BG102346A - Твърди лекарствени форми, получени чрез екструзияна стопилка, включваща изомалт, активно вещество и полимер - Google Patents
Твърди лекарствени форми, получени чрез екструзияна стопилка, включваща изомалт, активно вещество и полимер Download PDFInfo
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- BG102346A BG102346A BG102346A BG10234698A BG102346A BG 102346 A BG102346 A BG 102346A BG 102346 A BG102346 A BG 102346A BG 10234698 A BG10234698 A BG 10234698A BG 102346 A BG102346 A BG 102346A
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- dose
- isomalt
- dosage forms
- active substance
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- 239000013543 active substance Substances 0.000 title claims abstract description 38
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- 239000000905 isomalt Substances 0.000 title claims abstract description 21
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- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 238000001125 extrusion Methods 0.000 title claims description 20
- 229920000642 polymer Polymers 0.000 title claims description 16
- 239000007787 solid Substances 0.000 title abstract description 3
- 241001062472 Stokellia anisodon Species 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 238000009472 formulation Methods 0.000 claims abstract description 8
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 4
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- 235000010445 lecithin Nutrition 0.000 claims description 12
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 11
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- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
- 229960000881 verapamil hydrochloride Drugs 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046001 vitamin b complex Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19536394A DE19536394A1 (de) | 1995-09-29 | 1995-09-29 | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
| PCT/EP1996/004262 WO1997012603A1 (de) | 1995-09-29 | 1996-09-30 | Feste arzneiformen, erhältlich durch extrusion einer isomalt enthaltenden polymer-wirkstoff-schmelze |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG102346A true BG102346A (bg) | 1998-10-30 |
Family
ID=7773633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102346A BG102346A (bg) | 1995-09-29 | 1998-03-24 | Твърди лекарствени форми, получени чрез екструзияна стопилка, включваща изомалт, активно вещество и полимер |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6187342B1 (es) |
| EP (1) | EP0854707B1 (es) |
| JP (1) | JP4041163B2 (es) |
| KR (1) | KR19990063853A (es) |
| CN (1) | CN1200694C (es) |
| AT (1) | ATE228355T1 (es) |
| AU (1) | AU7282896A (es) |
| BG (1) | BG102346A (es) |
| BR (1) | BR9610799A (es) |
| CA (1) | CA2230950C (es) |
| CZ (1) | CZ95998A3 (es) |
| DE (2) | DE19536394A1 (es) |
| DK (1) | DK0854707T3 (es) |
| ES (1) | ES2187678T3 (es) |
| HU (1) | HUP9903384A3 (es) |
| IL (1) | IL123250A (es) |
| MX (1) | MX9801988A (es) |
| NO (1) | NO981394D0 (es) |
| RU (1) | RU2197228C2 (es) |
| TW (1) | TW438599B (es) |
| WO (1) | WO1997012603A1 (es) |
| ZA (1) | ZA968130B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19809242A1 (de) * | 1998-03-05 | 1999-09-09 | Basf Ag | Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix |
| US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
| WO2001034119A2 (en) * | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| US20070141107A1 (en) * | 2000-03-15 | 2007-06-21 | Orbusneich Medical, Inc. | Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device |
| US8088060B2 (en) * | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
| KR20040100835A (ko) * | 2001-02-15 | 2004-12-02 | 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 | 안정된 제약및 갑상선 내분비 호르몬 구성물 및 그제조방법 |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
| PL364621A1 (en) * | 2001-03-26 | 2004-12-13 | Smithkline Beecham Corporation | Nicotine-containing oral dosage form |
| FR2823974B1 (fr) * | 2001-04-25 | 2004-10-15 | Pf Medicament | Pastille medicamenteuse a liberation lente du principe actif |
| US20030198667A1 (en) * | 2001-08-10 | 2003-10-23 | Franz Andrew G. | Methods of producing dispersible pharmaceutical compositions |
| US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
| US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
| US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
| US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
| US20030195253A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration |
| US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
| US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
| US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
| US20030175337A1 (en) * | 2001-10-29 | 2003-09-18 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
| KR100514590B1 (ko) * | 2001-12-18 | 2005-09-14 | 주식회사 대웅 | 프라바스타틴나트륨 및 안정화제로서의 코폴리비돈을함유하는 약제 조성물 |
| US20040101543A1 (en) * | 2002-03-22 | 2004-05-27 | John Liu | Nicotine-containing oral dosage form |
| US20080051411A1 (en) * | 2002-12-17 | 2008-02-28 | Cink Russell D | Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof |
| DE60313359T2 (de) * | 2002-12-17 | 2008-01-03 | Abbott Gmbh & Co. Kg | Fenofibratsäure enthaltende pharmazeutische zusammensetzung und deren physiologisch verträgliche salze und derivate |
| WO2004069138A2 (en) * | 2003-02-03 | 2004-08-19 | Novartis Ag | Pharmaceutical formulation |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| GB2418854B (en) * | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
| EP2140861A1 (en) * | 2008-06-30 | 2010-01-06 | Abbott GmbH & Co. KG | Pharmaceutical dosage form comprising polymeric carrier composition |
| BR112013008737A2 (pt) * | 2010-10-14 | 2015-09-01 | Abbott Gmbh & Co Kg | Formulação de dispersão sólida de curcuminóide |
| JP5954676B2 (ja) | 2011-03-21 | 2016-07-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アンブロキソールを含む固体製剤 |
| US9375033B2 (en) | 2014-02-14 | 2016-06-28 | R.J. Reynolds Tobacco Company | Tobacco-containing gel composition |
| WO2017175792A1 (ja) * | 2016-04-06 | 2017-10-12 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3612211A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Kontinuierliches verfahren zum tablettieren |
| DE3826946C1 (es) | 1988-08-09 | 1990-03-15 | A. Nattermann & Cie Gmbh, 5000 Koeln, De | |
| ATE221772T1 (de) | 1994-06-14 | 2002-08-15 | Biovail Tech Ltd | Verfahren und apparat zur herstellung von schnelllöslichen dosierungseinheiten und daraus erhältliches produkt |
-
1995
- 1995-09-29 DE DE19536394A patent/DE19536394A1/de not_active Withdrawn
-
1996
- 1996-09-26 TW TW085111773A patent/TW438599B/zh not_active IP Right Cessation
- 1996-09-27 ZA ZA9608130A patent/ZA968130B/xx unknown
- 1996-09-30 EP EP96934494A patent/EP0854707B1/de not_active Expired - Lifetime
- 1996-09-30 IL IL12325096A patent/IL123250A/xx not_active IP Right Cessation
- 1996-09-30 RU RU98108536/14A patent/RU2197228C2/ru active
- 1996-09-30 AU AU72828/96A patent/AU7282896A/en not_active Abandoned
- 1996-09-30 ES ES96934494T patent/ES2187678T3/es not_active Expired - Lifetime
- 1996-09-30 WO PCT/EP1996/004262 patent/WO1997012603A1/de not_active Application Discontinuation
- 1996-09-30 HU HU9903384A patent/HUP9903384A3/hu unknown
- 1996-09-30 CZ CZ98959A patent/CZ95998A3/cs unknown
- 1996-09-30 DK DK96934494T patent/DK0854707T3/da active
- 1996-09-30 DE DE59609923T patent/DE59609923D1/de not_active Expired - Lifetime
- 1996-09-30 US US09/029,362 patent/US6187342B1/en not_active Expired - Lifetime
- 1996-09-30 BR BR9610799A patent/BR9610799A/pt active Search and Examination
- 1996-09-30 KR KR1019980702324A patent/KR19990063853A/ko not_active Application Discontinuation
- 1996-09-30 CA CA002230950A patent/CA2230950C/en not_active Expired - Lifetime
- 1996-09-30 JP JP51396597A patent/JP4041163B2/ja not_active Expired - Lifetime
- 1996-09-30 AT AT96934494T patent/ATE228355T1/de active
- 1996-09-30 CN CNB961972637A patent/CN1200694C/zh not_active Expired - Lifetime
-
1998
- 1998-03-13 MX MX9801988A patent/MX9801988A/es not_active IP Right Cessation
- 1998-03-24 BG BG102346A patent/BG102346A/bg unknown
- 1998-03-27 NO NO981394A patent/NO981394D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11512729A (ja) | 1999-11-02 |
| DK0854707T3 (da) | 2002-12-16 |
| EP0854707B1 (de) | 2002-11-27 |
| NO981394L (no) | 1998-03-27 |
| EP0854707A1 (de) | 1998-07-29 |
| IL123250A0 (en) | 1998-09-24 |
| RU2197228C2 (ru) | 2003-01-27 |
| TW438599B (en) | 2001-06-07 |
| IL123250A (en) | 2000-08-31 |
| ATE228355T1 (de) | 2002-12-15 |
| CN1198094A (zh) | 1998-11-04 |
| DE19536394A1 (de) | 1997-04-03 |
| CN1200694C (zh) | 2005-05-11 |
| CA2230950A1 (en) | 1997-04-10 |
| ES2187678T3 (es) | 2003-06-16 |
| AU7282896A (en) | 1997-04-28 |
| JP4041163B2 (ja) | 2008-01-30 |
| KR19990063853A (ko) | 1999-07-26 |
| BR9610799A (pt) | 1999-07-13 |
| HUP9903384A3 (en) | 2001-04-28 |
| CA2230950C (en) | 2007-12-04 |
| MX9801988A (es) | 1998-08-30 |
| US6187342B1 (en) | 2001-02-13 |
| CZ95998A3 (cs) | 1998-08-12 |
| ZA968130B (en) | 1998-03-27 |
| NO981394D0 (no) | 1998-03-27 |
| WO1997012603A1 (de) | 1997-04-10 |
| DE59609923D1 (de) | 2003-01-09 |
| HUP9903384A2 (hu) | 2000-10-28 |
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