BG101202A - Нови производни на 3-бром- и 3,3-дибром-4-оксо-1- азетидини, метод за тяхното получаване и използването им - Google Patents

Нови производни на 3-бром- и 3,3-дибром-4-оксо-1- азетидини, метод за тяхното получаване и използването им

Info

Publication number
BG101202A
BG101202A BG101202A BG10120297A BG101202A BG 101202 A BG101202 A BG 101202A BG 101202 A BG101202 A BG 101202A BG 10120297 A BG10120297 A BG 10120297A BG 101202 A BG101202 A BG 101202A
Authority
BG
Bulgaria
Prior art keywords
oxo
dibrom
azetidines
brom
derivatives
Prior art date
Application number
BG101202A
Other languages
English (en)
Other versions
BG62565B1 (bg
Inventor
Irena Lukic
Original Assignee
Pliva Farmaceutska,Kemijska,Prehrambena Ikozmeticka Industrija, Dionicko Drustvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HRP960061 external-priority patent/HRP960061A2/hr
Priority claimed from HRP970036 external-priority patent/HRP970036A2/hr
Application filed by Pliva Farmaceutska,Kemijska,Prehrambena Ikozmeticka Industrija, Dionicko Drustvo filed Critical Pliva Farmaceutska,Kemijska,Prehrambena Ikozmeticka Industrija, Dionicko Drustvo
Publication of BG101202A publication Critical patent/BG101202A/bg
Publication of BG62565B1 publication Critical patent/BG62565B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Производните на 3-бром- и 3,3-дибром-4-оксо-1-азетидини се получават чрез взаимодействие на производни на 2-сулфинова киселина, за предпочитане 2-заместени сулфинамиди на 4-оксо-азетидини с различни халогениращи агенти. След обработване на реакционната смес 2-халогеновите производни на 3-бром- и 3,3-дибром-4-оксо-азетидините се изолират и се подлагат на взаимодействие със сребърен тетрафлуороборат и алкохоли, за да се получат съответните 2-алкоксипроизводни на 3-бром- и 3,3-дибром-4-оксо-азетидини, или 2-халогенови производни на 3-бром- и 3,3-дибром-4-оксо-азетидини се подлагат на взаимодействие със сребърен нитрат в 2-пропанол, за да се получат след обработването на реакционната смес 2-нитроксипроизводни на 3-бром и 3,3-дибром-4-оксо-1-азетидини. Някои новополучени съединения са незащитени и се получават производни със свободна карбоксилна група. Получените съединения са компоненти от фармацевтични състави, ефективни при антибактериална и антитуморна терапия.
BG101202A 1996-02-06 1997-02-05 Нови производни на 3-бром- и 3,3-дибром-4-оксо-1-азетидини,метод за тяхното получаване и използването им BG62565B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HRP960061 HRP960061A2 (en) 1996-02-06 1996-02-06 Novel 3-bromo- and 3,3-dibromo-4-okso-1-azetidine derivatives, process for the preparation and use thereof
HRP970036 HRP970036A2 (en) 1997-01-20 1997-01-20 Novel derivatives of 3-bromo and 3,3-dibromo-4-oxo-1-azetidines, process for the preparation thereof and their use

Publications (2)

Publication Number Publication Date
BG101202A true BG101202A (bg) 1998-03-31
BG62565B1 BG62565B1 (bg) 2000-02-29

Family

ID=26317101

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101202A BG62565B1 (bg) 1996-02-06 1997-02-05 Нови производни на 3-бром- и 3,3-дибром-4-оксо-1-азетидини,метод за тяхното получаване и използването им

Country Status (11)

Country Link
US (1) US5843939A (bg)
EP (1) EP0791580A3 (bg)
JP (1) JPH09227511A (bg)
CN (1) CN1164531A (bg)
BG (1) BG62565B1 (bg)
CA (1) CA2196909A1 (bg)
CZ (1) CZ34697A3 (bg)
HU (1) HUP9700366A3 (bg)
PL (1) PL318346A1 (bg)
SI (1) SI9700028A (bg)
SK (1) SK13897A3 (bg)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103524393B (zh) * 2013-10-29 2015-01-07 广东省中医院 氮杂环丁烷-3-磺胺类衍生物及其合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1914386A1 (de) * 1969-03-21 1970-10-08 Hoechst Ag Verfahren zur Herstellung von Carbonsaeureamiden und Sulfonamiden
GB1510794A (en) 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor
US4138408A (en) * 1975-12-20 1979-02-06 Hoechst Aktiengesellschaft ω-Alkoxy derivatives of lactams and process for their manufacture
CA1085392A (en) 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
JPS607635B2 (ja) 1976-04-27 1985-02-26 塩野義製薬株式会社 オキサゾリジン化合物
US4234579A (en) 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IT1102408B (it) 1977-12-23 1985-10-07 Fujisawa Pharmaceutical Co Composti analoghi della cefalosforina e procedimenti per la loro preparazione
WO1982001705A1 (en) * 1980-11-13 1982-05-27 Takeda Chemical Industries Ltd 4-substituted-2-oxoazetidine derivatives and process for their preparation
US4368156A (en) 1981-03-09 1983-01-11 Eli Lilly And Company Preparation of 4-haloazetidin-2-ones from 4-sulfinoazetidin-2-ones
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4515719A (en) 1983-07-22 1985-05-07 Eli Lilly And Company Azetidinone sulfinic acids from cephalosporin sulfones
HRP931047B1 (en) 1993-07-09 2000-02-29 Pliva Pharm & Chem Works 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and their use
WO1995018082A1 (fr) * 1993-12-28 1995-07-06 Otsuka Kagaku Kabushiki Kaisha Agent reducteur d'ozonide

Also Published As

Publication number Publication date
EP0791580A3 (en) 1997-09-03
HUP9700366A3 (en) 1998-11-30
SK13897A3 (en) 1998-05-06
CN1164531A (zh) 1997-11-12
PL318346A1 (en) 1997-08-18
US5843939A (en) 1998-12-01
JPH09227511A (ja) 1997-09-02
SI9700028A (en) 1997-08-31
HU9700366D0 (en) 1997-03-28
BG62565B1 (bg) 2000-02-29
EP0791580A2 (en) 1997-08-27
CZ34697A3 (en) 1997-08-13
CA2196909A1 (en) 1997-08-07
HUP9700366A2 (en) 1997-10-28

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