BG102623A - New derivatives of benzoylguanadine, methods for their preparation and application for the manufacture of medicamentous forms - Google Patents

New derivatives of benzoylguanadine, methods for their preparation and application for the manufacture of medicamentous forms

Info

Publication number
BG102623A
BG102623A BG102623A BG10262398A BG102623A BG 102623 A BG102623 A BG 102623A BG 102623 A BG102623 A BG 102623A BG 10262398 A BG10262398 A BG 10262398A BG 102623 A BG102623 A BG 102623A
Authority
BG
Bulgaria
Prior art keywords
benzoylguanadine
manufacture
methods
application
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BG102623A
Other languages
Bulgarian (bg)
English (en)
Inventor
Erich Buerger
Christian Eickmeier
Otto Roos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BG102623A publication Critical patent/BG102623A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG102623A 1996-01-16 1998-07-10 New derivatives of benzoylguanadine, methods for their preparation and application for the manufacture of medicamentous forms Pending BG102623A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19601303A DE19601303A1 (de) 1996-01-16 1996-01-16 Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
PCT/EP1997/000177 WO1997026253A1 (de) 1996-01-16 1997-01-16 Neuartige benzoylguanidin-derivate, verfahren zu ihrer herstellung und ihre verwendung bei der herstellung von arzneimitteln

Publications (1)

Publication Number Publication Date
BG102623A true BG102623A (en) 1999-03-31

Family

ID=7782846

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102623A Pending BG102623A (en) 1996-01-16 1998-07-10 New derivatives of benzoylguanadine, methods for their preparation and application for the manufacture of medicamentous forms

Country Status (27)

Country Link
US (1) US6114335A (de)
EP (1) EP0882031A1 (de)
JP (1) JP2000503309A (de)
KR (1) KR19990077304A (de)
CN (1) CN1072663C (de)
AR (1) AR005468A1 (de)
AU (1) AU722619B2 (de)
BG (1) BG102623A (de)
BR (1) BR9707002A (de)
CA (1) CA2240075A1 (de)
CO (1) CO4761058A1 (de)
CZ (1) CZ225398A3 (de)
DE (1) DE19601303A1 (de)
EE (1) EE9800200A (de)
HK (1) HK1016981A1 (de)
HU (1) HUP9900584A3 (de)
IL (1) IL124779A0 (de)
NO (1) NO311517B1 (de)
NZ (1) NZ326347A (de)
PL (1) PL327854A1 (de)
RU (1) RU2181720C2 (de)
SK (1) SK282751B6 (de)
TR (1) TR199801328T2 (de)
TW (1) TW426673B (de)
UA (1) UA48214C2 (de)
WO (1) WO1997026253A1 (de)
ZA (1) ZA97277B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19843489B4 (de) * 1998-09-22 2006-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Benzoylguanidin-Abkömmlinge mit vorteilhaften Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln, sowie diese enthaltende pharmazeutische Zubereitung
US6323207B1 (en) * 1998-09-22 2001-11-27 Boehringer Ingelheim Pharma Kg Benzoylguanidine derivatives
JP2000219674A (ja) * 1999-01-29 2000-08-08 Daiichi Radioisotope Labs Ltd 新規アラルキルグアニジン化合物
AU2002253795B2 (en) * 2000-11-30 2007-02-01 The Children's Medical Center Corporation Synthesis of 4-Amino-Thalidomide enantiomers
IL147696A0 (en) * 2001-01-25 2002-08-14 Pfizer Prod Inc Combination therapy
DE10106970A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Neues Benzoylguanidinsalz
US6730678B2 (en) * 2001-02-15 2004-05-04 Boehringer Ingelheim Pharma Kg Benzoylguanidine salt and hydrates thereof
DE10204989A1 (de) * 2002-02-07 2003-08-21 Aventis Pharma Gmbh Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
UA83504C2 (en) 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
EP1797068B1 (de) * 2004-09-03 2013-10-09 Celgene Corporation Verfahren zur herstellung substituierter 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline
AU2006265019B2 (en) * 2005-06-30 2011-10-13 Celgene Corporation Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
WO2007062222A2 (en) * 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
WO2007136640A2 (en) * 2006-05-16 2007-11-29 Celgene Corporation Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
WO2010005783A1 (en) * 2008-07-08 2010-01-14 Boehringer Ingelheim International Gmbh Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors
WO2010025448A2 (en) * 2008-08-29 2010-03-04 University Of South Florida Inhibition of cell proliferation
EP2817300B1 (de) 2012-02-21 2018-04-25 Celgene Corporation Feste formen von 3-(4-nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dion
EP2815749A1 (de) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Feste Form von 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindolin-1,3-dion mit spezifischem Röntgenbeugungsspektrum

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147375T1 (de) * 1992-09-22 1997-01-15 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika
EP0600371B1 (de) * 1992-12-02 1999-02-03 Hoechst Aktiengesellschaft Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
TW250477B (de) * 1992-12-15 1995-07-01 Hoechst Ag
DE4337611A1 (de) * 1993-11-04 1995-05-11 Boehringer Ingelheim Kg Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE4404183A1 (de) * 1994-02-10 1995-08-17 Merck Patent Gmbh 4-Amino-1-piperidylbenzoylguanidine
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine

Also Published As

Publication number Publication date
AU722619B2 (en) 2000-08-10
DE19601303A1 (de) 1997-07-17
JP2000503309A (ja) 2000-03-21
HUP9900584A2 (hu) 1999-07-28
EE9800200A (et) 1998-12-15
US6114335A (en) 2000-09-05
HK1016981A1 (en) 1999-11-12
HUP9900584A3 (en) 2001-01-29
NO983261L (no) 1998-07-15
ZA97277B (en) 1997-07-16
UA48214C2 (uk) 2002-08-15
IL124779A0 (en) 1999-01-26
CA2240075A1 (en) 1997-07-24
BR9707002A (pt) 1999-07-20
CN1072663C (zh) 2001-10-10
NO311517B1 (no) 2001-12-03
CN1208409A (zh) 1999-02-17
KR19990077304A (ko) 1999-10-25
TR199801328T2 (xx) 1998-10-21
RU2181720C2 (ru) 2002-04-27
EP0882031A1 (de) 1998-12-09
CZ225398A3 (cs) 1998-12-16
SK282751B6 (sk) 2002-12-03
WO1997026253A1 (de) 1997-07-24
NZ326347A (en) 2001-03-30
NO983261D0 (no) 1998-07-15
CO4761058A1 (es) 1999-04-27
SK95798A3 (en) 1999-01-11
TW426673B (en) 2001-03-21
PL327854A1 (en) 1999-01-04
AU1442997A (en) 1997-08-11
AR005468A1 (es) 1999-06-23

Similar Documents

Publication Publication Date Title
BG102623A (en) New derivatives of benzoylguanadine, methods for their preparation and application for the manufacture of medicamentous forms
BG101132A (en) Pyridoanilated thienyl and furanyl oxazolidinons
BG103251A (en) Oxydiazols, methods for their preparation and application as medicamentous forms
MXPA02004666A (es) Gelatinas recombinantes.
PL380081A1 (pl) Pochodne 3,3-difenylopropyloamin, sposoby ich wytwarzania, kompozycja farmaceutyczna oraz zastosowania
BG107590A (en) Synthetioc erythropoiesis stimulating proteins
PL336580A1 (en) Fine-molecular compounds useful in treating inflammatory diseases
BG101139A (en) Heteroatoms-containing cyclopentanopyridyloxazolidinons
MY131298A (en) 5-heteroyl indole derivatives
PL323726A1 (en) Novel derivatives of dolastatin, their production and application
EP0758247A4 (de) O-desulfatierte heparin-derivate, verfahren zu deren herstellung und verwendungen
BG103914A (en) Maintained separation of delayed gels
BG103219A (en) Benzamidine derivatives and their application as medicamentous forms with ltb-4-antagonist effect
IS4945A (is) Tilbúnar fjölsykrur, aðferð við að framleiða þær og lyfjablöndur sem innihalda þær
BG102362A (en) New derivatives of amino acids, their preparation and application
AU5186799A (en) Peptides of il-2 and derivatives thereof and their use as therapeutic agents
EP0911393A4 (de) Verfahren zur herstellung und verwendung eines neuen peptides
HUP9901616A3 (en) Novel benzofuranone derivatives, process for their production and pharmaceutical compositions of the same
HRP20000480B1 (en) Synthetic polysaccharides, their method of production and pharmaceutical compositions containing the same
BG102395A (en) New phenylamidine derivatives, method for their preparation and application as medicamentous forms
BG102814A (en) New derivatives of carboxylic acid, their preparation and application
BG104291A (en) 3-substituted tetrahydropyridopyrimidinone derivatives, method for producing the same, and their use
MY107449A (en) Bcrf1 proteins as inhibitors of interferon- gamma.
BG102770A (en) New derivatives of carboxylic acids, their preparation and application
BG100248A (en) Squalene synthetase inhibitors