MD383C2 - Process for obtaining piperazinylalkyl-3(2H)-pyridazinone or their pharmacentically acceptable salts - Google Patents
Process for obtaining piperazinylalkyl-3(2H)-pyridazinone or their pharmacentically acceptable saltsInfo
- Publication number
- MD383C2 MD383C2 MD94-0347A MD940347A MD383C2 MD 383 C2 MD383 C2 MD 383C2 MD 940347 A MD940347 A MD 940347A MD 383 C2 MD383 C2 MD 383C2
- Authority
- MD
- Moldova
- Prior art keywords
- hydrogen
- alkyl
- piperazinylalkyl
- pyridazinone
- obtaining
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- -1 (C1-C6)-alcoxy Chemical group 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Utilization: as a preparation for high blood pressure. The summary of the invention: the product is of formula:wherein R1 - is hydrogen, phenyl, (C1-C6)-alkyl, unsubstituted or substituted hydroxyl or NR4R5 group, where R4 and R5 may be similar or different and represents hydrogen, methyl, or ethyl, or oxygroup, or phenyl, or hydrogen, R2 or R3 - is hydrogen or halogen, at least one of R2 or R3 - is hydrogen, R6 - hydrogen, B-(C1-C4)-alkyl, R7 or R8 can be similar or different and represent hydrogen and (C1-C6)-alkyl, Z - unsubstituted or substituted singly or multtiply by (C1-C6)-alkyl, (C1-C6)-alcoxy, benzyloxygroup, trifluoromethyl, halogen, phenyl nitrogroup or puridyl. The reagent 1-is a product of formula:wherein R1, R2 and R3 are determined above and M means the splitted off group.The reagent 2:wherein R6, B, R7, R8 are determined above.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT299188 | 1988-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD383C2 true MD383C2 (en) | 1996-06-30 |
Family
ID=3543605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0323A MD382C2 (en) | 1988-12-06 | 1994-10-10 | Process for obtaining piperazinylalkyl-3(2H) pyridazinone or pharmaceutically acceptable salts thereof |
| MD94-0347A MD383C2 (en) | 1988-12-06 | 1994-10-24 | Process for obtaining piperazinylalkyl-3(2H)-pyridazinone or their pharmacentically acceptable salts |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0323A MD382C2 (en) | 1988-12-06 | 1994-10-10 | Process for obtaining piperazinylalkyl-3(2H) pyridazinone or pharmaceutically acceptable salts thereof |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5034391A (en) |
| EP (1) | EP0372305B1 (en) |
| JP (1) | JPH02200676A (en) |
| KR (1) | KR900009626A (en) |
| CN (1) | CN1022565C (en) |
| AT (1) | ATE92487T1 (en) |
| AU (1) | AU622501B2 (en) |
| CA (1) | CA2004298A1 (en) |
| DD (1) | DD290885A5 (en) |
| DE (1) | DE58905151D1 (en) |
| DK (1) | DK169102B1 (en) |
| ES (1) | ES2058449T3 (en) |
| FI (1) | FI93956C (en) |
| GR (1) | GR3008659T3 (en) |
| HU (1) | HU203748B (en) |
| IE (1) | IE62890B1 (en) |
| IL (1) | IL92442A0 (en) |
| LT (2) | LTIP1615A (en) |
| LV (1) | LV10273B (en) |
| MD (2) | MD382C2 (en) |
| MY (1) | MY106282A (en) |
| NO (1) | NO173441C (en) |
| NZ (1) | NZ231625A (en) |
| PT (1) | PT92488B (en) |
| RU (2) | RU1823874C (en) |
| UA (1) | UA19756A1 (en) |
| YU (1) | YU229289A (en) |
| ZA (1) | ZA899320B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162321A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | 1-naphthyl piperazines useful as 5-HT1A receptor ligands |
| DK0482208T3 (en) * | 1990-04-25 | 2000-09-18 | Nissan Chemical Ind Ltd | Pyridazinone derivatives |
| HU214320B (en) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Process for the preparation of novel 3 (2H) -pyridazinone derivatives and pharmaceutical compositions containing them |
| US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| IT1254469B (en) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | BENZOPYRANIC AND BENZOTHIOPYRANIC DERIVATIVES |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| IT1258315B (en) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | FLAVONE DERIVATIVES |
| US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| HU225955B1 (en) * | 2001-07-26 | 2008-01-28 | Egis Gyogyszergyar Nyilvanosan | Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| AU2003209321A1 (en) * | 2002-01-18 | 2003-07-30 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| HU227592B1 (en) * | 2002-11-13 | 2011-09-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions |
| US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| KR20070004676A (en) * | 2004-02-10 | 2007-01-09 | 얀센 파마슈티카 엔.브이. | Pyridazinone as an Antagonist of Alpha-4 Integrin |
| KR20070001976A (en) * | 2004-02-10 | 2007-01-04 | 얀센 파마슈티카 엔.브이. | Pyridazinone urea as an antagonist of alpha-4 integrin |
| JP2013518907A (en) * | 2010-02-08 | 2013-05-23 | アラーガン インコーポレイテッド | Pyridazine derivatives useful as cannabinoid-2 agonists |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1942405A1 (en) * | 1969-08-20 | 1971-09-16 | Byk Gulden Lomberg Chem Fab | Aryl-substituted piperazinylalkylaminouracils or uracila ethers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1086238B (en) * | 1959-02-03 | 1960-08-04 | Basf Ag | Process for the preparation of (4, 5) -dihalopyridazones- (6) |
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| FR2124164A1 (en) * | 1971-02-10 | 1972-09-22 | Ferlux | Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials |
| DE2334009A1 (en) * | 1973-07-04 | 1975-01-23 | Boehringer Mannheim Gmbh | PURIN DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
| FR2261756A1 (en) * | 1974-02-27 | 1975-09-19 | Roussel Uclaf | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
| LU74319A1 (en) * | 1976-02-09 | 1977-08-19 | ||
| JPS5742679A (en) * | 1980-08-29 | 1982-03-10 | Otsuka Pharmaceut Co Ltd | Preparation of phenylpiperazine derivative |
| JPH0641454B2 (en) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | Pyridazinone derivative |
| EP0201765B1 (en) * | 1985-04-27 | 1991-09-18 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| YU134686A (en) * | 1985-07-30 | 1988-02-29 | Nissan Chemical Ind Ltd | Process for preparing new derivatives 3-(2h)-pyridazinone |
| HU195645B (en) * | 1985-10-30 | 1988-06-28 | Gyogyszerkutato Intezet | Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same |
| US4859672A (en) * | 1986-10-29 | 1989-08-22 | Rorer Pharmaceutical Corporation | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone |
| HU198696B (en) * | 1987-01-20 | 1989-11-28 | Nissan Chemical Ind Ltd | Process for producing 3/2h/-pyridazinon derivatives and pharmaceutical compositions containing them as active components |
| GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
-
1989
- 1989-11-21 IE IE372189A patent/IE62890B1/en not_active IP Right Cessation
- 1989-11-23 EP EP89121681A patent/EP0372305B1/en not_active Expired - Lifetime
- 1989-11-23 ES ES89121681T patent/ES2058449T3/en not_active Expired - Lifetime
- 1989-11-23 DE DE8989121681T patent/DE58905151D1/en not_active Expired - Fee Related
- 1989-11-23 AT AT89121681T patent/ATE92487T1/en not_active IP Right Cessation
- 1989-11-24 IL IL92442A patent/IL92442A0/en not_active IP Right Cessation
- 1989-11-29 MY MYPI89001659A patent/MY106282A/en unknown
- 1989-11-30 US US07/443,166 patent/US5034391A/en not_active Expired - Fee Related
- 1989-11-30 CA CA002004298A patent/CA2004298A1/en not_active Abandoned
- 1989-12-04 NZ NZ231625A patent/NZ231625A/en unknown
- 1989-12-04 PT PT92488A patent/PT92488B/en not_active IP Right Cessation
- 1989-12-04 AU AU45898/89A patent/AU622501B2/en not_active Ceased
- 1989-12-04 KR KR1019890017840A patent/KR900009626A/en not_active Ceased
- 1989-12-05 FI FI895824A patent/FI93956C/en not_active IP Right Cessation
- 1989-12-05 DD DD89335270A patent/DD290885A5/en not_active IP Right Cessation
- 1989-12-05 DK DK611789A patent/DK169102B1/en not_active IP Right Cessation
- 1989-12-05 NO NO894856A patent/NO173441C/en unknown
- 1989-12-05 UA UA4742661A patent/UA19756A1/en unknown
- 1989-12-05 JP JP1314490A patent/JPH02200676A/en active Pending
- 1989-12-05 HU HU896432A patent/HU203748B/en not_active IP Right Cessation
- 1989-12-05 RU SU894742661A patent/RU1823874C/en active
- 1989-12-06 YU YU02292/89A patent/YU229289A/en unknown
- 1989-12-06 ZA ZA899320A patent/ZA899320B/en unknown
- 1989-12-06 CN CN89109090A patent/CN1022565C/en not_active Expired - Fee Related
-
1990
- 1990-12-24 RU SU904831923A patent/RU2024517C1/en active
-
1993
- 1993-08-05 GR GR930400672T patent/GR3008659T3/el unknown
- 1993-11-12 LV LVP-93-1218A patent/LV10273B/en unknown
- 1993-12-16 LT LTIP1615A patent/LTIP1615A/en not_active Application Discontinuation
-
1994
- 1994-01-27 LT LTIP1808A patent/LT3945B/en not_active IP Right Cessation
- 1994-10-10 MD MD94-0323A patent/MD382C2/en unknown
- 1994-10-24 MD MD94-0347A patent/MD383C2/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1942405A1 (en) * | 1969-08-20 | 1971-09-16 | Byk Gulden Lomberg Chem Fab | Aryl-substituted piperazinylalkylaminouracils or uracila ethers |
Non-Patent Citations (1)
| Title |
|---|
| Вейганд-Хильгетаг. Методы, эксперименты в органической химии, М.. Химия, 1968, с.413 * |
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