29 2002-11-26 ニューロゲン コーポレイション Ｎｋ−３および／またはｇａｂａ（ａ）受容体リガンドとしての４−置換キノリン誘導体
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
AU2001276556A1 (en) * 2000-08-11 2002-02-25 Smithkline Beecham P.L.C. Novel pharmaceutical use of quinnoline derivatives
EP1334089A1 (de) * 2000-11-13 2003-08-13 GlaxoSmithKline S.p.A. Chinolinderivate als nk-3- und nk-2-antagonisten
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
EP1351953A1 (de) * 2000-11-28 2003-10-15 GlaxoSmithKline S.p.A. Chinolinderivate als nk-3-antagonisten
US6540733B2 (en) 2000-12-29 2003-04-01 Corazon Technologies, Inc. Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
EP1659120A1 (de) * 2001-04-11 2006-05-24 GlaxoSmithKline S.p.A. 3-substituierte Chinolin-4-Carboxamidderivate als NK-3 und NK-2 Rezeptor Antagonisten
GB0109122D0 (en) * 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
MY134211A (en) * 2001-05-18 2007-11-30 Smithkline Beecham Corp Novel use
GB0425075D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0425076D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
KR20080016591A (ko) * 2005-06-03 2008-02-21 아스트라제네카 아베 Ｎｋ3 길항제로서의 퀴놀린 유도체
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
DE202007017299U1 (de) * 2007-12-12 2009-04-23 Drebo Werkzeugfabrik Gmbh Bohrer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE246677T1 (de) * 1994-05-27 2003-08-15 Smithkline Beecham Farma Chinolinderivate als tachykinin nk3 rezeptor antagonisten
AR004735A1 (es) * 1995-11-24 1999-03-10 Smithkline Beecham Spa Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento.

Also Published As

Publication number Publication date
CA2291111A1 (en) 1998-11-26
CN1264378A (zh) 2000-08-23
HUP0002300A2 (hu) 2001-06-28
EP0983262A1 (de) 2000-03-08
PE75199A1 (es) 1999-10-22
BG104009A (en) 2000-07-31
AR012732A1 (es) 2000-11-08
BR9809652A (pt) 2001-09-11
PL336942A1 (en) 2000-07-17
EA199901062A1 (ru) 2000-08-28
MA26501A1 (fr) 2004-12-20
EP0983262B1 (de) 2003-07-09
NO995711L (no) 2000-01-19
WO1998052942A1 (en) 1998-11-26
AU8209898A (en) 1998-12-11
TR199902883T2 (xx) 2000-05-22
DZ2498A1 (fr) 2003-01-25
ID22876A (id) 1999-12-16
NO995711D0 (no) 1999-11-22
DE69816290T2 (de) 2004-05-27
HUP0002300A3 (en) 2002-01-28
ES2201509T3 (es) 2004-03-16
JP2002500645A (ja) 2002-01-08
DE69816290D1 (de) 2003-08-14
SK159299A3 (en) 2000-06-12
AP9901695A0 (en) 1999-12-31
IL133036A0 (en) 2001-03-19
ATE244711T1 (de) 2003-07-15
CO4950515A1 (es) 2000-09-01

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