MD382C2 - Process for obtaining piperazinylalkyl-3(2H) pyridazinone or pharmaceutically acceptable salts thereof - Google Patents
Process for obtaining piperazinylalkyl-3(2H) pyridazinone or pharmaceutically acceptable salts thereofInfo
- Publication number
- MD382C2 MD382C2 MD94-0323A MD940323A MD382C2 MD 382 C2 MD382 C2 MD 382C2 MD 940323 A MD940323 A MD 940323A MD 382 C2 MD382 C2 MD 382C2
- Authority
- MD
- Moldova
- Prior art keywords
- piperazinylalkyl
- pyridazinone
- pharmaceutically acceptable
- alkyl
- obtaining
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- -1 C1-C4 alkyl oxyl Chemical group 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention related to the nitrogenated heterocycling compounds, namely to the process of obtaining new piperazinylalkyl-3(2H) pyridazinone of general formula I:wherein R1 and R2 are similar or different and mean H or C1-C6 alkyl, B- C1-C6 alkylene,Z-unsubstituted or one - or twosubstituted C1-C4 alkyl, C1-C4 alkyl oxyl, trifluoromethyl, halogen or phenyl nitrogroup, or their pharmaceutically acceptable, salts possessing alfa - 1 adrenoformulation affinity, and which may be used in medicine as halogen preparations for high blood pressure and cardial diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT299188 | 1988-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD382C2 true MD382C2 (en) | 1996-06-30 |
Family
ID=3543605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0323A MD382C2 (en) | 1988-12-06 | 1994-10-10 | Process for obtaining piperazinylalkyl-3(2H) pyridazinone or pharmaceutically acceptable salts thereof |
| MD94-0347A MD383C2 (en) | 1988-12-06 | 1994-10-24 | Process for obtaining piperazinylalkyl-3(2H)-pyridazinone or their pharmacentically acceptable salts |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0347A MD383C2 (en) | 1988-12-06 | 1994-10-24 | Process for obtaining piperazinylalkyl-3(2H)-pyridazinone or their pharmacentically acceptable salts |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5034391A (en) |
| EP (1) | EP0372305B1 (en) |
| JP (1) | JPH02200676A (en) |
| KR (1) | KR900009626A (en) |
| CN (1) | CN1022565C (en) |
| AT (1) | ATE92487T1 (en) |
| AU (1) | AU622501B2 (en) |
| CA (1) | CA2004298A1 (en) |
| DD (1) | DD290885A5 (en) |
| DE (1) | DE58905151D1 (en) |
| DK (1) | DK169102B1 (en) |
| ES (1) | ES2058449T3 (en) |
| FI (1) | FI93956C (en) |
| GR (1) | GR3008659T3 (en) |
| HU (1) | HU203748B (en) |
| IE (1) | IE62890B1 (en) |
| IL (1) | IL92442A0 (en) |
| LT (2) | LTIP1615A (en) |
| LV (1) | LV10273B (en) |
| MD (2) | MD382C2 (en) |
| MY (1) | MY106282A (en) |
| NO (1) | NO173441C (en) |
| NZ (1) | NZ231625A (en) |
| PT (1) | PT92488B (en) |
| RU (2) | RU1823874C (en) |
| UA (1) | UA19756A1 (en) |
| YU (1) | YU229289A (en) |
| ZA (1) | ZA899320B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162321A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | 1-naphthyl piperazines useful as 5-HT1A receptor ligands |
| WO1991016314A1 (en) * | 1990-04-25 | 1991-10-31 | Nissan Chemical Industries Ltd. | Pyridazinone derivative |
| HU214320B (en) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Process for the preparation of novel 3 (2H) -pyridazinone derivatives and pharmaceutical compositions containing them |
| IT1254469B (en) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | BENZOPYRANIC AND BENZOTHIOPYRANIC DERIVATIVES |
| US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| IT1258315B (en) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | FLAVONE DERIVATIVES |
| US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| HU225955B1 (en) * | 2001-07-26 | 2008-01-28 | Egis Gyogyszergyar Nyilvanosan | Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| JP2005519895A (en) * | 2002-01-18 | 2005-07-07 | ファルマシア・コーポレーション | Substituted pyridazinones as P38 inhibitors |
| HU227592B1 (en) * | 2002-11-13 | 2011-09-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions |
| US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| DE602005002251D1 (en) * | 2004-02-10 | 2007-10-11 | Janssen Pharmaceutica Nv | PYRIDAZINE HARVES AS ANTAGONISTS OF A4 INTEGRINES |
| EP1720839A1 (en) * | 2004-02-10 | 2006-11-15 | Janssen Pharmaceutica N.V. | Pyridazinones as antagonists of a4 integrins |
| EP2957560B1 (en) * | 2010-02-08 | 2017-08-02 | Allergan, Inc. | Pyridazine derivatives useful as cannabinoid-2 agonists |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1942405A1 (en) * | 1969-08-20 | 1971-09-16 | Byk Gulden Lomberg Chem Fab | Aryl-substituted piperazinylalkylaminouracils or uracila ethers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1086238B (en) * | 1959-02-03 | 1960-08-04 | Basf Ag | Process for the preparation of (4, 5) -dihalopyridazones- (6) |
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| FR2124164A1 (en) * | 1971-02-10 | 1972-09-22 | Ferlux | Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials |
| DE2334009A1 (en) * | 1973-07-04 | 1975-01-23 | Boehringer Mannheim Gmbh | PURIN DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
| FR2261756A1 (en) * | 1974-02-27 | 1975-09-19 | Roussel Uclaf | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
| LU74319A1 (en) * | 1976-02-09 | 1977-08-19 | ||
| JPS5742679A (en) * | 1980-08-29 | 1982-03-10 | Otsuka Pharmaceut Co Ltd | Preparation of phenylpiperazine derivative |
| JPH0641454B2 (en) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | Pyridazinone derivative |
| EP0201765B1 (en) * | 1985-04-27 | 1991-09-18 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| TR22638A (en) * | 1985-07-30 | 1988-01-29 | Nissan Chemical Ind Ltd | PIRIDAZINON TUEREVLER, FOR THE PREPARATION OF THESE AND DAMAGE OELDUERUECUE COMPOUNDS |
| HU195645B (en) * | 1985-10-30 | 1988-06-28 | Gyogyszerkutato Intezet | Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same |
| US4859672A (en) * | 1986-10-29 | 1989-08-22 | Rorer Pharmaceutical Corporation | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone |
| HU198696B (en) * | 1987-01-20 | 1989-11-28 | Nissan Chemical Ind Ltd | Process for producing 3/2h/-pyridazinon derivatives and pharmaceutical compositions containing them as active components |
| GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
-
1989
- 1989-11-21 IE IE372189A patent/IE62890B1/en not_active IP Right Cessation
- 1989-11-23 ES ES89121681T patent/ES2058449T3/en not_active Expired - Lifetime
- 1989-11-23 DE DE8989121681T patent/DE58905151D1/en not_active Expired - Fee Related
- 1989-11-23 AT AT89121681T patent/ATE92487T1/en not_active IP Right Cessation
- 1989-11-23 EP EP89121681A patent/EP0372305B1/en not_active Expired - Lifetime
- 1989-11-24 IL IL92442A patent/IL92442A0/en not_active IP Right Cessation
- 1989-11-29 MY MYPI89001659A patent/MY106282A/en unknown
- 1989-11-30 CA CA002004298A patent/CA2004298A1/en not_active Abandoned
- 1989-11-30 US US07/443,166 patent/US5034391A/en not_active Expired - Fee Related
- 1989-12-04 NZ NZ231625A patent/NZ231625A/en unknown
- 1989-12-04 PT PT92488A patent/PT92488B/en not_active IP Right Cessation
- 1989-12-04 AU AU45898/89A patent/AU622501B2/en not_active Ceased
- 1989-12-04 KR KR1019890017840A patent/KR900009626A/en not_active Ceased
- 1989-12-05 DK DK611789A patent/DK169102B1/en not_active IP Right Cessation
- 1989-12-05 DD DD89335270A patent/DD290885A5/en not_active IP Right Cessation
- 1989-12-05 HU HU896432A patent/HU203748B/en not_active IP Right Cessation
- 1989-12-05 JP JP1314490A patent/JPH02200676A/en active Pending
- 1989-12-05 NO NO894856A patent/NO173441C/en unknown
- 1989-12-05 RU SU894742661A patent/RU1823874C/en active
- 1989-12-05 UA UA4742661A patent/UA19756A1/en unknown
- 1989-12-05 FI FI895824A patent/FI93956C/en not_active IP Right Cessation
- 1989-12-06 CN CN89109090A patent/CN1022565C/en not_active Expired - Fee Related
- 1989-12-06 YU YU02292/89A patent/YU229289A/en unknown
- 1989-12-06 ZA ZA899320A patent/ZA899320B/en unknown
-
1990
- 1990-12-24 RU SU904831923A patent/RU2024517C1/en active
-
1993
- 1993-08-05 GR GR930400672T patent/GR3008659T3/el unknown
- 1993-11-12 LV LVP-93-1218A patent/LV10273B/en unknown
- 1993-12-16 LT LTIP1615A patent/LTIP1615A/en not_active Application Discontinuation
-
1994
- 1994-01-27 LT LTIP1808A patent/LT3945B/en not_active IP Right Cessation
- 1994-10-10 MD MD94-0323A patent/MD382C2/en unknown
- 1994-10-24 MD MD94-0347A patent/MD383C2/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1942405A1 (en) * | 1969-08-20 | 1971-09-16 | Byk Gulden Lomberg Chem Fab | Aryl-substituted piperazinylalkylaminouracils or uracila ethers |
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