CZ267897A3 - Na aktin rezistentní varianta lidské DNázy I mající hydrolytickou aktivitu štěpení DNA a izolovaná nukleová kyselina ji kodující a způsob léčby pacienta majícího plicní nemoc nebo chorobu obsahující podávání terapeuticky účinného množství na aktin rezistentní varianty lidské DNázy I a farmaceutický prostředek obsahující na aktin rezistentní variantu lidské DNázy I mající hydrolytickou aktivitu štěpení DNA - Google Patents

Na aktin rezistentní varianta lidské DNázy I mající hydrolytickou aktivitu štěpení DNA a izolovaná nukleová kyselina ji kodující a způsob léčby pacienta majícího plicní nemoc nebo chorobu obsahující podávání terapeuticky účinného množství na aktin rezistentní varianty lidské DNázy I a farmaceutický prostředek obsahující na aktin rezistentní variantu lidské DNázy I mající hydrolytickou aktivitu štěpení DNA

Info

Publication number
CZ267897A3
CZ267897A3 CZ972678A CZ267897A CZ267897A3 CZ 267897 A3 CZ267897 A3 CZ 267897A3 CZ 972678 A CZ972678 A CZ 972678A CZ 267897 A CZ267897 A CZ 267897A CZ 267897 A3 CZ267897 A3 CZ 267897A3
Authority
CZ
Czechia
Prior art keywords
ase
actin
human
resistant
exhibiting
Prior art date
Application number
CZ972678A
Other languages
English (en)
Other versions
CZ297463B6 (cs
Inventor
Robert A. Lazarus
Steven Shak
Jana S. Ulmer
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/en
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CZ267897A3 publication Critical patent/CZ267897A3/cs
Publication of CZ297463B6 publication Critical patent/CZ297463B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CZ0267897A 1995-02-24 1996-02-21 Varianta lidské DNázy I, mající DNA hydrolytickouaktivitu a aminokyselinovou sekvenci mající nejméne 90 % identity s aminokyselinovou sekvencí prírodní lidské DNázy I CZ297463B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
US54052795A 1995-10-10 1995-10-10

Publications (2)

Publication Number Publication Date
CZ267897A3 true CZ267897A3 (cs) 1998-01-14
CZ297463B6 CZ297463B6 (cs) 2006-12-13

Family

ID=24155835

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ0267897A CZ297463B6 (cs) 1995-02-24 1996-02-21 Varianta lidské DNázy I, mající DNA hydrolytickouaktivitu a aminokyselinovou sekvenci mající nejméne 90 % identity s aminokyselinovou sekvencí prírodní lidské DNázy I

Country Status (5)

Country Link
JP (3) JP4624380B2 (cs)
BG (1) BG64423B1 (cs)
CZ (1) CZ297463B6 (cs)
MX (1) MX9706429A (cs)
PT (1) PT854927E (cs)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130120T3 (es) * 1988-12-23 1999-07-01 Genentech Inc Procedimiento para la preparacion de la adnasa humana.
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I

Also Published As

Publication number Publication date
BG64423B1 (bg) 2005-01-31
MX9706429A (es) 1997-11-29
PT854927E (pt) 2008-09-08
JP2010057516A (ja) 2010-03-18
JP2010088452A (ja) 2010-04-22
BG101847A (en) 1998-07-31
JP4624380B2 (ja) 2011-02-02
CZ297463B6 (cs) 2006-12-13
JP2007312781A (ja) 2007-12-06

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CZ267897A3 (cs) Na aktin rezistentní varianta lidské DNázy I mající hydrolytickou aktivitu štěpení DNA a izolovaná nukleová kyselina ji kodující a způsob léčby pacienta majícího plicní nemoc nebo chorobu obsahující podávání terapeuticky účinného množství na aktin rezistentní varianty lidské DNázy I a farmaceutický prostředek obsahující na aktin rezistentní variantu lidské DNázy I mající hydrolytickou aktivitu štěpení DNA
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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20160221