ES2002036A6 - Dichloroaniline derivatives - Google Patents

Dichloroaniline derivatives

Info

Publication number
ES2002036A6
ES2002036A6 ES8602594A ES8602594A ES2002036A6 ES 2002036 A6 ES2002036 A6 ES 2002036A6 ES 8602594 A ES8602594 A ES 8602594A ES 8602594 A ES8602594 A ES 8602594A ES 2002036 A6 ES2002036 A6 ES 2002036A6
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
alkoxy
hydroxy
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602594A
Other languages
Spanish (es)
Inventor
Ian Frederick Skidmore
Lawrence Henry Lunts
Harry Finch
Alan Naylor
Ian Baxter Campbell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES2002036A6 publication Critical patent/ES2002036A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/46—Aniline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the formula (I> < IMAGE > wherein X represents a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene and Y represents a bond, C1-4 alkylene, C2-4 alkenylene or C2-4 alkynylene, the sum total of carbon atoms in X and Y being not more than 8 Ar represents a phenyl group substituted by one or more substituents selected from nitro, -(CH2)qR [where R is C1-3 alkoxy, -NR<3>R<4> (where R<3> and R<4> each represent a hydrogen atom, or a C1-4 alkyl group, or-NR<3>R<4> forms a saturated heterocyclic amino group which has 5-7 ring members), -NR<5>COR<6> (where R<5> represents a hydrogen atom or a C1-4alkyl group, and R<6> represents a hydrogen atom or a C1-4alkyl, C1-4alkoxy or-NR<3>R<4> group), and q is 1 to 3], -(CH2)rR<7> [where R<7> represents -NR<5>SO2R<8> (where R<8> represents a C1-4 alkyl, phenyl or -NR<3>R<4> group),- NR<5>COCH2N(R<5>)2 (where each of the groups R<5> represents a hydrogen atom or a C1-4 alkyl group), -COR<9 > (where R<9> represents hydroxy, C1-4 alkoxy or a NR<3>R<4>), -SR<10> (where R<10> is a hydrogen atom, or a C1-4 alkyl group optionally substituted by hydroxy, C1-4 alkoxy or NR<3>R<4>), -SOR<10>, -SO2R10, -CN, or -NR11R<12> (where R<11> and R<12> represent a hydrogen atom or a C1-4 alkyl group, at least one of which is C2-4 alkyl substituted by a hydroxy, C1-4 alkoxy or NR<3>R<4> group), and r is 0 to 3], -O(CH2)qCOR<9>, or -O(CH2)tR<13> [where R<13> represents hydroxy, NR<3>R<4>, NR<11>R<12> or a C1-4alkoxy group optionally substituted by hydroxy, C1-4 alkoxy or NR<3>R<4>,and t is 2 or 3]. R<1> and R<2> each represents a hydrogen atom or a C1-3 alkyl group, the sum total of carbon atoms in R<1> and R<2> being not more than 4 and physiologically acceptable salts and solvates (e.g. hydrates) thereof, have a stimulant action at a beta 2-adreno-receptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.
ES8602594A 1985-10-15 1986-10-14 Dichloroaniline derivatives Expired ES2002036A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858525321A GB8525321D0 (en) 1985-10-15 1985-10-15 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2002036A6 true ES2002036A6 (en) 1988-07-01

Family

ID=10586651

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602594A Expired ES2002036A6 (en) 1985-10-15 1986-10-14 Dichloroaniline derivatives

Country Status (21)

Country Link
JP (1) JPS62149651A (en)
KR (1) KR870003970A (en)
AT (1) AT395972B (en)
AU (1) AU591188B2 (en)
BE (1) BE905601A (en)
CA (1) CA1296335C (en)
CH (1) CH669787A5 (en)
DE (1) DE3634974A1 (en)
DK (1) DK491786A (en)
ES (1) ES2002036A6 (en)
FI (1) FI89164C (en)
FR (1) FR2591590B1 (en)
GB (2) GB8525321D0 (en)
IE (1) IE59466B1 (en)
IL (2) IL78432A (en)
IT (1) IT1205360B (en)
NL (1) NL8602575A (en)
NO (1) NO164895C (en)
PT (1) PT83531B (en)
SE (1) SE467541B (en)
ZA (1) ZA867772B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173685A (en) * 1984-04-17 1985-10-18 Glaxo Group Ltd Safety and pouring stopper
GB8718938D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
US5149698A (en) * 1987-08-11 1992-09-22 Glaxo Group Limited Chloroaniline derivatives
GB8718939D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
AU609209B2 (en) * 1987-11-13 1991-04-26 Glaxo Group Limited Phenethanolamine derivatives
ZA889405B (en) * 1987-12-18 1989-12-27 Glaxo Group Ltd Ethanolamine derivatives
DK702188A (en) * 1987-12-18 1989-06-19 Glaxo Group Ltd ETHANOLAMINE DERIVATIVES
GB8808892D0 (en) * 1988-04-15 1988-05-18 British Bio Technology Gene synthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618005A1 (en) * 1966-09-22 1971-09-09 Thomae Gmbh Dr K Process for the preparation of new amino-dihalogen-phenyl-ethylamines
DE2351281C3 (en) * 1973-10-12 1981-07-30 Dr. Karl Thomae Gmbh, 7950 Biberach Aminophenylethanolamine derivatives, their production and use
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
DK173685A (en) * 1984-04-17 1985-10-18 Glaxo Group Ltd Safety and pouring stopper
GB8426191D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds

Also Published As

Publication number Publication date
IE59466B1 (en) 1994-02-23
AT395972B (en) 1993-04-26
DK491786D0 (en) 1986-10-14
AU591188B2 (en) 1989-11-30
KR870003970A (en) 1987-05-06
BE905601A (en) 1987-04-15
IT8648547A0 (en) 1986-10-14
SE8604349D0 (en) 1986-10-14
ATA273486A (en) 1992-09-15
PT83531B (en) 1989-05-31
PT83531A (en) 1986-11-01
SE467541B (en) 1992-08-03
NL8602575A (en) 1987-05-04
NO864101D0 (en) 1986-10-14
NO164895B (en) 1990-08-20
JPS62149651A (en) 1987-07-03
IE862707L (en) 1987-04-15
CH669787A5 (en) 1989-04-14
FI89164B (en) 1993-05-14
DK491786A (en) 1987-04-16
FI864137A0 (en) 1986-10-14
NO164895C (en) 1990-11-28
FR2591590B1 (en) 1990-05-11
NO864101L (en) 1987-04-21
GB2182658A (en) 1987-05-20
FR2591590A1 (en) 1987-06-19
FI864137A (en) 1987-04-16
SE8604349L (en) 1987-04-16
ZA867772B (en) 1988-07-27
GB2182658B (en) 1990-01-31
DE3634974A1 (en) 1987-05-27
CA1296335C (en) 1992-02-25
IL78432A (en) 1990-09-17
GB8624630D0 (en) 1986-11-19
AU6395986A (en) 1987-04-16
IT1205360B (en) 1989-03-15
FI89164C (en) 1993-08-25
IL80294A (en) 1990-11-29
GB8525321D0 (en) 1985-11-20

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-10-14