MY103817A - Chloroaniline derivatives - Google Patents

Chloroaniline derivatives

Info

Publication number
MY103817A
MY103817A MYPI89000167A MYPI19890167A MY103817A MY 103817 A MY103817 A MY 103817A MY PI89000167 A MYPI89000167 A MY PI89000167A MY PI19890167 A MYPI19890167 A MY PI19890167A MY 103817 A MY103817 A MY 103817A
Authority
MY
Malaysia
Prior art keywords
group
alkyl
atom
alkylene
substituted
Prior art date
Application number
MYPI89000167A
Inventor
Henry Charles Lunts Lawrence
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to MYPI89000167A priority Critical patent/MY103817A/en
Publication of MY103817A publication Critical patent/MY103817A/en

Links

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

THE INVENTION PROVIDES COMPOUNDS OF THE GENERAL FORMULA (1) (FORMULA 1) AND PHYSIOLOGICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF, WHEREIN Q REPRESENTS CHLORINE ATOM OR A TRIFLUOROMETHYL GROUP; X REPRESENTS BOND OR A C2- 6 ALKYLENE, C2- 6 ALKENYLENE OR C2- 6 ALKYNYLENE CHAIN AND Y REPRESENTS A BOND, OR A C1- 6 ALKYLENE, C2- 6 ALKENYLENE OR C2- 6 ALKYNYLENE CHAIN WITH THE PROVISO THAT THE SUM TOTAL OR CORBON ATOMS IN THE CHAINS X AND Y IS NOT MORE THAN 10, AND THE CHAINS XCH2 AND CH2Y MAY EACH BE OPTIONALLY SUBSTITUTED BY ONE OR TWO C1- 3 ALKYL GROUPS, OR, WHEN ONE CARBON ATOM IS SUBSTITUTEDBY TWO ALKYL GROUPS, THESE MAY BE LINKED TO FORM AN ALKYLENE GROUP; R REPRESENTS A HYDROGEN ATOM OR A C1- 3 ALKYL GROUP; R1 AND R2 EACH REPRESENT A HYDROGEN ATOM OR A C1- 3 ALKYL GROUP, WITH THE PROVISO THAT THE SUM TOTAL OF CARBON ATOMS IN R1 AND R2 IS NOT MORE THAN 4; AND HET REPRESENTS BENZOHETEROARYL OR A MONOCYCLIC HETEROARYL GROUP WHEREIN THE HETEROARYL GROUP IS 5 OR 6 MEMBERED AND CONTAINS1, 2, OR 3 HETERO ATOMS ONE OF WHICH IS A NITROGEN ATOM AND THE OTHER (S) IS (ARE) NITROGEN, OXYGEN OR SULPHUR ATOM (S), AND THE GROUP HET MAY OPTIONALLY BE SUBSTITUTED BY ONE OR TWO GROUPS SELECTED FROM C1-4 ALKYL, C1- 4 ALKOXY, HYDROXY, HALOGEN, -NR3 R4 AND - COR8; WHERE R3 AND R4 EACH REPRESENT A HYDROGEN ATOM OR A C1- 4 ALKYL GROUP OR -NR3R4 FORMS A SATURATED HETEROCYCLIC AMINO GROUP WHICH HAS 5- 7 RING MEMBERS AND OPTIONALLY CONTAINS IN THE RING ONE OR MORE ATOMS SELECTED FROM -0- OR -S-OR A GROUP -NH- OR -N (CH3);- AND R8 REPRESENTS HYDROXY, C1- 4 ALKOXY OR - NR3R4 WITH THE PROVISO THAT(i) WHEN HET REPRESENTS A PYRIDYL GROUP SUBSTITUTED BY THE GROUP -NR3R4 OR -COR8 AND Q IS A CHLORINE ATOM, OR (ii) WHEN HET REPRESENTS A PYRIDYL GROUP OPTIONALLY SUBSTITUTED BY ONE OR TWO GROUPS SELECTED FROM HALOGEN, HYDROXY, C1- 3 ALKYL AND C1- 3 ALKOXY, AND Y REPRESENTS A BOND OR A C1- 4 ALKYLENE, C2- 4 ALKENYLENE OR C2- 4 ALKYNYLENE CHAIN, THEN IN BOTH CASES, R REPRESENTS A C1- 3 ALKYL GROUP AND/OR AT LEAST ONE OF THE CHAINS -XCH2- AND -CH2Y- IS SUBSTITUTED BY ONE OR TWO C1- 3 ALKYL GROUPS. THE COMPOUNDS HAVE A STIMULANT ACTION AT 2- ADRENORECEPTORS AND MAY BE USED IN THE TREATMENT OF DISEASES ASSOCIATED WITH REVERSIBLE AIRWAYS OBSTRUCTION SUCH AS ASTHMA AND CHRONIC BRONCHITIS.
MYPI89000167A 1989-02-10 1989-02-10 Chloroaniline derivatives MY103817A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI89000167A MY103817A (en) 1989-02-10 1989-02-10 Chloroaniline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI89000167A MY103817A (en) 1989-02-10 1989-02-10 Chloroaniline derivatives

Publications (1)

Publication Number Publication Date
MY103817A true MY103817A (en) 1993-09-30

Family

ID=79604041

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI89000167A MY103817A (en) 1989-02-10 1989-02-10 Chloroaniline derivatives

Country Status (1)

Country Link
MY (1) MY103817A (en)

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