BG101847A - Варианти на човешка дезоксирибонуклеаза i - Google Patents

Варианти на човешка дезоксирибонуклеаза i

Info

Publication number
BG101847A
BG101847A BG101847A BG10184797A BG101847A BG 101847 A BG101847 A BG 101847A BG 101847 A BG101847 A BG 101847A BG 10184797 A BG10184797 A BG 10184797A BG 101847 A BG101847 A BG 101847A
Authority
BG
Bulgaria
Prior art keywords
human dnase
variants
actin
relates
resistant variants
Prior art date
Application number
BG101847A
Other languages
English (en)
Other versions
BG64423B1 (bg
Inventor
Robert LAZARUS
Steven Shak
Jana Ulmer
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/en
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BG101847A publication Critical patent/BG101847A/bg
Publication of BG64423B1 publication Critical patent/BG64423B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Аминокиселинните последователности на варианти начовешка дезоксирибонуклеаза I редуцират афинитетаза свързване на актин. Осигурени са последователности на нуклеинови киселини, кодиращи такива актинрезистентни варианти, при което става възможно получаването им в количества, достатъчни да бъдат използвани в клиничната практика. Изобретението се отнася също до фармацевтични състави и до терапевтичните приложения в клиниката на актинрезистентните варианти на човешка дезоксирибонуклеаза I.
BG101847A 1995-02-24 1997-08-21 Варианти на човешка дезоксирибонуклеаза i BG64423B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
US54052795A 1995-10-10 1995-10-10

Publications (2)

Publication Number Publication Date
BG101847A true BG101847A (bg) 1998-07-31
BG64423B1 BG64423B1 (bg) 2005-01-31

Family

ID=24155835

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101847A BG64423B1 (bg) 1995-02-24 1997-08-21 Варианти на човешка дезоксирибонуклеаза i

Country Status (5)

Country Link
JP (3) JP4624380B2 (bg)
BG (1) BG64423B1 (bg)
CZ (1) CZ297463B6 (bg)
MX (1) MX9706429A (bg)
PT (1) PT854927E (bg)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007572A1 (en) * 1988-12-23 1990-07-12 Genentech, Inc. HUMAN DNase
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I

Also Published As

Publication number Publication date
JP4624380B2 (ja) 2011-02-02
BG64423B1 (bg) 2005-01-31
CZ297463B6 (cs) 2006-12-13
JP2007312781A (ja) 2007-12-06
MX9706429A (es) 1997-11-29
JP2010057516A (ja) 2010-03-18
JP2010088452A (ja) 2010-04-22
PT854927E (pt) 2008-09-08
CZ267897A3 (cs) 1998-01-14

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