BE905601A - DICHLOROANILINE DERIVATIVES. - Google Patents

DICHLOROANILINE DERIVATIVES.

Info

Publication number
BE905601A
BE905601A BE0/217292A BE217292A BE905601A BE 905601 A BE905601 A BE 905601A BE 0/217292 A BE0/217292 A BE 0/217292A BE 217292 A BE217292 A BE 217292A BE 905601 A BE905601 A BE 905601A
Authority
BE
Belgium
Prior art keywords
dichloroaniline derivatives
dichloroaniline
derivatives
solvates
asthma
Prior art date
Application number
BE0/217292A
Other languages
French (fr)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE905601A publication Critical patent/BE905601A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/46—Aniline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composés de la formule générale, dans laquelle R1, R2, X, Y et Ar possèdent les significations définies, ainsi que leurs sels et solvates (notamment hydrates) physiologiquement acceptables, qui possèdent une action stimulante au niveau des récepteurs beta 2-adrénergiques et peuvent etre utilisés dans la traitement de maladie associées à l'obstruction réversible des voies respiratoires comme l'asthme et la bronchite chronique.Compounds of the general formula, in which R1, R2, X, Y and Ar have the defined meanings, as well as their physiologically acceptable salts and solvates (in particular hydrates), which have a stimulating action at the level of beta 2-adrenergic receptors and can be used in the treatment of diseases associated with reversible airway obstruction such as asthma and chronic bronchitis.

BE0/217292A 1985-10-15 1986-10-15 DICHLOROANILINE DERIVATIVES. BE905601A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858525321A GB8525321D0 (en) 1985-10-15 1985-10-15 Chemical compounds

Publications (1)

Publication Number Publication Date
BE905601A true BE905601A (en) 1987-04-15

Family

ID=10586651

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217292A BE905601A (en) 1985-10-15 1986-10-15 DICHLOROANILINE DERIVATIVES.

Country Status (21)

Country Link
JP (1) JPS62149651A (en)
KR (1) KR870003970A (en)
AT (1) AT395972B (en)
AU (1) AU591188B2 (en)
BE (1) BE905601A (en)
CA (1) CA1296335C (en)
CH (1) CH669787A5 (en)
DE (1) DE3634974A1 (en)
DK (1) DK491786A (en)
ES (1) ES2002036A6 (en)
FI (1) FI89164C (en)
FR (1) FR2591590B1 (en)
GB (2) GB8525321D0 (en)
IE (1) IE59466B1 (en)
IL (2) IL78432A (en)
IT (1) IT1205360B (en)
NL (1) NL8602575A (en)
NO (1) NO164895C (en)
PT (1) PT83531B (en)
SE (1) SE467541B (en)
ZA (1) ZA867772B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3571808D1 (en) * 1984-04-17 1989-08-31 Glaxo Group Ltd Ethanolamine compounds
GB8718938D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
GB8718939D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
US5149698A (en) * 1987-08-11 1992-09-22 Glaxo Group Limited Chloroaniline derivatives
PT88988B (en) * 1987-11-13 1993-02-26 Glaxo Group Ltd METHOD FOR THE PREPARATION OF PHENETHANOLAMINE DERIVATIVES
EP0322164B1 (en) * 1987-12-18 1993-09-22 Glaxo Group Limited Ethanolamine derivatives
ZA889405B (en) * 1987-12-18 1989-12-27 Glaxo Group Ltd Ethanolamine derivatives
GB8808892D0 (en) * 1988-04-15 1988-05-18 British Bio Technology Gene synthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618005A1 (en) * 1966-09-22 1971-09-09 Thomae Gmbh Dr K Process for the preparation of new amino-dihalogen-phenyl-ethylamines
DE2351281C3 (en) * 1973-10-12 1981-07-30 Dr. Karl Thomae Gmbh, 7950 Biberach Aminophenylethanolamine derivatives, their production and use
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
DE3571808D1 (en) * 1984-04-17 1989-08-31 Glaxo Group Ltd Ethanolamine compounds
GB8426191D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds

Also Published As

Publication number Publication date
IL78432A (en) 1990-09-17
NO164895C (en) 1990-11-28
AT395972B (en) 1993-04-26
FI864137A (en) 1987-04-16
IE862707L (en) 1987-04-15
GB2182658B (en) 1990-01-31
NO864101L (en) 1987-04-21
IT8648547A0 (en) 1986-10-14
GB8525321D0 (en) 1985-11-20
DK491786D0 (en) 1986-10-14
FR2591590A1 (en) 1987-06-19
AU6395986A (en) 1987-04-16
FR2591590B1 (en) 1990-05-11
ZA867772B (en) 1988-07-27
CA1296335C (en) 1992-02-25
AU591188B2 (en) 1989-11-30
NL8602575A (en) 1987-05-04
SE467541B (en) 1992-08-03
SE8604349D0 (en) 1986-10-14
FI864137A0 (en) 1986-10-14
IT1205360B (en) 1989-03-15
GB8624630D0 (en) 1986-11-19
DK491786A (en) 1987-04-16
ES2002036A6 (en) 1988-07-01
IL80294A (en) 1990-11-29
CH669787A5 (en) 1989-04-14
KR870003970A (en) 1987-05-06
PT83531B (en) 1989-05-31
DE3634974A1 (en) 1987-05-27
IE59466B1 (en) 1994-02-23
FI89164C (en) 1993-08-25
FI89164B (en) 1993-05-14
GB2182658A (en) 1987-05-20
JPS62149651A (en) 1987-07-03
SE8604349L (en) 1987-04-16
ATA273486A (en) 1992-09-15
NO864101D0 (en) 1986-10-14
PT83531A (en) 1986-11-01
NO164895B (en) 1990-08-20

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19941031